The Diagnosis of Cancer of the Pancreas, Biliary Tract, and Duodenum by Combined Cytologic and Secretory Methods

Wenger, Julius; Raskin, Howard F.

doi:10.1016/s0016-5085(58)80075-x

Cited by 47 publications

(4 citation statements)

References 6 publications

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“…It was not until Agren and Lagerlof (1936), who used a purified preparation of secretin, adopted the double lumen tube method of Lim, Matheson, and Schlapp (1923) to obtain uncontaminated specimens of duodenal juice that accurate quantitative measurements of pancreatic function could be made. Since that time the technique elaborated by Agren and Lagerlof has been closely followed by other workers and the value of the secretin test in assessing pancreatic function in man confirmed (Lagerlof, 1939(Lagerlof, , 1942Diamond, Siegel, Gall, and Karlen, 1939;Diamond andSiegel, 1940, 1941;Comfort and Osterberg, 1940;Pratt, Brugsch, and Rostler, 1940;Pollard, Miller, and Brewer, 1942;Lake, 1947;Dornberger, Comfort, Wollaeger, and Power, 1948;Dreiling andHollander, 1948, 1950;Friedman and Snape, 1950;Dreiling, 1950Dreiling, , 1951Dreiling, , 1953Dreiling, , 1955Dreiling and Janowitz, 1957;Wenger and Raskin, 1958).…”

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confidence: 84%

A Test of Pancreatic Function in Man Based on the Analysis of Duodenal Contents after Administration of Secretin and Pancreozymin

Burton¹,

Evans²,

Harper³

et al. 1960

Gut

190

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Pancreozymin in man as in animals appears to act as a specific enzyme stimulant. The preparations of pancreozymin used in these experiments also contain cholecystokinin, which causes the gall bladder to contract, and a smooth muscle stimulant, possibly substance P.The (Lagerlof, 1939(Lagerlof, , 1942 Diamond, Siegel, Gall, and Karlen, 1939;Diamond andSiegel, 1940, 1941;Comfort and Osterberg, 1940;Pratt, Brugsch, and Rostler, 1940;Pollard, Miller, and Brewer, 1942;Lake, 1947;Dornberger, Comfort, Wollaeger, and Power, 1948;Dreiling and Hollander, 1948, 1950;Friedman and Snape, 1950;Dreiling, 1950Dreiling, , 1951Dreiling, , 1953Dreiling, , 1955 Dreiling and Janowitz, 1957;Wenger and Raskin, 1958).In anaesthetized animals secretin produced a large volume of pancreatic juice of constant alkalinity and low enzyme content. Harper and Raper (1943) isolated from the small intestine a second material, other than secretin, which increased the enzyme output by the pancreas without affecting the volume of juice. This material they named pancreozymin. Crick, Harper, and Raper (1949) later published a revised method of preparing secretin and pancreozymin and preliminary experiments showed that pancreozymin had the same effect on man as in animals

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confidence: 84%

A Test of Pancreatic Function in Man Based on the Analysis of Duodenal Contents after Administration of Secretin and Pancreozymin

Burton¹,

Evans²,

Harper³

et al. 1960

Gut

190

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“…Similar experiences were reported by Bolgert (1948) in France and by Dubois (1952) in Switzerland. In recent years the value of the secretin test has been amply demonstrated through the extensive studies of Dreiling and Janowitz Wenger and Raskin (1958) in Chicago, and Shay (1957, 1960) Shay et al (1961) in Philadelphia, particularly since it has been shown that cancer of the pancreas (Dreiling et al 1960, the gallbladder and the bile ducts (Dreiling et al 1960) and to a certain extent also some processes involving the liver (Henning et ul. 19150) can be diagnosed by means of exfoliative cytology on the duodenal contents after secretin injection preferably combined with a cholecystokinin-pancreozymin test.…”

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confidence: 99%

On the Biological Assay of Secretin. The Reference Standard

Jorpes

Mutt

1966

Acta Physiologica Scandinavica

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JORPES, J. E. and V. MUTT. On thc biological assay of secretin. The referince standard. Acta physiol. scand. 1966. 66. 316-325. --The authors discuss the methods in use for the assay of secretin preparations in dogs, cats and rats. A detailed description is given of the method of Mutt and Soderberg, maintaining the cats anesthetized continuously for 4-5 days. Particular attention is paid to recent methods using rats for the secretin assay. The numerical values of the different secretin units, suggested by different authors, are discussed. The difficulties encountered in selecting a reference standard are discussed. The authors recommend frequent controls of the strength of the standard with any of the familiar techniques.From the days in 1926 when Chiray and his coworkers (Chiray et al. 1926, 1930: Chiray and Bolgert 1936 Rolgert 1935) in France introduced secretin, as prepared by Penau and Simonnet (1925), as a diagnostic tool in medicine numerous attempts have been made to obtain stable secrrtin preparations to be used as reference standard in the study of the secretory capacity of the pancreatic gland. I n general the field seemed to be inaccessible. Poorly stable preparations with only a few clinical units of secretin activity per mg and giving side reactions w-ere mostly obtained. The pharniaceutical houses, @la, Paris, A4Jtru: Sodertalje, Sweden, and Wjeth Co., Philadelphia, also soon dropped their manufacture of secretin while the Eli Lilly Cornpan)-. Indiana-

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“…Es handelt sich dabei also um ein praoperatives diagnostisches Verfahren, das auch yon anderen Autoren [23], z. T. mit recht guten Ergebnissen, bereits erprobt worden ist, und das in der allerjiingsten Zeit sogar gezielt unter duodenoskopischer Sicht durchzufiihren angeregt wurde [14]. b) Die cytologische Untersuchung yon Ausstrichen, die durch Zentrifugieren von Pankreassaft gewonnen werden, der intraoperativ abgesaugt wird.…”

Section: Die Ver/ahren Der Pankreasgangcytologieunclassified

Das Problem der intraoperativen Abkl�rung von Pankreaskopftumoren

Bodner

1973

Langenbecks Arch Chiv

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Through observation of our own patients we have analyzed the problem of differential diagnosis of tumours of the head of the pancreas during operation and have found out that even by means of modern pre-operative examination techniques a clear distinction between carcinomata and chronic panereatitis cannot be achieved. Therefore the final diagnostic decision in these cases is left to the surgeon to be taken during operation. The reservations, generally brought forward against the histological methods of pancreas biopsy (sample excision and Menghini-puncture) because of their low degree of accuracy and high risk of complication, must be confirmed according to our own experience (out of 35 carcinomata, positively diagnosed at a later stage, only 16 had been detected immediately whereas 19 had produced wrong negative results; in 15 cases out of 37 complications had arisen, among them one death). Thus we were looking for adequate methods of cytological diagnosis. Good results could be achieved particularly with curettage of the pancreatic duct and with fine.needle aspiration biopsy (out of t9 carcinomata li definite and 4 suspected positive results). It should be emphasized that so far * Herrn Prof. Dr. W. Baumgartner wird fiir die stiindige FSrderung und das Interesse, das er der vorliegenden Arbeit entgegengebracht hat, herzlich gedankt. Mein Dank gilt auch den Herren Prof. Dr. A. Propst (Vorstand des Pathologischanatomischen Instituts der Universit~t Innsbruck) und Doz. Dr. B. Lederer fiir die morphologische Beurteilung und Befunddokumentation. Teile der Arbeit wurden in Zusammenarbeit mit dem Gastroenterologischen Labor unserer Klinik und mit Unterstiitzung des Fonds zur FSrderung der wissenschaftlichen Forschung in 0sterreich durchgeffthrt. Daf/ir habe ich Herrn Prof. Dr. H. Reissigl und Herrn Dr. :N. Falser zu danken. Schlielllich sei auch Herrn Doz. Dr. E. Semenitz, durch dessen Entgegenkommen die Tierversuche ermSglicht wurden, mein Dank ausgesprochen.

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The Diagnosis of Cancer of the Pancreas, Biliary Tract, and Duodenum by Combined Cytologic and Secretory Methods

Cited by 47 publications

References 6 publications

A Test of Pancreatic Function in Man Based on the Analysis of Duodenal Contents after Administration of Secretin and Pancreozymin

A Test of Pancreatic Function in Man Based on the Analysis of Duodenal Contents after Administration of Secretin and Pancreozymin

On the Biological Assay of Secretin. The Reference Standard

Das Problem der intraoperativen Abkl�rung von Pankreaskopftumoren

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