The development of the paraphysis cerebri in man with comments on its relationship to the inter‐columnar tubercle and its significance for the origin of cystic tumors in the third ventricle

Kappers, J. Ariëns

doi:10.1002/cne.901020205

Cited by 111 publications

(21 citation statements)

References 21 publications

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“…Further, our data suggest that the rhombic lip makes a direct contribution to the hCPe at later stages. This model differs from the previously accepted view of a linear progression in development, in which the rhombic lip is the source of non-mitotic roof plate cells that transform to form hCPe in its entirety (Dohrmann, 1970;Dziegielewska et al, 2001;Kappers, 1955;Sturrock, 1979;Thomas and Dziadek, 1993;Wilting and Christ, 1989). In this conservative model, the increased epithelial surface area crucial to hCPe function arises solely from changes in cell shape -a densely packed pseudostratified RPe spreads out into a simple monolayered cuboidal epithelium.…”

Section: Discussionmentioning

confidence: 82%

“…Furthermore, hCPe, like hRPe, appears to comprise lineagerestricted compartments (Awatramani et al, 2003). A linear progression in development has been assumed, with the rhombic lip producing non-mitotic hRPe, and hRPe transforming into the more expansive hCPe (Thomas and Dziadek, 1993;Wilting and Christ, 1989) without cell gain (Dziegielewska et al, 2001;Kappers, 1955;Sturrock, 1979). The enormous increase in surface area of hCPe Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus versus hRPe has been viewed as arising solely through changes in cell shape -densely packed pseudostratified hRPe spreads out to form the simple cuboidal hCPe (Dohrmann, 1970).…”

Section: Introductionmentioning

confidence: 99%

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Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Hunter

Dymecki

2007

Development

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Both hindbrain roof plate epithelium (hRPe) and hindbrain choroid plexus epithelium (hCPe) produce morphogens and growth factors essential for proper hindbrain development. Despite their importance, little is known about how these essential structures develop. Recent genetic fate maps indicate that hRPe and hCPe descend from the same pool of dorsal neuroectodermal progenitor cells of the rhombic lip. A linear developmental progression has been assumed, with the rhombic lip producing non-mitotic hRPe, and seemingly uniform hRPe transforming into hCPe. Here, we show that hRPe is not uniform but rather comprises three spatiotemporal fields, which differ in organization, proliferative state, order of emergence from the rhombic lip, and molecular profile of either the constituent hRPe cells themselves and/or their parental progenitors. Only two fields contribute to hCPe. We also present evidence for an hCPe contribution directly by the rhombic lip at late embryonic stages when hRPe is no longer present; indeed, the production interval for hCPe by the rhombic lip is surprisingly extensive. Further, we show that the hCPe lineage appears to be unique among the varied rhombic lip-derived lineages in its proliferative response to constitutively active Notch1 signaling. Collectively, these findings provide a new platform for investigating hRPe and hCPe as neural organizing centers and provide support for the model that they are themselves patterned structures that might be capable of influencing neural development along multiple spatial and temporal axes.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Hunter

Dymecki

2007

Development

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“…choroid plaque; Figs 4, 6). In humans and other species, the tCPe and dCPe appear continuous, but morphological studies have suggested that they form separately and then become continuous secondarily (Dziegielewska et al, 2001;Kappers, 1955). To study the tCPe and dCPe fields in developing mice with a molecular marker, we examined Ttr expression in serial coronal sections.…”

Section: The Tcpe and Dcpe Emerge From Separate Developmental Fieldsmentioning

confidence: 99%

Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation

et al. 2005

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Choroid plexus (CP) produces the cerebrospinal fluid (CSF) of the central nervous system (CNS), but little is known about the mechanisms underlying development of this important tissue. CP forms in the hindbrain (4th ventricle), diencephalon (3rd ventricle) and dorsomedial telencephalon bilaterally (lateral ventricles). All of these sites lie at or near the embryonic dorsal midline (DM), which acts as a CNS patterning center. We therefore examined DM-CP relationships using normal and Gdf7 (Bmp12)transgenic embryos to fate map or ablate DM cells. These studies revealed a Gdf7 fate map that includes most CP epithelial (CPe) cells of the hindbrain and diencephalon. In the telencephalon, Gdf7 cell lineages were found in the small anterior domain of telencephalic CPe (tCPe), but its large posterior domain was devoid of these lineages. Anterior and posterior tCPe domains,which arise within a contiguous field separate from diencephalic CPe, also exhibited different patterns of apoptosis. Despite lacking Gdf7 cell lineages,the posterior tCPe domain failed to form after ablating Gdf7-expressing DM cells at neural tube stages. The tCPe loss was associated with abrogation of high-level bone morphogenetic protein (Bmp) signaling, which is known to be required for tCPe induction. Taken together, these studies demonstrate intimate DM-CPe relationships throughout the CNS and highlight two distinct tCPe domains, including a posterior domain whose genesis depends on DM cells in a non-cell-autonomous fashion.

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“…10 The first documented case of colloid cyst was observed in 1858, and since after that time there has been controversy regarding its origin 11 , various authors have reported different sites of origin. 12,13,14 Colloid cyst produces non localizing symptoms with increase in the intracranial pressures such as visual disturbance, vomiting, gait ataxia and paroxysmal headaches associated with change in head position. 1,4,5,6,7,8 N= 2 patients in our study had normal pressure hydrocephalus, which shows rapid neurological deterioration after a lumbar puncture and may even lead to death, hence early detection and treatment of colloid cysts is important in such patients.…”

Section: Discussionmentioning

confidence: 99%

Colloid Cyst

Khan

Ali

Imran

et al. 2018

TPMJ

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ABSTRACT… Context: Colloid cyst is a rare tumour of the brain that has a good outcome upon surgical removal. Aims: We present the outcome of surgical management of colloid cyst at our setup based on the experience of last ten years. Study Design, Setting and Period: The type of study is a retrospective review of cases of third ventricular colloid cyst operated at the Department of Neurosurgery, Civil Hospital Karachi, Pakistan, from January 2005 to December 2015. Methods and Material: The patient's data including the clinical records, radiographic data, operative and follow up notes were studied. The patient population was divided into groups based upon the size of the cyst. The surgical approaches utilized were the transfrontal transventricular and transcallosal approach. All the patients also underwent a series of tests to determine the function of the somatosensory, motor and memory functions both pre and post operatively and upon follow up. Statistical analysis used: Data was analyzed using SPSS version 23. Mean and standard deviation was used for continuous variables, while frequency and percentage was used for categorical variables. Results: The study population n= 60 patient, n= 36 males and n= 24 females. The size distribution of the cyst was, n= 4 (6.66%) were less than 1.5cm, n=47 (78.33%) were 1.5-3cm and n=9 (15%) were >3cm. Headache was the most common presenting complaint. Papilledema was observed in 71.66% of the patients, while memory changes were observed in 8.33% of the patients. The surgical excision of the cyst was performed in n= 52, patients while ventriculoperitoneal shunt was performed in n= 8 patients. Conclusions: According to the results of our study the transcallosal approach, is a safe technique, in which the neurological damage is limited due to minimal callosotomy and manoeuvring of the fornix.

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The development of the paraphysis cerebri in man with comments on its relationship to the inter‐columnar tubercle and its significance for the origin of cystic tumors in the third ventricle

Cited by 111 publications

References 21 publications

Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation

Colloid Cyst

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