The diagnosis of primary thyroid lymphoma by fine‐needle aspiration, cell block, and immunohistochemistry technique

Huang, Conggai; Li, Meng-Ze; Wang, Shaohua; Zhou, Tiejun; Haybaeck, Johannes; Yang, Zhihui

doi:10.1002/dc.24526

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…The subtype and the disease stage determine the diagnosis specificity and the prognosis. Despite the identification of DLBCL tends to be relatively easy on cytology, the diagnosis sensitivity of thyroid lymphoma in general, after fine needle aspiration, is increased by the combination of cytology, cell block analysis, and immunohistochemistry [ 16 ]. The tendency for the disease to occur more frequently in patients with long-standing autoimmune diseases including, those of the thyroid, particularly is remarkable [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Thyroid Diseases Mimicking or Concealing Primitive Thyroid Neoplasms: A Call for a “Check and Double-Check” Clinical Mindset

Duhamel,

Balti,

Waelput

et al. 2024

Cureus

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Clinical endocrinologists encounter in their practice patients with thyroid diseases on a daily basis. Still, diagnosis of rare structural thyroid disorders can be quite challenging. In some instances, they do not only impersonate but can also conceal, other conditions such as thyroid carcinomas. We describe a series of patients with structural thyroid disorders including 1) anaplastic thyroid carcinoma initially presenting with features of thyroid abscess; 2) unicentric hyaline vascular Castleman's disease of the thyroid embedded in a stroma of papillary thyroid carcinoma; and 3) primary thyroid lymphoma with a rapid and fulminant evolution. The common challenge in the diagnosis of these cases lies in both their low incidence and their complex presentation. We use the presentation of these cases to raise the attention related to their identification. We highlight the need for precision diagnosis to enable a patient-tailored management approach and improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Rare Thyroid Diseases Mimicking or Concealing Primitive Thyroid Neoplasms: A Call for a “Check and Double-Check” Clinical Mindset

Duhamel,

Balti,

Waelput

et al. 2024

Cureus

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“…In contrast to surgery, they are less invasive ( 8 , 17 , 18 ). The initial diagnostic method for thyroid lymphoma should consist of FNAB with the use of additional techniques, such as the cell block technique, CNB, flow cytometry, and IHC staining for improved diagnostic accuracy ( 19 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

Aggressive primary thyroid lymphoma invading the internal jugular vein: a case series

Su¹,

Han²,

Ma³

2023

Quant Imaging Med Surg

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“…The lack of marked atypia in PTL makes a definitive cytological diagnosis difficult [10]. In contrast to other cases, FNA gave sufficient information to determine the tumor type, even without initial immunohistochemical staining [11]. However, histological verification was also performed to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Intrathyroidal Non-Hodgkin Lymphoma: A Case Report

Hristozov,

Dimitrova,

Shishkov

et al. 2023

Cureus

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Primary thyroid lymphoma (PTL) is a rare disease characterized by the appearance of a rapidly growing solid mass in the cervical region. A major risk factor is chronic autoimmune thyroiditis with lymphocytes infiltrating the thyroid gland. The lymphoproliferative disease is seen more frequently in the females. PTL usually develops in the sixth and seventh decades of life. We present a case of a 66-year-old woman with diffuse primary B-cell thyroid lymphoma with no prior evidence of underlying autoimmune thyroid pathology. The initial localization of the lymphoproliferative disease was in the thyroid gland, but the involvement of regional cervical lymph nodes was also found at the time of diagnosis. After histological verification with immunohistochemistry and staging by imaging, chemotherapy was initiated according to the R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin hydrochloride, Oncovin ® (vincristine), prednisone) protocol. An excellent therapeutic response was achieved with lymphoma remission after six cycles under the mentioned protocol. Thyroid autoantibodies became positive 18 months after rituximab treatment, possibly reflecting the transient suppressive effects of the immunotherapy. The patient was subsequently kept followed up by a multidisciplinary team in the light of possible lymphoma recurrence and/or development of thyroid dysfunction. This case report demonstrates possible challenges for the diagnosis, treatment, and follow-up of this rare thyroid lesion. At the time of diagnosis, the clinical presentation of the disease, the ultrasound image, and the cytological result may be similar to other lowgrade thyroid carcinomas or secondary metastatic involvement of the gland. The initial lack of underlying thyroid autoimmunity makes this distinction even more challenging. Furthermore, despite the rapid resolution, regular long-term monitoring for recurrence is required.

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The diagnosis of primary thyroid lymphoma by fine‐needle aspiration, cell block, and immunohistochemistry technique

Cited by 7 publications

References 46 publications

Rare Thyroid Diseases Mimicking or Concealing Primitive Thyroid Neoplasms: A Call for a “Check and Double-Check” Clinical Mindset

Rare Thyroid Diseases Mimicking or Concealing Primitive Thyroid Neoplasms: A Call for a “Check and Double-Check” Clinical Mindset

Aggressive primary thyroid lymphoma invading the internal jugular vein: a case series

Primary Intrathyroidal Non-Hodgkin Lymphoma: A Case Report

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