The diagnosis of multiple sclerosis

Compston, A; Confavreux, C; Lassmann, H.; McDonald, Ian; Miller, Donald H.; Noseworthy, John H.; Smith, Kenneth J.; Wekerle, H; Miller, DH

doi:10.1016/b978-0-443-07271-0.50009-4

Cited by 19 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 Small venules in the center of lesions are visualized using T2*-weighted MRI because of the paramagnetic effect of deoxyhemoglobin. Here we show that using 7 T T2*-weighted MRI we can reliably distinguish all patients with clinically definite MS (Ͼ40% lesions appeared perivenous) from those without clinical MS (Ͻ40% lesions appeared perivenous).…”

Section: Resultsmentioning

confidence: 99%

“…10 Retrospective evaluation has suggested Fazekas criteria to be highly specific (96%) and moderately sensitive (81%) to the presence of MS. 12 However, these features are not pathognomonic and some patients with cerebral ischemia meet all Fazekas criteria. 13 Small venules in the center of lesions are visualized using T2*-weighted MRI because of the paramagnetic effect of deoxyhemoglobin. Here we show that using 7 T T2*-weighted MRI we can reliably distinguish all patients with clinically definite MS (Ͼ40% lesions appeared perivenous) from those without clinical MS (Ͻ40% lesions appeared perivenous).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions

Tallantyre

Dixon²,

Donaldson³

et al. 2011

Neurology

189

246

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions

Tallantyre

Dixon²,

Donaldson³

et al. 2011

Neurology

189

246

View full text Add to dashboard Cite

show abstract

“…3 In about 90% of patients, the natural progression of MS follows sequential stages, namely subclinical disease, clinical isolated syndrome, relapsing-remitting and progressive forms. 4 Inflammation plays an important pathogenic role, especially in the early stages, thus being the main target for currently available treatments. 5,6 Disease-modifying therapies improve short-term outcomes, but their long-term effects are not yet established.…”

Section: Introductionmentioning

confidence: 99%

“…Diagnostic delay could reduce the available therapeutic options and the opportunity for early intervention, 3,11 which may result in irreversible sequelae. 4 Moreover, as MS global costs increase with disease severity, 12 an early diagnosis could also mitigate the economic burden of MS. Consequently, monitoring the time to diagnosis and understanding causes for delays is an important feature when managing MS patients.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Delay of Multiple Sclerosis in a Portuguese Population

et al. 2019

View full text Add to dashboard Cite

Introduction: Multiple sclerosis is a chronic inflammatory disease, in which a diagnostic delay could reduce the available therapeutic options. Therefore, it is important to monitor the time to diagnosis and understand factors that may potentially reduce it. The objective of this study was to determine the time between the first symptoms and the diagnosis of multiple sclerosis and which factors may contribute to a diagnostic delay.Material and Methods: Cross-sectional multicenter study, with retrospective data analysis, conducted in five tertiary Portuguese hospitals. Patients were consecutively selected from each local multiple sclerosis patients´ database. Sociodemographic and initial clinical data were collected through a questionnaire. Date of final diagnosis and multiple sclerosis classification was obtained from clinical files.Results: A total of 285 patients were included with mean age at diagnosis of 36 years. The median time between first clinical manifestation and multiple sclerosis diagnosis was nine months (IQR 2 - 38). Diagnostic delay was associated with an older age (p < 0.001; r = 0.35), motor deficit at onset [26.5 months (IQR 4.5 - 56.5); p = 0.0005], higher number of relapses before diagnosis (p < 0.001; r = 0,626), first observation by other medical specialty [11 months (IQR 2 - 48); p < 0.001], prior alternative diagnosis [20 months (IQR 4 - 67.5); p < 0.001] and primary progressive subtype [37 months (IQR 25 - 64.5); p < 0.001]. The most significant delay occurred between the initial symptom and neurological observation.Discussion: A significant delay occurred between initial symptoms and the diagnosis of multiple sclerosis, reflecting the need toincrease awareness of this entity and its diverse symptom presentation.

show abstract

“…Adult patients with MS, diagnosed according to McDonald criteria [27], corresponding to ICD-10 code G35.0 were enrolled in the study. Patients were excluded if they were in acute phase and if they had severe cognitive disorders.…”

Section: Selection Criteriamentioning

confidence: 99%

Functioning and disability in multiple sclerosis

Švestková

Angerová

Sládková

et al. 2010

Disability and Rehabilitation

View full text Add to dashboard Cite

The ICF can be successfully implemented in clinical and rehabilitation of patients with MS, because it enables to describe its multiple facets. Little differences between capacity and performance in ICF categories connected with activities of daily living, and presence of technical aids and other environmental factors are reported. On the contrary, in categories related to relationships, performance was worse than capacity thus revealing attitudinal barriers.

show abstract

The diagnosis of multiple sclerosis

Cited by 19 publications

References 0 publications

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions

Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions

Diagnostic Delay of Multiple Sclerosis in a Portuguese Population

Functioning and disability in multiple sclerosis

Contact Info

Product

Resources

About