The diabetogenic and acidotropic effects of chelators

Study of the pathogenesis and treatment of diabetes mellitus through animal models

“…The most commonly chosen are STZ and alloxan, although others, like vacor or dithizone, have also been used [103,222,223].…”

Development of Improved Animal Models for the Study of Diabetes

“…Administration of this chelator in rabbit has a particular effect expressed as initial hyperglycemia after 2 hours, followed by normoglycemia in 8 hours and finalized by permanent hyperglycemia due to degranulation of β-cells [29].…”

Effect of chelating agents and stress factors on zinc content in Paneth cells and prostate gland cells

“…Complexes of chelating agents with metals (chelates) are products and wastes of chemical, pharmaceutical, and other branches of industry [1,2,4]. Many drugs belonging to this family of compounds in vivo may interact with cellular zinc and induce cell changes [2,4].…”

“…Many drugs belonging to this family of compounds in vivo may interact with cellular zinc and induce cell changes [2,4].…”

“…and supports structural integrity and function of cell membranes [3,4]. Administration of dithizone (chelating agent) is followed by zinc binding in animal β-cells and their injury, while another chelating agent sodium diethyldithiocarbamate (DDC) does not induce damage despite zinc binding in these cells [2,4].…”