The development of the aorta and aortic arches in rabbits

Bremer, John Lewis

doi:10.1002/aja.1000130204

Cited by 50 publications

(33 citation statements)

References 4 publications

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“…s The older concept 9 -that most blood vessels develop as buds from the aorta-has now been proved wrong. It is of interest that the arteries and veins that develop from the paired dorsal aortae, the pharyngeal branchial arches, and the cardinal veins, all closely associated in development, tend to have the same sensitivity in the adult.…”

Section: Discussionsupporting

confidence: 42%

Sensitivity of the Large Blood Vessels of the Rabbit to l -Epinephrine and l -Norepinephrine

Bevan

1961

Circulation Research

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Some of the pharmacological properties of the smooth muscle of 17 anatomically different vessels of the adult rabbit have been compared using helical strips under in vitro conditions. Using the median effective dose and the slope of the logarithm dose-probit response curve for l -epinephrine and l -norepinephrine as criteria, these vessels may be divided into two groups. The vascular muscle of the thoraeic and abdominal aorta, the femoral, main pulmonary and lobar pulmonary arteries, some preparations of the renal arteries and the inferior vena cava exhibit, within 95 per cent confidence limits, identical characteristics. They are more sensitive to l -norepinephrine than l -epinephrine, and the slopes of thc dose-response curves to these amines are the same. The muscle of the common carotid and saphena arteries and the external jugular vein is very similar to this group, but not identical. The vascular muscle of the common iliac, brachial, facial, anterior and posterior mesenteric, and celiac arteries, and the portal vein is less sensitive, and the slope of the dose-response curve more steep to these amines than the previous group. They are more sensitive to l -epinephrine than l -norepinephrnie and the slopes of the dose-response curves for these amines are not the same.

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Section: Discussionsupporting

confidence: 42%

Sensitivity of the Large Blood Vessels of the Rabbit to l -Epinephrine and l -Norepinephrine

Bevan

1961

Circulation Research

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“…It usually develops after the 6th pair is formed, does not connect the aortic sac with the dorsal aorta in a direct way and exists only for a very short phase of embryo development. In healthy individuals it vanishes without forming derivatives [Tandler, 1902;Lewis, 1906;Bremer, 1912;Moffat, 1959;Binder, 1985].…”

Section: Introductionmentioning

confidence: 47%

Some Mice Feature 5th Pharyngeal Arch Arteries and Double-Lumen Aortic Arch Malformations

Geyer

Weninger²

2012

Cells Tissues Organs

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A 5th pair of pharyngeal arch arteries (PAAs) has never been identified with certainty in mice. Murines in general are considered to not develop a 5th pair. If true, the significance of the mouse as a model for researching the genesis of malformations of the great intrathoracic arteries is limited. We aimed to investigate whether mouse embryos develop a 5th pair of PAAs and to identify malformations known to be caused by defective remodelling of the 5th PAAs. We employed the high-resolution episcopic microscopy method for creating digital volume data and three-dimensional (3D) computer models of the great intrathoracic arteries of 30 mouse embryos from days 12–12.5 post conception and 180 mouse fetuses from days 14.5 and 15.5 post conception. The 3D models of the fetuses were screened for the presence of a double-lumen aortic arch malformation. We identified such a malformation in 1 fetus. The 3D models of the embryos were analysed for the presence of 5th PAAs. Six of the 30 embryos (20%) showed a 5th PAA bilaterally, and an additional 9 (30%) showed a 5th PAA unilaterally. Our results prove that some mice do develop a 5th pair of PAAs. They also show that malformations which occur rarely in humans and result from defective remodelling of the left 5th PAA can be identified in mice as well. Thus, the mouse does represent an excellent model for researching the mechanisms driving PAA remodelling and the genesis of malformations of the great intrathoracic arteries.

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“…Although much attention has been devoted to studying the early embryological development of the vascular system (e.g., Thoma, 1911;Evans, 1909a,b;Bremer, 1912;Sabin, 1917;Chapman, 1918;Krough, 1929;Hausmann, 1935;Hiruma, 1981, 1983;Aikawa and Kawano, 19821, surprisingly few studies have dealt with the changes occurring in a vascular bed during normal postnatal growth and development of the definitive vascular pattern (e.g., Wolff et al, 1975). The rabbit ear is particularly suitable for studying development of the vasculature, as the major vessels lie in a thin sheet and can be easily viewed.…”

mentioning

confidence: 45%

Development of the vascular bed in the rabbit ear: Scanning electron microscopy of vascular corrosion casts

Morris

Bevan

1984

Am. J. Anat.

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The development of the vascular bed in the rabbit ear was investigated using vascular corrosion casts from animals of various ages. Examination of the casts revealed that the arrangement of the major auricular arteries and veins was determined before birth and was maintained during postnatal growth of the ear. Furthermore, the number of arteries branching off the central ear artery and the lateral arteries did not increase with increasing ear length. Scanning electron microscopic examination of lateral segments of adult ear casts revealed many anastomoses between marginal arteries and veins. These arteriovenous anastomoses (AVAs) occurred singly, in pairs, or in clusters of three to six. Their size and shape were variable, even in the same cast. The central segment of many AVA casts showed surface impressions of endothelial cell nuclei which were different from the impressions on adjacent arteries and veins. Arteriovenous anastomoses were also detected in ear casts from animals as young as 8 days. The density of AVAs in lateral ear segments ranged from 95-165 cm-2 in 8- to 11-day-old rabbits to 80-115 cm-2 in adults. However, estimates of the total number of AVAs in the lateral ear margin indicated that AVAs continued to be formed at a steady rate during growth of the ear. During the early neonatal period the cutaneous capillary plexuses developed prominent tufts projecting toward the skin surface, which were apparently associated with developing hair follicles. These capillary tufts were not seen in casts from fetal or adult rabbits.

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The development of the aorta and aortic arches in rabbits

Cited by 50 publications

References 4 publications

Sensitivity of the Large Blood Vessels of the Rabbit to l -Epinephrine and l -Norepinephrine

Sensitivity of the Large Blood Vessels of the Rabbit to l -Epinephrine and l -Norepinephrine

Some Mice Feature 5th Pharyngeal Arch Arteries and Double-Lumen Aortic Arch Malformations

Development of the vascular bed in the rabbit ear: Scanning electron microscopy of vascular corrosion casts

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