The Development of the Interstitial Cells in the Testis of the Albino Rat

Mitotic activity in monkey and rat Leydig cells

“…Tissue preparation. -As previously described (Fouquet et al, 1984 ;Fouquet, 1987) (Christensen, 1975 Anderson, 1959) and in young mice (Baillie, 1961 ;Hitzeman, 1962) Kormano, 1964 ;Okada, 1970), whereas no labeling was detected at the same age (1 to 21 days) in semi-thin plastic sections (Orth, 1982). these different results might be related to preparative methods but more probably to Leydig cell identification which was more reliable in the latter work.…”

“…It is also believed that Leydig cells are able to divide (Christensen, 1975). Certainly, interstitial cells show mitotic activity during normal development (Roosen-Runge and Anderson, 1959 ;Baillie, 1961 ;Hitzeman, 1962 ;Gondos et al, 1977) and this activity increases during various experimental conditions (Chemes et al, 1976 ;Aoki and Fawcett, 1978 ;Kerr et al, 1979 ;Christensen and Peacock, 1980). However, mitotic Leydig cells have been actually identified only in cryptorchid rats (Kerr et al, 1979).…”

Neonatal-Prepubertal Hypothyroidism on Postnatal Testis Development

“…Leydig cells in the adult testis, which are identified as the mature adult Leydig cells are differentiated postnatally during the neonatal pre-pubertal period (Roosen-Runge and Anderson, 1959;Mancini et al, 1963;Niemi and Kormano, 1964;Baillie, 1964;Lording and de Kretser, 1972;Mendis-Handagama et. al., 1987;Ariyaratne et al, 2000d) from the peritubular mesenchymal cells (Figure 6), which are the stem cells of adult Leydig cells.…”

Mechanisms of aging in relationship to steroid biotransformations and the thiobarbituric acid reactive material in rate testicular tissue in vitro

“…They comprised 9 per cent of the testis volume on the 19th day of fetal life, but the adult value was not greater than 2 per cent (Roosen-Runge and Anderson, 1959). The description by Roosen-Runge and Anderson (1959) suggested a biphasic pattern in the Leydig cell population, with maxima that occurred during fetal life and at adulthood. The minimum cell count occurred during the first few days after birth.…”

“…Another increase was evident at puberty through redifferentiation of the fibroblast-like elements and not by their cell division (Mancini et al, 1963;Niemi and Kormano, 1964). The first maximum in the number of the Leydig cells occurred at 19 days of embryonary life in the rat (Roosen-Runge and Anderson, 1959), at midterm in the horse (Gillman, 1948), at 6 months in humans (Mancini et al, 1963), and immediately after birth in the rabbit (Allen, 1904) and boar (Bascom and Osterund, 1927). In the rat, the minimum number of interstitial cells existed between 6 and 26 days post-partum (Roosen- Runge and Anderson, 1959).…”