The development of the dorsal mesentery in human embryos and fetuses

Hikspoors, Jill P. J. M.; Kruepunga, Nutmethee; Peeters, Jean-Marie P.W.U.; Hülsman, Cindy J. M.; Köhler, S. Eleonore; Lamers, Wouter H.

doi:10.1016/j.semcdb.2018.08.009

Cited by 14 publications

(16 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The primary midgut loop, which is formed during midgut herniation into the umbilical cord at week 5, as mentioned before, contains only one part of the colon, the cecum, which is part of the 4th secondary ileocecal loop of the distal limb (114). The colon develops 2-fold at a slower rate than the small intestine, in accordance with its dorsal mesentery and does not require to loop (115). Before the resolution of the hernia, the intra-abdominal part of colon and its dorsal mesentery is sagittally positioned in the midline of abdomen.…”

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 93%

“…Before the resolution of the hernia, the intra-abdominal part of colon and its dorsal mesentery is sagittally positioned in the midline of abdomen. Between weeks 8.5 and 9.5 of gestation, the development rate of both small and large intestine significantly decreases (115), whereas the body axis and wall growth create enough space to drive midgut back inside abdomen (116). As the midgut returns inside the abdomen, the duodenum is placed dorsocaudally to the superior mesenteric artery (SMA) at the left side and jejunum occupies most of the left side.…”

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 99%

“…As the midgut returns inside the abdomen, the duodenum is placed dorsocaudally to the superior mesenteric artery (SMA) at the left side and jejunum occupies most of the left side. Τhe ileocecal loop is the last to return inside the abdomen at week 9.5, and becomes positioned initially ventrally at the midline and half a week later it can be found in the right side (115).…”

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 99%

“…As far as the colon is concerned, at 10 weeks of gestation, directly following the resolution of the umbilical hernia, the ascending and descending colon initially adhere to the dorsal body wall and their dorsal mesentery gradually fuses irreversibly with the parietal peritoneum, which line the internal surface of the abdominal cavity. In such a manner, the cranial part of the ascending colon attaches to the ventral surface of the duodenum and the mesentery extends downwards and leftward, while the greater omentum attaches to the ventral side of the transverse colon and the descending colon mesenteric fusion begins cranially and continues caudally (115,143). The product of fusion, Toldt's fascia or membrane mesenterii propria, contains nerves, blood and lymphatic vessels, lymph nodes and fat tissue (144).…”

Section: Mesenteric Fixationmentioning

confidence: 99%

See 3 more Smart Citations

Large intestine embryogenesis: Molecular pathways and related disorders (Review)

et al. 2020

View full text Add to dashboard Cite

The large intestine, part of the gastrointestinal tract (GI), is composed of all three germ layers, namely the endoderm, the mesoderm and the ectoderm, forming the epithelium, the smooth muscle layers and the enteric nervous system, respectively. Since gastrulation, these layers develop simultaneously during embryogenesis, signaling to each other continuously until adult age. Two invaginations, the anterior intestinal portal (AIP) and the caudal/posterior intestinal portal (cIP), elongate and fuse, creating the primitive gut tube, which is then patterned along the antero-posterior (AP) axis and the radial (RAd) axis in the context of left-right (LR) asymmetry. These events lead to the formation of three distinct regions, the foregut, midgut and hindgut. All the above-mentioned phenomena are under strict control from various molecular pathways, which are critical for the normal intestinal development and function. Specifically, the intestinal epithelium constitutes a constantly developing tissue, deriving from the progenitor stem cells at the bottom of the intestinal crypt. Epithelial differentiation strongly depends on the crosstalk with the adjacent mesoderm. Major molecular pathways that are implicated in the embryogenesis of the large intestine include the canonical and non-canonical wingless-related integration site (Wnt), bone morphogenetic protein (BMP), Notch and hedgehog systems. The aberrant regulation of these pathways inevitably leads to several intestinal malformation syndromes, such as atresia, stenosis, or agangliosis. Novel theories, involving the regulation and homeostasis of intestinal stem cells, suggest an embryological basis for the pathogenesis of colorectal cancer (cRc). Thus, the present review article summarizes the diverse roles of these molecular factors in intestinal embryogenesis and related disorders.

show abstract

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 93%

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 99%

Section: Molecular Control Of the Left-right (Lr) Patternmentioning

confidence: 99%

Section: Mesenteric Fixationmentioning

confidence: 99%

See 2 more Smart Citations

Large intestine embryogenesis: Molecular pathways and related disorders (Review)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the embryo, the coelomic cavity extends down to the muscles of the pelvic floor, as it still does in all adult quadrupeds. In humans, however, this downward extension of the peritoneal cavity disappears in much the same way as the ascending and descending portions of the colon become retroperitoneal (Hikspoors et al, ). Denonvilliers’ fascia has, therefore, the same origin as Toldt's fascia in the abdomen (Toldt, ; Tobin and Benjamin, ).…”

Section: New Findingsmentioning

confidence: 99%

Interactive three‐dimensional teaching models of the female and male pelvic floor

Hikspoors

Dabhoiwala

et al. 2019

Clinical Anatomy

Self Cite

View full text Add to dashboard Cite

Controversies regarding structure and function of the pelvic floor persist because of its poor accessibility and complex anatomical architecture. Most data are based on dissection. This "surgical" approach requires profound prior knowledge, because applying the scalpel precludes a "second look." The "sectional" approach does not entail these limitations, but requires segmentation of structures and threedimensional reconstruction. This approach has produced several "Visible Human Projects." We dealt with limited spatial resolution and difficult-to-segment structures by proceeding from clear-cut to more fuzzy boundaries and comparing segmentation between investigators. We observed that the bicipital levator ani muscle consisted of pubovisceral and puborectal portions; that the pubovisceral muscle formed, together with rectococcygeal and rectoperineal muscles, a rectal diaphragm; that the external anal sphincter consisted of its subcutaneous portion and the puborectal muscle only; that the striated urethral sphincter had three parts, of which the middle (urethral compressor) was best developed in females and the circular lower ("membranous") best in males; that the rectourethral muscle, an anterior extension of the rectal longitudinal smooth muscle, developed a fibrous node in its center (perineal body); that the perineal body was much better developed in females than males, so that the rectourethral subdivision into posterior rectoperineal and anterior deep perineal muscles was more obvious in females; that the superficial transverse perineal muscle attached to the fibrous septa of the ischioanal fat; and that the uterosacral ligaments and mesorectal fascia colocalized. To facilitate comprehension of the modified topography we provide interactive 3D-PDFs that are freely available for teaching purposes.

show abstract

Redefining the Mesentery as an Organ

Coffey

O’Leary

2021

The Mesenteric Organ in Health and Disease

View full text Add to dashboard Cite

The development of the dorsal mesentery in human embryos and fetuses

Cited by 14 publications

References 77 publications

Large intestine embryogenesis: Molecular pathways and related disorders (Review)

Large intestine embryogenesis: Molecular pathways and related disorders (Review)

Interactive three‐dimensional teaching models of the female and male pelvic floor

Redefining the Mesentery as an Organ

Contact Info

Product

Resources

About