The development of skin barrier function in the neonate

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics

“…A further series of experiments, the results of which are presented in Figures 5 and 6 and Table 2, aimed to examine whether iontophoresis might provide a safe and effective approach to deliver midazolam to paediatric patients and, in particular, to premature neonates, the skin barrier function of whom represents a "moving target" after birth [16][17][18][19][20][21][22][23][24]. To experimentally model completely and partially compromised skin barriers, the stratum corneum (SC) was progressively removed by adhesive tape-stripping and the extent of perturbation was quantified using measurements of transepidermal water loss (TEWL).…”

“…The neonatal skin barrier function is close to that of adults by ~35 weeks of gestation [15]. However, for very premature infants (i.e., less than 34 weeks gestation), the stratum corneum is incompletely formed and barrier function is noticeably impaired [16,17] as shown clearly by measurements of the rate of transepidermal water loss (TEWL) [18][19][20][21]. A lower barrier function is shown by elevated TEWL.…”

Richard Guy and His Collaborators: ‘Crackling' the Skin Code

“…However, the picture would not be complete without mentioning his work on the skin barrier function including that of premature neonates [19,30,104,126,127] and the recent work on the effect of aqueous cream BP on human SC [128]. Other highly cited work includes that on plasma membrane poration by Mehier-Humbert et al [10], on micro-emulsions [8] and on sonophoresis [12,17].…”