The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication

Cisnetto, Valentina; Barlow, James

doi:10.1016/j.respol.2019.103917

Cited by 17 publications

(12 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As with the technology development process, the engagement strategy is also a phased approach that builds on existing guidance and knowledge and aims at co-developing a constructive dialogue with communities and other stakeholders to foster their participation in the technology development. Each phase helps clarify values, dynamics, and factors for Target Malaria to integrate in the development of an innovative vector control tool [24]. The outcomes will strengthen the following stages of the research and adapt the stakeholder engagement model and content.…”

Section: Introductionmentioning

confidence: 94%

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Toé

Barry

et al. 2021

Malar J

View full text Add to dashboard Cite

Background Innovative tools are needed to complement the existing approach for malaria elimination. Gene drive mosquitoes are one potential new technology in the control of malaria vectors. Target Malaria is one of the research projects developing this technology, and in July 2019, the project proceeded to an important step for this evaluation pathway: the small-scale release of non-gene drive sterile male mosquitoes in a village in Burkina Faso. In addition to the entomological and laboratory work to prepare for this important milestone, significant community and stakeholder engagement work was done. The existing guidelines on gene drive mosquito provide an overall framework for such engagement work. However, they do not provide a road map on how to proceed or what benchmarks should be used to assess this work. Methods This study provides a review of engagement activities relevant to field trials on non-gene drive genetically-modified mosquitoes as well as an assessment framework—using both qualitative and quantitative studies as well as an audit procedure. The latter was implemented to evaluate whether the release activities could proceed with the appropriate level of agreement from the community. Results This paper shows the importance of this first phase of work to innovate and learn about engagement processes for responsible research in the field of genetic approaches for malaria vector control. The function of these assessments is crucial for the learning agenda. The assessments demonstrated ways to increase understanding and ensure effective progress with field studies and, therefore, the pathway for responsible research. Conclusion Gene drive technology is increasingly considered as a promising approach to control vector borne diseases, in particular malaria. Stakeholders’ involvement in this research process is one of the recurring requirements in international guidance documents. With this paper Target Malaria offers an opportunity to explore the practical achievements and challenges of stakeholder engagement during early phases of a technology evaluation, and in particular how it implemented an assessment framework to learn from its experience.

show abstract

Section: Introductionmentioning

confidence: 94%

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Toé

Barry

et al. 2021

Malar J

View full text Add to dashboard Cite

show abstract

“…Discussions of social and organizational innovation often include the concept of serendipity ( Cisnetto and Barlow, 2020 ; Leckel et al, 2020 ; Sauer and Bonelli, 2020 ; Fink et al, 2017 ; Heger and Rohrbeck, 2012 ; Anokhin et al, 2011 ; Kakko and Inkinen, 2009 ; Knoben et al, 2006 ; Koh, 2000 ; Godoe, 2000 ). It is also a feature of the process of research ( Muruyama et al, 2015 ; McKelvey et al, 2015 ; Cunha et al, 2012 ; Boudreau et al, 2011 ; Buenstorf, 2009 ; Rahmandad, 2008 ; Graebner, 2004 ; Nelson, 2003 ).…”

Section: Literature Reviewmentioning

confidence: 99%

Innovation in crisis: The role of ‘exaptive relations’ for medical device development in response to COVID-19

James

Liu

Stephens

et al. 2022

Technological Forecasting and Social Change

View full text Add to dashboard Cite

“…HCB, 2017;Rabitz, 2019;Brooks, 2020); 10) Developing pathways/recommendations to/for responsible and sustainable deployment of the technology (e.g. Oye et al, 2014;WHO, 2014;Akbari et al, 2015;NASEM, 2016;Adelman et al, 2017a,b;Emerson et al, 2017;Esvelt and Gemmell, 2017;Lunshof and Birnbaum, 2017;Baltzegar et al, 2018;James et al, 2018;Thompson, 2018;Backus and Delborne, 2019;Bartumeus et al, 2019;Kuzma, 2019;Cisnetto and Barlow, 2020;Warmbrod et al, 2020); 11) Assessing the desirability and ethics of engineered gene drives (Pugh, 2016;Thompson, 2018;Jones et al, 2019;Thomas et al, 2019;ECNH, 2019;Sandler, 2020;WHO, 2020); 12) Developing guidance/best practices on societal/stakeholder engagement and communication (e.g. Bartumeus et al, 2019;Brossard et al, 2019;Buchthal et al, 2019;George et al, 2019;Hartley et al, 2019;Schairer et al, 2019;Singh, 2019;Thizy et al, 2019;MacDonald et al, 2020;Palmer et al, 2020;Serr et al, 2020); 13) Developing effective management and implementation of disease vector control programmes (e.g.…”

Section: State Of the Artmentioning

confidence: 99%

Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post‐market environmental monitoring of genetically modified insects containing engineered gene drives

Naegeli¹,

Bresson²,

Dalmay³

et al. 2020

EFS2

View full text Add to dashboard Cite

Advances in molecular and synthetic biology are enabling the engineering of gene drives in insects for disease vector/pest control. Engineered gene drives (that bias their own inheritance) can be designed either to suppress interbreeding target populations or modify them with a new genotype. Depending on the engineered gene drive system, theoretically, a genetic modification of interest could spread through target populations and persist indefinitely, or be restricted in its spread or persistence. While research on engineered gene drives and their applications in insects is advancing at a fast pace, it will take several years for technological developments to move to practical applications for deliberate release into the environment. Some gene drive modified insects (GDMIs) have been tested experimentally in the laboratory, but none has been assessed in small-scale confined field trials or in open release trials as yet. There is concern that the deliberate release of GDMIs in the environment may have possible irreversible and unintended consequences. As a proactive measure, the European Food Safety Authority (EFSA) has been requested by the European Commission to review whether its previously published guidelines for the risk assessment of genetically modified animals (EFSA, 2012 and 2013), including insects (GMIs), are adequate and sufficient for GDMIs, primarily disease vectors, agricultural pests and invasive species, for deliberate release into the environment. Under this mandate, EFSA was not requested to develop risk assessment guidelines for GDMIs. In this Scientific Opinion, the Panel on Genetically Modified Organisms (GMO) concludes that EFSA's guidelines are adequate, but insufficient for the molecular characterisation (MC), environmental risk assessment (ERA) and post-market environmental monitoring (PMEM) of GDMIs. While the MC, ERA and PMEM of GDMIs can build on the existing risk assessment framework for GMIs that do not contain engineered gene drives, there are specific areas where further guidance is needed for GDMIs.

show abstract

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication

Cited by 17 publications

References 118 publications

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Innovation in crisis: The role of ‘exaptive relations’ for medical device development in response to COVID-19

Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post‐market environmental monitoring of genetically modified insects containing engineered gene drives

Contact Info

Product

Resources

About