“…A sustainable food production system should be established which can solve the contradiction between the growing population and the continuous decline in per capita arable area. , With the occurrence of pests and diseases, it is very essential for extensive application of a large number of pesticides, and the increase of pesticide resistance, however, has brought huge obstacles to the sustainable development of food production. − Therefore, development of efficient and safe pesticides is urgently needed. , Recently, the use of natural bioactive products as the lead structures for further modification has received much attention for the development of pesticide candidates. − Honokiol ( 1 , Figure ), as a biphenyl polyphenol-type compound isolated from the traditional Chinese medicine Magnolia officinalis, , showed a variety of properties such as anticancer, antioxidative, antiviral, antimicrobial, and anti-inflammatory activities . In recent years, studies on the structural modification of honokiol to obtain drug or pesticide candidates with excellent biological activities have been reported. , Previously, we synthesized a series of honokiol azo derivatives ( A , Figure ), honokiol benzoxazole derivatives ( B , Figure ), and honokiol arylmethylamine derivatives ( C , Figure ) as insecticidal agents against Mythimna separata Walker and found that some compounds exhibited good insecticidal activities; however, their activities are far from being comparable to those of traditional agrochemicals.…”