The Development of Thyroid Function in the Rat

Hommes, F. A.; Wilmink, C.W.; Richters, Anke

doi:10.1159/000240171

Cited by 23 publications

(15 citation statements)

References 4 publications

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“…Their assumption that radioiodine is fully equilibrated 48 h after its administration is apparently not true. Because the young rat is not hypothyroid we support the findings of H emon [1] that thyroid hormone induces the activity of malate and a-glycerophosphate dehydrogenase and also of NADP-dependent isocitric dehydrogenase [2] in rat liver.…”

Section: Discussionsupporting

confidence: 87%

Effect of Varying Iodine Intake on its Concentration in Rat Tissues during Early Development

Štolc¹,

Knopp²,

Stolcova³

1973

Neonatology

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From the day of parturition, three groups of lactating rats and their young were kept on a laboratory diet containing 60 ng iodine/g of food and drank water with an iodine concentration of 5, 100 and 500 ng/ml, respectively. The first two groups of sucklings showed a relatively decreasing and the third a relatively increasing iodine intake (μg I/day/100 g body weight). Iodine intake in food was found to affect iodine concentration but had no effect on its decline in the tissues during postnatal life. Consequently, it is presumed that this decline is genetically controlled.

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Section: Discussionsupporting

confidence: 87%

Effect of Varying Iodine Intake on its Concentration in Rat Tissues during Early Development

Štolc¹,

Knopp²,

Stolcova³

1973

Neonatology

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“…This higher rate of supply of acetyl-CoA, which is not further metabolized in the tricarboxylic acid cycle, makes it likely that this intermediate is more used for synthetic reactions. The earlier demon strated higher activity of the NAD P specific isocitrate dehydrogenase [11] is also an indication that in fetal liver the mitochondria serve more an anabolic purpose than a catabolic one. B a l la r d and H an so n [30] have shown that fetal rat liver, close to term, contained much higher amounts of cholesterol and triglycerides than adult rat liver.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, it could be shown that the activity of malate dehydrogenase of mitochondria is constant as a function of age [10]. The activities of the N A D -and NAD P dependent isocitric dehydrogenases could be related with the thyroid state of the developing rat [11]. No data are, however, avail able on the development of citrate synthase (condensing enzyme), aconitase, 2-ketoglutarate dehydrogenase and fumarase, the remaining enzymes of the tricarboxylic acid cycle.…”

mentioning

confidence: 99%

The Development of some Krebs Cycle Enzymes in Rat Liver Mitochondria

Hommes¹,

Haan²,

Richters³

1971

Neonatology

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“…The second increase in creatine kinase activ ity (31) occurs simultaneously with a rise in plasma thyroxine levels (28,40). A transient increase in the plasma thyroxine level between 12 and 20 days of age has been observed by Partridge et al (40).…”

Section: Thyroxinementioning

confidence: 90%

Effect of Hormones on the Development of Creatine Kinase Activity in Rat Skeletal Muscle

Kloosterboer¹,

Faassen²,

Vries³

et al. 1979

Neonatology

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Various approaches have been used in order to determine whether or not a certain hormone is a stimulus for the development of the muscle-specific enzyme, creatine kinase. Both thyroxine and glucocorticoids can be considered as naturally occurring stimuli for the synthesis of creatine kinase. The maximum increase of creatine kinase activity after stimulation by glucocorticoids (about 25%) occurs between 5 and 7 days after birth. A single injection of thyroxine has virtually no effect during this period. However, when a pretreatment with thyroxine is given, cortisone acetate administration increases creatine kinase activity to about 155%. The effect of cortisone acetate is due to de novo synthesis of creatine kinase. The augmentation of the effect of cortisone acetate by thyroxine is dependent on DNA synthesis. Thyroxine administration apparently causes the formation of more competent muscle cells. The effects of both hormones are age-dependent. Thyroxine and cortisone acetate administration to fetuses can prematurely evoke the MM isoenzyme of creatine kinase. Both hormones probably play a role in the activation of the M gene during embryonic development. Sex hormones are able to influence neither creatine kinase activity nor muscle growth. However, castration of male rats immediately after birth causes an impairment of growth at older ages. The androgen production by the testes immediately after birth seems to be of main importance for body growth and development. It can be concluded from these results that creatine kinase in muscle is under multiple hormonal control, just as is observed for a number of enzymes in other tissues.

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The Development of Thyroid Function in the Rat

Cited by 23 publications

References 4 publications

Effect of Varying Iodine Intake on its Concentration in Rat Tissues during Early Development

Effect of Varying Iodine Intake on its Concentration in Rat Tissues during Early Development

The Development of some Krebs Cycle Enzymes in Rat Liver Mitochondria

Effect of Hormones on the Development of Creatine Kinase Activity in Rat Skeletal Muscle

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