The diagnostic accuracy of high b-value diffusion- and T2-weighted imaging for the detection of prostate cancer: a meta-analysis

Syer, Tom; Godley, Keith; Cameron, Donnie; Malcolm, Paul

doi:10.1007/s00261-017-1400-4

Cited by 9 publications

(7 citation statements)

References 59 publications

(75 reference statements)

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“…Diagnostic possibilities would be increased after fused T2WI and DWI for lung cancers and BPNMs. T2WI combined with DWI may be a valuable tool for detecting prostate cancer in the overall evaluation of prostate cancer [ 33 , 34 ], and myometrial invasion and staging of endometrial carcinoma [ 35 , 36 ]. Adding DWI to T2WI is helpful for detecting viable tumors after neoadjuvant chemoradiation therapy compared with T2WI alone or PET/CT in patients with locally advanced rectal cancer [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses

Usuda

Ishikawa

Iwai

et al. 2021

Cancers

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The purpose of this study is to determine whether the combination assessment of DWI and T2-weighted imaging (T2WI) improves the diagnostic ability for differential diagnosis of lung cancer from benign pulmonary nodules and masses (BPNMs). The optimal cut-off value (OCV) for differential diagnosis was set at 1.470 × 10−3 mm2/s for apparent diffusion coefficient (ADC), and at 2.45 for T2 contrast ratio (T2 CR). The ADC (1.24 ± 0.29 × 10−3 mm2/s) of lung cancer was significantly lower than that (1.69 ± 0.58 × 10−3 mm2/s) of BPNM. The T2 CR (2.01 ± 0.52) of lung cancer was significantly lower than that (2.74 ± 1.02) of BPNM. As using the OCV for ADC, the sensitivity was 83.9% (220/262), the specificity 63.4% (33/52), and the accuracy 80.6% (253/314). As using the OCV for T2 CR, the sensitivity was 89.7% (235/262), the specificity 61.5% (32/52), and the accuracy 85.0% (267/314). In 212 PNMs which were judged to be malignant by both DWI and T2WI, 203 PNMs (95.8%) were lung cancers. In 33 PNMs which were judged to be benign by both DWI and T2WI, 23 PNMs (69.7%) were BPNMs. The combined assessment of DWI and T2WI could judge PNMs more precisely and would be acceptable for differential diagnosis of PNMs.

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Section: Discussionmentioning

confidence: 99%

Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses

Usuda

Ishikawa

Iwai

et al. 2021

Cancers

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“…In the literature, there have been several articles concerning the diagnostic performance of T2WI and DWI for differential diagnosis for many other organs of the body. T2WI combined with DWI may be a useful tool for detecting prostate cancer in the overall evaluation of prostate cancer [34,35], and myometrial invasion and staging of endometrial carcinoma [36,37]. Diagnostic possibilities would be increased after T2WI and DWI are fused for the diagnosing of lung cancer and BPNMs [38].…”

Section: Discussionmentioning

confidence: 99%

Novel Insights of T2-Weighted Imaging: Significance for Discriminating Lung Cancer from Benign Pulmonary Nodules and Masses

Usuda

Iwai

Yamagata

et al. 2021

Cancers

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Diffusion-weighted imaging is useful for discriminating lung cancer from benign pulmonary nodules and masses (BPNMs), however the diagnostic capability is not perfect. The aim of this research was to clarify whether T2-weighted imaging (T2WI) is efficient in discriminating lung cancer from BPNMs, especially from pulmonary abscesses. A T2 contrast ratio (T2 CR) for a pulmonary nodule is defined as the ratio of T2 signal intensity of a pulmonary nodule divided by the T2 signal intensity of the rhomboid muscle. There were 52 lung cancers and 40 inflammatory BPNMs (mycobacteria disease 12, pneumonia 13, pulmonary abscess 9, other 6) and seven non-inflammatory BPNMs. The T2 CR (2.14 ± 0.63) of lung cancers was significantly lower than that (2.68 ± 1.04) of BPNMs (p = 0.0021). The T2 CR of lung cancers was significantly lower than that (2.93 ± 0.26) of pulmonary abscesses (p = 0.011). When the optical cutoff value of T2 CR was set as 2.44, the sensitivity was 0.827 (43/52), the specificity 0.596 (28/47), the accuracy 0.717 (71/99), the positive predictive value 0.694 (43/62), and the negative predictive value 0.757 (28/37). T2 CR of T2WI is useful in discriminating lung cancer from BPNMs. Pulmonary abscesses, which show strong restricted diffusion in DWI, can be differentiated from lung cancers using T2WI.

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“…Current studies have shown that ADC maps illustrate the histopathological features of the lesion. [ 16 , 17 ] ADC values were significantly lower in the PCa group than that in prostatitis, and ADC value alone showed high sensitivity in detecting PCa. [ 18 ] However, the specificity of MRI for PCa is limited, and MRI likely missed some prostatic and extraprostatic lesions.…”

Section: Discussionmentioning

confidence: 99%

68Ga-PSMA-11 PET/CT combining ADC value of MRI in the diagnosis of naive prostate cancer

Wang¹,

Yu²,

Zang³

et al. 2020

Medicine

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68 Ga-PSMA-11 positron emission computed tomography /computed tomography (PET/CT) is more sensitive than magnetic resonance imaging (MRI) in detecting prostate cancer (PCa). We evaluated the value of 68 Ga-PSMA-11 PET/CT with MRI in treatment-naive PCa. This retrospective study was approved by the hospital ethics committee. The MRI and 68 Ga-PSMA-11 PET/CT imaging data of 63 cases of highly suspected PCa were enrolled in this study. The SUV max and apparent diffusion coefficient (ADC), and their ratio, were assessed as diagnostic markers to distinguish PCa from benign disease. There were 107 prostate lesions detected in 63 cases. Forty cases with 64 malignant primary lesions were confirmed PCa, whereas 23 cases had 43 benign lesions. PSMA-avid lesions correlated with hypointense signal on ADC maps and hyperintense signal on diffusion-weighted imaging. The ADC of PCa was lower than that of benign lesions, and SUV max and SUV max /ADC of PCa was higher than that of benign lesions ( P < .01). ADC had significant negative correlation with Gleason score (GS) and SUV max , SUV max , and SUV max /ADC positively correlated with GS. From ROC analysis, we established cutoff values of ADC, SUV max , and SUV max /ADC at 1.02 × 10 −3 mm 2 /s, 11.72, and 12.35, respectively, to differentiate PCa from benign lesions. The sensitivity, specificity, and AUC were 90.6%, 58.1%, and 0.816 for ADC, 67.2%, 97.7%, and 0.905 for SUV max , and 81.2%, 88.4%, and 0.929 for SUV max /ADC, respectively. 68 Ga-PSMA-11 PET/CT combined with MRI offers higher diagnostic efficacy in the detection of PCa than either modality alone.

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The diagnostic accuracy of high b-value diffusion- and T2-weighted imaging for the detection of prostate cancer: a meta-analysis

Cited by 9 publications

References 59 publications

Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses

Combination Assessment of Diffusion-Weighted Imaging and T2-Weighted Imaging Is Acceptable for the Differential Diagnosis of Lung Cancer from Benign Pulmonary Nodules and Masses

Novel Insights of T2-Weighted Imaging: Significance for Discriminating Lung Cancer from Benign Pulmonary Nodules and Masses

68Ga-PSMA-11 PET/CT combining ADC value of MRI in the diagnosis of naive prostate cancer

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