The Development of Organic Iodine Compounds as X-ray Contrast Media

Comparative radiopacity of bone graft materials

“…Poor quality X-ray images of the low density HA material poses a practical problem with respect to immediate and short term postoperative monitoring of bone formation by the clinicians (Ajeesh et al, 2010). Therefore, organic contrast agents like organo bismuth compounds (Deb et al, 2002) and organo iodine compounds (Wallingford, 1953) were added to calcium phosphate bone fillers in order to confer radiopacity and thus aid in the radiographic assessment of the implants in vivo. Ajeesh et al (2010), used sintered nano iron oxide-HA composite ceramics to increase the radiopacity of the HA graft material.…”

Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents

“…To better delineate soft tissue regions the X-ray contrast agents based on heavy elements such as a silver, bismuth, barium, iodine, etc. were used [2,3]. To date, iodinated X-ray contrast media based on 1,3,5-triiodobenzene core are among the mostly utilized pharmaceuticals for intravascular administration.…”

The Utility of DiceCT Imaging for High-Throughput Comparative Neuroanatomical Studies

“…Although excellent at visualizing mineralized vertebrate tissues such as bone, dentin, and enamel, X-ray technologies are comparatively poor at differentiating relatively low-density soft-tissue structures, such as the central and peripheral nervous systems. To overcome this obstacle, diceCT utilizes iodine in the form of aqueous iodine-potassium iodide (a.k.a., Lugol's iodine solution, strong iodine solution, or simply I 2 KI) or alcoholic iodine (I 2 E and I 2 M, using ethanol and methanol, respectively, as solvents [Metscher 2009a[Metscher , 2009b[Metscher , 2013) as a radiopaque contrast agent [Wallingford, 1953].…”