The Diagnosis and Treatment of Primary Osteoporosis According to Current Guidelines

Abstract

The indication for dual X-ray absorptiometry (DXA) measurement for the specific diagnosis of osteoporosis is derived from the patient's age, sex, history of fractures in the past, and further risk factors. The therapeutic threshold for osteoporosis has been set at a 30% predicted risk of osteoporotic fractures occurring within 10 years. The treatment consists of basic measures for fracture prevention combined with specific pharmacotherapy. The recommended drugs for the treatment of osteoporosis in postmenopausal women in particular are alendronic and ibandronic acid, raloxifen, risedronic acid, and strontium ranelate; the only approved drugs for men at present are alendronic and risedronic acid and teriparatid. Intensive patient education markedly improves the otherwise poor compliance with osteoporosis treatment.

Osseofix® System for Percutaneous Stabilization of Osteoporotic and Tumorous Vertebral Compression Fractures – Clinical and Radiological Results After 12 Months

“…We saw one case of adjacent vertebral fracture (2.2 %) during the follow-up examination after 12 months. This is a good result compared to the adjacent fracture rates of 0 -8 % for vertebroplasty and 25 -26 % for kyphoplasty (follow-up period of 3 -12 months) for stabilized osteoporotic vertebral compression fractures [10,27] and 0 -18 % [6, 28] for vertebroplasty and 2.9 -18 % for kyphoplasty (follow-up period of 9 -12 months) for stabilized tumorous vertebral fractures [6,17,28]. This may indicate a change in the biomechanics of a vertebral body stabilized with the Osseofix ® system compared to one stabilized exclusively with bone cement [11].…”

“…A bisphosphonate medication prescribed by us was still being taken after 12 months by 56 % of the patients with osteoporotic vertebral fracture and 100 % of the patients with tumorous vertebral fracture. Baum and Peters [28] reported a continuation rate of bisphosphonate medication of 62 % 12 months after the completion of intensive osteoporosis training. We saw one case of adjacent vertebral fracture (2.2 %) during the follow-up examination after 12 months.…”

The gaps between patient and physician understanding of the emotional and physical impact of osteoporosis

“…Affecting more than 200 million people worldwide [2], it has become a major health care issue. It results not only in loss of bone mass, but significant problems with respect to functional status and quality of life, including physical, functional and psychosocial impairment, morbidity and mortality [3].…”

Repercussões minerais ósseas no alcoolismo crônico associado à deficiência hormonal em ratos

“…Acrescentando a este, outro fator negativo como a idade avançada e a osteoporose, as fraturas tendem a ter um tempo maior de reparo e as manifestações clínicas o pior prognóstico (Christodoulou;Close et al, 2003;Baum;Peters, 2008 (Gali, 2001;Sampson, 2002;Lane, 2006;Liu et al, 2008;Metcalfe, 2008;Moayyeri et al, 2009;Pinheiro et al, 2009). …”