The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease

Henderson, Paul; Casey, Aoife; Lawrence, Sally; Kennedy, Nicholas A; Kingstone, Kathleen; Rogers, Pam; Gillett, Peter M.; Wilson, David C.

doi:10.1038/ajg.2012.33

Cited by 101 publications

(90 citation statements)

References 31 publications

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“…In adults, the ratio of CD to UC is 2 : 3, 29 whereas in children the ratio is much higher, at 2.3 : 1. 30 There are other forms of colitis, such as collagenous colitis and lymphocytic colitis, sometimes combined as 'microscopic colitis', which can cause persistent non-bloody diarrhoea, but these are usually seen in older people. The mean age at diagnosis in a Swedish study 31 was 64 years for collagenous and 59 years for lymphocytic.…”

Section: Secondary Carementioning

confidence: 99%

“…Henderson et al 30 report results from a relatively large group of children, by linking referrals to the regional paediatric gastroenterology service (5600) with laboratory calprotectin results (4155 results) and endoscopy records, to create a cohort of 190 children investigated for possible IBD, who all had calprotectin and full endoscopy records. Ninety-one were shown to have IBD, of whom 62 had CD, 21 UC and the other eight unclassified IBD.…”

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confidence: 99%

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Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

235

201

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Section: Secondary Carementioning

confidence: 99%

mentioning

confidence: 99%

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

235

201

View full text Add to dashboard Cite

“…Table 2 shows select studies utilizing FC analysis in pediatric populations with suspected or soon after diagnosis of IBD. [36][37][38][39] Table 3 lists pediatric studies in which FC was analyzed in patients with a long-standing diagnosis of IBD. [40][41][42][43][44][45] Most of these research groups adopted the manufacturer's recommended cut-offs for normal FC, between 50 and 100 µg/g.…”

Section: A Marker Of Inflammatory Bowel Diseasementioning

confidence: 99%

Calprotectin: Clinical Applications in Pediatrics

Herrera

Christensen

Helms

2016

The Journal of Pediatric Pharmacology and Therapeutics

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As seen over the past 20 years, calprotectin has evolved as a novel, non-invasive biomarker of gastrointestinal (GI) inflammation. We present this review of calprotectin in pediatrics. This article will focus on studies using calprotectin concentrations from different body fluids to monitor inflammation in different disease states and conditions. The ultimate goal of our group is to lay down a foundation as we consider using calprotectin prospectively as a marker of intestinal inflammation that could lead to further testing and possibly a marker of preparedness for feeding. We surveyed all published studies in English of calprotectin in neonates, infants, children, and adolescents through February 2014. We will discuss calprotectin's basic properties and analysis such as characteristics, identification, presence in body fluids, and maturational development. In addition, calprotectin's use in inflammatory diseases exploring both GI and non-GI conditions will be evaluated and compared with other serum markers presently available. Finally, a summary of our findings and discussion of future work that could be undertaken in order to render calprotectin as a more useful monitoring tool to the medical research community will complete the review.

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“…Calprotectin is a neutrophil-derived protein excreted in stool in abundance in the presence of mucosal inflammation [17][18][19][20]. Fecal calprotectin (FC) outperforms serum markers in the detection of bowel wall inflammation and reflects the endoscopic activity of CD reliably in both children and adults [17,18,[20][21][22][23].…”

mentioning

confidence: 99%

“…Fecal calprotectin (FC) outperforms serum markers in the detection of bowel wall inflammation and reflects the endoscopic activity of CD reliably in both children and adults [17,18,[20][21][22][23]. Its concentration has been shown to increase in the presence of histological pouch inflammation following proctocolectomy for ulcerative colitis [24].…”

mentioning

confidence: 99%

Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents

Hukkinen

Pakarinen

Merras‐Salmio

et al. 2016

Journal of Pediatric Surgery

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a b s t r a c t a r t i c l e i n f oBackground: Fecal calprotectin (FC) correlates with endoscopic recurrence of Crohn's disease (CD) in adults but has not been studied among children postoperatively. We aimed to analyze whether FC relates with postoperative CD recurrence in children. Methods: Altogether 51 postoperative endoscopies and FC measurements from 22 patients having undergone surgery for CD at age ≤18 years were included. Results: Ileocecal resection (n = 15), small bowel resection (n = 6), or left hemicolectomy (n = 1) was performed at median age of 15.1 (interquartile range 14.4-17.6) years. Following surgery, FC decreased significantly (659 vs. 103 μg/g, p = 0.001). During median follow-up of 5.7 (4.2-7.7) years, either endoscopic or histological recurrence occurred in 17 patients (77%). FC N139 μg/g at time of endoscopy or FC increase of 79 μg/g compared to first postoperative value was suggestive of endoscopic recurrence (Rutgeerts score i2-i4), while FC N101 μg/g or increase of 21 μg/g indicated histological recurrence. Best accuracy for prediction of recurrence was obtained by combining FC at endoscopy and the postoperative increase of FC. The corresponding AUROC values were 0.74 (95% 0.58-0.89) for endoscopic recurrence whereas 0.81 (95% CI 0.67-0.95) for histological recurrence. Conclusion: FC is a useful surrogate marker of postoperative recurrence also in pediatric CD patients.

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The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease

Abstract: This study demonstrates that FC is an invaluable tool in determining those children who may require endoscopy for suspected IBD, and elevated values should prompt further investigation.

Cited by 101 publications

References 31 publications

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Calprotectin: Clinical Applications in Pediatrics

Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents

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