The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

Shen, Chieh-Yu; Lu, Cheng‐Hsun; Wu, Cheng-Han; Li, Ko-Jen; Kuo, Yu-Min; Hsieh, Song-Chou; Yu, Chia‐Li

doi:10.3390/molecules25235591

Cited by 151 publications

(114 citation statements)

References 159 publications

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“…MRPs lead to the formation of advanced-glycation (AGEs) and lipoxidation end products (ALEs) with proinflammatory activity. Moreover, MRPs could activate inflammatory responses via macrophages activation and immune dysfunction in helper T lymphocytes [ 55 ]. Therefore, all these studies could explain the loss of anti-inflammatory effects observed for HT30.…”

Section: Resultsmentioning

confidence: 99%

A Novel Strategy to Produce a Soluble and Bioactive Wheat Bran Ingredient Rich in Ferulic Acid

et al. 2021

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Wheat bran (WB) is a byproduct from the milling industry that contains bioactive compounds beneficial to human health. The aim of this work was on the one hand, increasing extractability of antioxidant and anti-inflammatory compounds (specifically ferulic acid, FA), through enzymatic hydrolysis combined with hydrothermal treatment (HT) and high hydrostatic pressure (HHP). On the other hand, enhancing the stability of final ingredient applying spray-drying (SPD) and microencapsulation (MEC). The use of HT increased FA, total phenolics (TP), and antioxidant capacity (AC) in WB hydrolysates, regardless the HT duration. However, the HT tested (30 min, HT30) produced a loss in anti-inflammatory activity (AIA). The combination of HT (15 min, HT15) with HHP increased AIA of the WB. SPD enhanced the TP yield in WB with no significant effect of inlet temperature (up to 140 °C) on phenolic profile mainly composed of trans-FA and smaller amounts of cis-FA and apigenin diglucosides. SPD caused a temperature-dependent increase in AC (160 °C > 140 °C > 130 °C). SPD inlet temperatures affected total solids yield (from 22 to 36%), with the highest values at 140 °C. The use of HHP in combination with HT resulted in >2-fold increase in total solids yield.

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Section: Resultsmentioning

confidence: 99%

A Novel Strategy to Produce a Soluble and Bioactive Wheat Bran Ingredient Rich in Ferulic Acid

et al. 2021

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“…AGEs refer to a kind of glycosylated molecules produced by oxidative stress or metabolism, which include not only cytokines but also some metabolites. After RAGE recognizes and binds to the corresponding ligand, it can activate the NF-κB pathway, thereby promoting the secretion of cytokines by inflammatory cells, such as IL-6 and TNF-α ( Shen et al, 2020 ). By the way, the activation of RAGE and NFκB also send a message to reactive oxidant species (ROS), a key role in oxidative stress, by NADPH oxidase ( Daffu et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Single-Cell RNA Sequencing Revealed CD14+ Monocytes Increased in Patients With Takayasu’s Arteritis Requiring Surgical Management

Gao

Wu²,

Yu³

et al. 2021

Front. Cell Dev. Biol.

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Objectives: Takayasu Arteritis (TA) is a highly specific vascular inflammation and poses threat to patients’ health. Although some patients have accepted medical treatment, their culprit lesions require surgical management (TARSM). This study aimed at dissecting the transcriptomes of peripheral blood mononuclear cells (PBMCs) in these patients and to explore potential clinical markers for TA development and progression.Methods: Peripheral blood were collected from four TA patients requiring surgical management and four age-sex matched healthy donors. Single cell RNA sequencing (scRNA-seq) was adopted to explore the transcriptomic diversity and function of their PBMCs. ELISA, qPCR, and FACS were conducted to validate the results of the analysis.Results: A total of 29918 qualified cells were included for downstream analysis. Nine major cell types were confirmed, including CD14+ monocytes, CD8+ T cells, NK cells, CD4+ T cells, B cells, CD16+ monocytes, megakaryocytes, dendritic cells and plasmacytoid dendritic cells. CD14+ monocytes (50.0 vs. 39.3%, p < 0.05) increased in TA patients, as validated by FACS results. TXNIP, AREG, THBS1, and CD163 increased in TA patients. ILs like IL-6, IL-6STP1, IL-6ST, IL-15, and IL-15RA increased in TA group.Conclusion: Transcriptome heterogeneities of PBMCs in TA patients requiring surgical management were revealed in the present study. In the patients with TA, CD14+ monocytes and gene expressions involved in oxidative stress were increased, indicating a new treatment and research direction in this field.

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“…Eventually, these intermediate products may be further polymerized or reacted with amino acids and nucleic acids to form a variety of compounds collectively termed as advanced glycated end-products (AGEs). 3,29 The glycation process is shown in Figure 3. To date, many AGEs-modified proteins, such as hemoglobin, albumin, collagen, lens proteins,and erythrocyte membrane proteins, have been reported.…”

Section: Non-enzymatic Glycated Modification Of Tf and Related Diseasesmentioning

confidence: 99%

“…These pathways act in synergy on the nuclear factor NF-κB to induce the production and release of proinflammatory cytokines (TNF-α and IL-6), oxidative stress indicators (ROS), and pro-fibrotic cytokines (TGF-β and IL-13), thereby promoting the occurrence and development of diabetes and its complications. 29,54,58,59 Carboxymethyl lysine (CML) is one of the members of the AGEs family, which might interfere with the regulatory feedback mechanism of intracellular cholesterol to cause intracellular lipid accumulation and diabetic nephropathy, and AGEs inhibitor aminoguanidine hydrochloride may delay the progress of diabetic nephropathy. 60 Furthermore, AEGs overload is related to the occurrence of diabetic nephropathy, probably by interfering with the autophagy-lysosomal pathway.…”

Section: Molecular Mechanisms Of Non-enzymatic Glycated Tf In Diabetes and Diabetic Complicationsmentioning

confidence: 99%

Non-Enzymatic Glycation of Transferrin and Diabetes Mellitus

Ma¹,

Cai²,

Wang³

et al. 2021

DMSO

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Diabetes is a metabolic disease characterized by high blood sugar. Its complications may damage multiple organs, such as eyes, kidneys, heart, blood vessels, and nerves, severely threatening human health. Transferrin (Tf) is a major iron transport protein in the body. Recent studies have shown that the degree of non-enzymatic glycated modification of Tf is increased in diabetic patients, and glycated Tf is closely related to the occurrence and development of diabetes and diabetic complications. However, the molecular mechanisms underlying this glycated modification in diabetes and diabetic complications are still unclear. It is speculated that the mechanism may be that glycated modification reduces the binding ability of Tf and its receptor TfR, followed by excessive iron accumulation in the body. Iron overload in the body may further lead to the death of pancreatic beta cells and insulin resistance by increasing oxidative stress, inducing iron death, interfering with the insulin signaling pathway, and causing autophagy deficiency. In addition, non-enzymatic glycation affects the binding of Tf with chromium and reduces the ability of Tf to transport chromium into tissues, resulting in a decrease in the levels of chromium in tissues and ultimately affecting the sensitivity of tissues to insulin. In diabetic patients, the concentrations of glycated Tf in serum were significantly correlated with those of fructosamine.Tf has a shorter half-life, and not affected by anemia or hypoalbuminemia and less negative charge under physiological conditions, while glycated modification could not change the isoelectric point of Tf, which easily passes through the negatively charged basement membrane of the glomerulus. Therefore, compared to glucosamine, HbA1C, etc., glycated Tf may be a future biomarker for evaluating short-term glycemic control and early renal damage in diabetic patients.

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The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

Cited by 151 publications

References 159 publications

A Novel Strategy to Produce a Soluble and Bioactive Wheat Bran Ingredient Rich in Ferulic Acid

A Novel Strategy to Produce a Soluble and Bioactive Wheat Bran Ingredient Rich in Ferulic Acid

Single-Cell RNA Sequencing Revealed CD14+ Monocytes Increased in Patients With Takayasu’s Arteritis Requiring Surgical Management

Non-Enzymatic Glycation of Transferrin and Diabetes Mellitus

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