The development of spectrophotometric and electroanalytical methods for ascorbic acid and acetaminophen and their applications in the analysis of effervescent dosage forms

Săndulescu, Robert; Mirel, Simona; Oprean, Radu

doi:10.1016/s0731-7085(00)00277-6

Cited by 131 publications

(50 citation statements)

References 8 publications

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“…Under the specified experimental conditions, ascorbic acid undergoes oxidation resulting in the formation of dehydroascorbic acid. 29 The carbonyl group of dehydroascorbate reacts with -NH 2 group of lisinopril to form a purple coloured condensation product. By analogy to previous report, 27 the reaction is proposed to proceed as shown in Scheme 1.…”

Section: Resultsmentioning

confidence: 99%

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

Rahman¹,

Singh²,

Hoda

2005

J. Braz. Chem. Soc.

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Dois métodos espectrofotométricos, simples e sensíveis, são descritos para a determinação de lisinoprila pura e em preparações farmacêutica. O primeiro método é baseado na reação da droga com nihidrina, no solvente N, N'-dimetilformamida (DMF) a temperatura ambiente, a qual é acompanhada espectrofotometricamente pela medida do aumento da absorbância a 595 nm, em função do tempo. As técnicas de medida da velocidade inicial, da determinação da constante de velocidade e de medida em tempo fixo (10 min) foram adotadas na construção das curvas de calibração, para a determinação da concentração da droga. Os métodos de velocidade inicial e da medida em tempo fixo mostraram uma resposta linear no intervalo de concentração 10-50 μg mL -1 , enquanto o método de constante de velocidade tem resposta linear no intervalo 10-40 μg mL -1 . No segundo método, a droga reage com ácido ascórbico em solução de DMF, resultando num produto colorido com máximo de absorbância a 530 nm. A lei de Beer é obedecida no intervalo de concentração 5-50 μg mL -1 de linisoprila, com absortividade molar de 4,548×10 3 L mol -1 cm -1 . As variáveis que afetam o desenvolvimento da cor foram otimizadas, e o método foi validado estatisticamente e por estudos de recuperação. O método proposto foi usado com sucesso na determinação de lisinoprila em comprimidos comerciais.Two simple and sensitive spectrophotometric methods are described for the determination of lisinopril in pure form and pharmaceutical preparations. The first method is based on the reaction of the drug with ninhydrin in N,N'-dimethylformamide (DMF) medium at room temperature which is followed spectrophotometrically by measuring the increase in absorbance at 595 nm as a function of time. The initial-rate, rate-constant and fixed-time (at 10 minutes) procedures were used for constructing the calibration graphs to determine the concentration of the drug. The initial-rate and fixed-time procedures showed a linear response over the concentration range 10-50 μg mL -1 whereas rate-constant procedure was applicable in the range 10-40 μg mL -1 . In the second method, the drug reacts with ascorbic acid in DMF medium resulting in the formation of a coloured product, which absorbed maximally at 530 nm. Beer's law is obeyed in the concentration 5-50 μg mL -1 of lisinopril with molar absorptivity of 4.548×10 3 L mol -1 cm -1 . The variables affecting the development of the colour are optimized and the developed methods are validated statistically and through recovery studies. The proposed methods have been successfully applied to the determination of lisinopril in commercial tablets.Keyword: lisinopril, ninhydrin, ascorbic acid, dimethylformamideis an angiotensin converting enzyme (ACE) inhibitor. It is used in the treatment of hypertension and heart failure. The increasing use of this recently introduced drug, which is highly susceptible to the acidic degradation, needs simple, sensitive and selective method for the routine analysis in pharmaceutical formulations.Certain successful attempts have been...

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Section: Resultsmentioning

confidence: 99%

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

Rahman¹,

Singh²,

Hoda

2005

J. Braz. Chem. Soc.

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“…Acetaminophen/paracetamol (ACOP) is an active ingredient of several pharmaceutical products, widely used as an analgesic [1]. Acetaminophen overdose is a frequent cause of fulminating hepatic failure in Europe and the USA [2].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Synthesis of Titanium Nano Particles at Carbon Paste Electrodes and Its Applications as an Electrochemical Sensor for the Determination of Acetaminophen in Paracetamol Tablets

Gururaj¹,

Swamy²

2013

SNL

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Titania nano particles were synthesized at carbon paste electrode by cyclic voltammetry and then it was employed for the determination of acetaminophen in phosphate buffer at pH 7.4. Carbon paste electrode with titania nano particle displayed excellent electrochemically catalytic activities by shifting the oxidation potential of acetaminophen towards the negative side. The mass transfer process at electrochemical interface was diffusion controlled. Electrochemical techniques such as, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization methods were used to measure the resistance of the electrodes. The resistance of the titanium electrode decreased in two orders when compared to the bare carbon paste electrode; the decrease in the resistance of the electrode and increase in the surface area of the electrode are responsible for the negative shifting of the oxidation potential of acetaminophen. The present method was applied to the determination of actetaminophen in paracetamol tablet, urine and blood sample by using standard addition method and the obtained results were satisfactory with a good recovery of 98%.

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“…Most electrochemical methods rely on the use of modified carbon based electrodes such as cobalt hexacyanoferrate modified graphite was composite electrodes [3], single-wall carbon nanotube-dicetyl phosphate film modified glassy carbon electrodes [13], polyaniline-multiwalled carbon nanotubes composite modified electrodes [14], carbon film resistor electrodes [15], C 60 -modified glassy carbon electrodes [16], L-cysteine modified glassy carbon electrodes [17], carbon nanotubes based nanoelectrode arrays [18], boron-doped diamond thin film electrodes [19], pumice mixed carbon paste electrodes [20] and metalloporphyrin modified glassy carbon electrodes. However, carbon nanotube modified electrodes have been used for detection of a variety of analytical and biological targets [20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Studies and Square Wave Voltammetry of Paracetamol at Managanese Modified Carbon Paste Electrode

S¹,

Najih²,

Valery³

et al. 2013

Pharmaceut Anal Acta

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The development of spectrophotometric and electroanalytical methods for ascorbic acid and acetaminophen and their applications in the analysis of effervescent dosage forms

Cited by 131 publications

References 8 publications

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

Electrochemical Synthesis of Titanium Nano Particles at Carbon Paste Electrodes and Its Applications as an Electrochemical Sensor for the Determination of Acetaminophen in Paracetamol Tablets

Electrochemical Studies and Square Wave Voltammetry of Paracetamol at Managanese Modified Carbon Paste Electrode

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