The Diagnostic and Prognostic Value of Plasmatic Exosome Count in Cancer Patients and in Patients with Other Pathologies

Fais, Stefano; Logozzi, Mariantonia

doi:10.3390/ijms25021049

Cited by 1 publication

(1 citation statement)

References 71 publications

(87 reference statements)

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“…Research to date has shown that EVs in circulation in tumor patients are useful and offer practical advantages, because they are stable and accessible via minimally invasive procedures, allowing a regular follow-up over time to monitor tumor progression and therapeutic results [ 16 ]. EVs obtained from the liquid biopsy of tumor patients with no previous cancer history constitute a promising tool for early cancer diagnosis and for evaluating cancer progression [ 12 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types

Alberti,

Sánchez-López,

Marcilla

et al. 2024

IJMS

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Glioblastoma multiforme (GBM) is a malignancy of bad prognosis, and advances in early detection and treatment are needed. GBM is heterogenous, with varieties differing in malignancy within a tumor of a patient and between patients. Means are needed to distinguish these GMB forms, so that specific strategies can be deployed for patient management. We study the participation of the chaperone system (CS) in carcinogenesis. The CS is dynamic, with its members moving around the body in extracellular vesicles (EVs) and interacting with components of other physiological systems in health and disease, including GBM. Here, we describe the finding of high amounts of Hsp70 (HSPA1A) and the calcitonin receptor protein (CTR) in EVs in patients with GBM. We present a standardized protocol for collecting, purifying, and characterizing EVs carrying Hsp70 and CTR in plasma-derived EVs from patients with GBM. EVs from GBM patients were obtained just before tumor ablative surgery (T0) and 7 days afterwards (T1); Hsp70 was highly elevated at T0 and less so at T1, and CTR was greatly increased at T0 and reduced to below normal values at T1. Our results encourage further research to assess Hsp70 and CTR as biomarkers for differentiating tumor forms and to determine their roles in GBM carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types

Alberti,

Sánchez-López,

Marcilla

et al. 2024

IJMS

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The Diagnostic and Prognostic Value of Plasmatic Exosome Count in Cancer Patients and in Patients with Other Pathologies

Abstract: The extent of both scientific articles and reviews on extracellular vesicles (EVs) has grown impressively over the last few decades [...]

Cited by 1 publication

References 71 publications

Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types

Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types

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