The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration

Lin, Yi-Ting; Shie, Ming‐You; Lin, Yu‐Hung; Ho, Chao-Ching; Kao, Chia‐Tze; Huang, Tsui‐Hsien

doi:10.3390/polym13183107

Cited by 2 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our data suggest that higher C3S content may not directly translate into higher DTS as this property is also governed by the presence and reactions of other components like dicalcium silicate and aluminates, currently present as major or minor phases in commercial products (Primus et al 2019). Hence, further research shall unveil the effects arising from the interaction of these components on cement’s properties (Lin, Shie, et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics

Cahyanto,

Rath,

Teo

et al. 2023

J Dent Res

View full text Add to dashboard Cite

Calcium silicate (C3S) cements are available in kits that do not account for patients’ specific needs or clinicians’ preferences regarding setting time, radiopacity, mechanical, and handling properties. Moreover, slight variations in powder components and liquid content affect cement’s properties and bioactivity. Unfortunately, it is virtually impossible to optimize several cement properties simultaneously via the traditional “one variable at a time” strategy, as inputs often induce trade-offs in properties (e.g., a higher water-to-powder ratio [W/P] increases flowability but decreases mechanical properties). Herein, we used Taguchi’s methods and genetic algorithms (GAs) to simultaneously analyze the effect of multiple inputs (e.g., powder composition, radiopacifier concentration, and W/P) on setting time, pH, flowability, diametral tensile strength, and radiopacity, as well as prescribe recipes to produce cements with predicted properties. The properties of cements designed with GAs were experimentally tested, and the results matched the predictions. Finally, we show that the cements increased the genetic expression of odonto/osteogenic genes, alkaline phosphatase activity, and mineralization potential of dental pulp stem cells. Hence, GAs can produce cements with tailor-made properties and differentiation potential for personalized endodontic treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics

Cahyanto,

Rath,

Teo

et al. 2023

J Dent Res

View full text Add to dashboard Cite

show abstract

“…Our previous results showed that inclusion of calcium silicate (CS) products into GelMa were able to enhance angiogenesis via increasing the secretion of VEGF from fibroblasts [20]. In fact, CS is the bioceramic that is always used as an endodontics material for root repair [21]. This was due to the sustained and gradual release of silicate (Si) and calcium (Ca) ions into the surrounding fluid upon degradation and immersion [22].…”

Section: Introductionmentioning

confidence: 99%

Synergies of Human Umbilical Vein Endothelial Cell-Laden Calcium Silicate-Activated Gelatin Methacrylate for Accelerating 3D Human Dental Pulp Stem Cell Differentiation for Endodontic Regeneration

et al. 2021

Self Cite

View full text Add to dashboard Cite

According to the Centers for Disease Control and Prevention, tooth caries is a common problem affecting 9 out of every 10 adults worldwide. Dentin regeneration has since become one of the pressing issues in dentistry with tissue engineering emerging as a potential solution for enhancing dentin regeneration. In this study, we fabricated cell blocks with human dental pulp stem cells (hDPSCs)-laden alginate/fish gelatin hydrogels (Alg/FGel) at the center of the cell block and human umbilical vascular endothelial cells (HUVEC)-laden Si ion-infused fish gelatin methacrylate (FGelMa) at the periphery of the cell block. 1H NMR and FTIR results showed the successful fabrication of Alg/FGel and FGelMa. In addition, Si ions in the FGelMa were noted to be bonded via covalent bonds and the increased number of covalent bonds led to an increase in mechanical properties and improved degradation of FGelMa. The Si-containing FGelMa was able to release Si ions, which subsequently significantly not only enhanced the expressions of angiogenic-related protein, but also secreted some cytokines to regulate odontogenesis. Further immunofluorescence results indicated that the cell blocks allowed interactions between the HUVEC and hDPSCs, and taken together, were able to enhance odontogenic-related markers’ expression, such as alkaline phosphatase (ALP), dentin matrix phosphoprotein-1 (DMP-1), and osteocalcin (OC). Subsequent Alizarin Red S stain confirmed the benefits of our cell block and demonstrated that such a novel combination and modification of biomaterials can serve as a platform for future clinical applications and use in dentin regeneration.

show abstract

The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration

Cited by 2 publications

References 51 publications

Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics

Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics

Synergies of Human Umbilical Vein Endothelial Cell-Laden Calcium Silicate-Activated Gelatin Methacrylate for Accelerating 3D Human Dental Pulp Stem Cell Differentiation for Endodontic Regeneration

Contact Info

Product

Resources

About