The Diagnosis of Preleukaemia

Geary, C. G.

doi:10.1111/j.1365-2141.1983.tb01218.x

Cited by 22 publications

(9 citation statements)

References 12 publications

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“…Indeed, the qualitative and quantitative abnormali ties of the three haematological cell lines fit with the features previously described in MDS [8][9][10]. These included pancytopenia with dyserythropoiesis, gran ulocyte abnormalities like hypogranulation and hypo-and hypersegmentation and megakaryocytic hypoplasia with rare giant platelets in the peripheral blood smear.…”

Section: Discussionmentioning

confidence: 50%

Elliptocytosis and Schistocytosis in Myelodysplasia: Report of Two Cases

Rummens¹,

Verfaillie²,

Criel³

et al. 1986

Acta Haematol

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Marked elliptocytosis and schistocytosis are described as unusual manifestations of haematopoietic dysplasia in two patients. The first patient, whose history was negative for inherited haemolytic anaemias, presented these prominent features on his first admission; 22 months later he developed an acute myeloblastic leukaemia. In the second patient, followed since 4 years for an autoimmune thrombocytopenic purpura, elliptocytosis and schistocytosis appeared 17 months before a pancytopenia established. The patient is now on follow-up and is treated for a refractory anaemia. In both cases bone marrow examinations revealed the typical criteria for myelodysplasia and this diagnosis was confirmed by cytogenetic analysis.

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Section: Discussionmentioning

confidence: 50%

Elliptocytosis and Schistocytosis in Myelodysplasia: Report of Two Cases

Rummens¹,

Verfaillie²,

Criel³

et al. 1986

Acta Haematol

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“…In neither case were the myeloid cell lineages involved, when first studied, an observation that is consistent with cases presented in other comprehensive reviews [ 1-61. Internuclear bridging of erythroblasts is a nonspecific sign of dyserythropoiesis and was, to the best of our knowledge, first described in a case of pernicious anemia and in a case of "anemia of infancy" 1181. It is considered a very rare morphologic phenomenon in the preleukemic state [19][20][21]. Our observations, in addition, suggest that internuclear bridging may be seen only in the early phase of evolution of the preleukemic state.…”

Section: Discussionmentioning

confidence: 55%

Nuclear bridging of erythroblasts in acquired dyserythropoiesis: An early and transient preleukemic marker

Bethlenfalvay

Phaure²,

Phyliky

et al. 1986

American J Hematol

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The clinical, hematologic, and histological characteristics of two patients who progressed from refractory anemia to acute leukemia are described. When first studied, nuclear bridging of erythroblasts, similar to that seen in congenital dyserythropoietic anemia type I and megakaryocytic dysplasia, were the only abnormalities. Within 6 years, both patients died, the first of acute nonlymphocytic leukemia, the second of erythroleukemia. Nuclear bridging of erythroblasts in the marrow of these patients was an early and transient phenomenon and was not observed during the terminal phase of leukemia.

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“…The term smoldering (oligoblastic) acute leukemia was introduced several years ago [18] to distinguish a subleukemic panmyelopathy whose characteristics are: (a) hypercellular bone marrow showing maturation arrest and some other features of ANLL, although with an accumulation of marrow blast cells lower than that ob served in conventional acute leukemias; (b) in most cases the bone marrow ineffec tive dyshemopoiesis leads to a pancytopenic blood picture without leukemic ex pression or with a minimal number of pe ripheral blast cells, and (c) this condition usually occurs in elderly people (preferen t i a l males) with an indolent course [7,8,10,14,23].…”

Section: Discussionmentioning

confidence: 99%

“…Most of these conditions, previously considered as preleukemic states [7,8,13,14,19], are now classified as myelodys plastic syndromes (MDS), mainly as re fractory anemias with an excess of blasts (RAEB), and some of them apparently evolving or in transformation into acute nonlymphocytic leukemia (ANLL) [2,6,8], Finally, other cases may represent, since the beginning, a subset of indolent and subleukemic ANLL.…”

Section: Introductionmentioning

confidence: 99%

Biological Significance of Nonlymphocytic Oligoblastic Leukemia

Sánchez-Fayos¹,

Outeiriño²,

Calabuig³

et al. 1984

Acta Haematol

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Kinetic studies of marrow dividing granulocytic precursors (mitotic index and flash labeling index with ³H-TDR) were carried out in 11 patients with oligoblastic leukemia (OBL). The results were compared with similar data from cases of conventional acute non-lymphocytic leukemia (ANLL). The cytokinetic results were as follows: MI (%) in OBL, mean = 0.75; MI (%) in ANLL, mean = 0.66; p > 0.7; LI (%) in OBL, mean= 15.0; LI (%) in ANLL, mean= 15.4, p > 0.7. The lack of cytokinetic differences between these two groups of patients stands in favor of the hypothesis that OBL might represent a special type of smoldering leukemia with a ‘plateau’ of blast cell accumulation established at a subleukemic level.

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The Diagnosis of Preleukaemia

Cited by 22 publications

References 12 publications

Elliptocytosis and Schistocytosis in Myelodysplasia: Report of Two Cases

Elliptocytosis and Schistocytosis in Myelodysplasia: Report of Two Cases

Nuclear bridging of erythroblasts in acquired dyserythropoiesis: An early and transient preleukemic marker

Biological Significance of Nonlymphocytic Oligoblastic Leukemia

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