The diagnosis and surgical management of major salivary gland pathology

Lawler, B.; Pierce, Angela; Sambrook, Paul; Jones, R. Clark; Goss, AN

doi:10.1111/j.1834-7819.2004.tb00043.x

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Taken together, our functional results share some clinical features with human AS or SS. Specifically, the condition is caused by S. aureus and is characterized by acute pain, swelling and xerostomia and commonly observed in hospitalized patients 2 6 40 . It would be tempting to speculate that patients with AS or SS may have functional alteration of the ALX/FPR2; however, future studies are needed to confirm this notion.…”

Section: Resultsmentioning

confidence: 99%

ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland

Wang

Wee

Yang

et al. 2016

Sci Rep

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Activation of the G-protein coupled formyl peptide receptor 2 (ALX/FPR2) by the lipid mediators lipoxin A4 and resolvin D1 (RvD1) promotes resolution of inflammation. Our previous in vitro studies indicate that RvD1 activation of ALX/FPR2 resolves cytokine-mediated inflammatory responses in mammalian cells. However, the impact of ALX/FPR2 activation on salivary gland function in vivo is unknown. The objective of this study was to determine whether submandibular glands (SMG) from ALX/FPR2−/− mice display enhanced inflammatory responses to lipopolysaccharides (LPS) stimulation. For these studies, C57BL/6 and ALX/FPR2−/− mice at age 8-12-week-old were treated with LPS by i.p for 24 h. Salivary gland structure and function were analyzed by histopathological assessment, saliva flow rate, quantitative PCR, Western blot analyses and immunofluorescence. Our results showed the following events in the ALX/FPR2−/− mice treated with LPS: a) upregulated inflammatory cytokines and decreased M3R (Muscarinic Acetylcholine receptor M3) and AQP5 (Aquaporin 5) protein expression, b) decreased saliva secretion, c) increased apoptosis, d) alteration of tight junction and neuronal damage. Overall, our data suggest that the loss of ALX/FPR2 results in unresolved acute inflammation and SMG dysfunction (xerostomia) in response to LPS that is similar to human salivary gland dysfunction induced by bacterial infection.

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Section: Resultsmentioning

confidence: 99%

ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland

Wang

Wee

Yang

et al. 2016

Sci Rep

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“…Chaudhary 21 Psychosocial stressors in oral lichen planus. Lawler, Pierce, et al 22 The diagnosis and surgical management of major salivary gland pathology. Robinson, Wray 23 Desquamative gingivitis: A sign of mucocutaneous disorders -a review.…”

Section: Australian Dental Journalmentioning

confidence: 99%

Oral medicine in Australia 2000–2010. A publications overview

Savage

2010

Australian Dental Journal

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Specialties within health care are often identified by the public profile provided by members within the private clinical practice arena. This is clearly important but often the real activity of a specialty discipline exists within the training institutions. This is an unseen area for most, both members of the public as well as professional colleagues, as papers reporting developments of all kinds are delivered to highly specific target audiences and publications reporting research are published in journals again targeting specific audiences. Publication in national journals is important and provides a glimpse of research activities and a wealth of clinical material in the form of reviews and case reports directed again to a specific target audience. This paper addresses the profile of oral medicine in Australia by presenting the papers published in the Australian Dental Journal within a 10-year bracket.

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“…(a) Patient with parotid swelling. Reproduced with permission from the Australian Dental Journal . (b) Diagram of the parotid gland (black) and facial nerve (red).…”

Section: Introductionmentioning

confidence: 99%

“… OPG showing stone in the submandibular gland. Reproduced with permission from the Australian Dental Journal …”

Section: Introductionmentioning

confidence: 99%

The management of benign salivary disease: a case series

Jones

Findlay

2013

Australian Dental Journal

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There are many causes for benign salivary gland disease but the most common relate to inflammation and infection. This usually revolves around duct obstruction and a reduction in the normal salivary flow from the gland into the mouth. This leads to retention of saliva, proximal to the obstruction and ascending infection from the mouth, usually because of the decrease in salivary flow. The increase in tension behind the obstruction causes significant pain and swelling, along with the inevitable infection if the obstruction is not relieved. This paper discusses the various treatments available for benign salivary gland disease, the traditional methods of treatment through to the use of endoscopic techniques which are currently available, including a discussion about the use of sialoendoscopy.

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The diagnosis and surgical management of major salivary gland pathology

Cited by 3 publications

References 4 publications

ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland

ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland

Oral medicine in Australia 2000–2010. A publications overview

The management of benign salivary disease: a case series

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