The Development of Bone

Watt, James Crawford

doi:10.1001/archsurg.1928.01140120121005

Cited by 29 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have been reported [49, 50, 53-56, 58, 59]. Bone cells are reported to "dump" or form "Ca complexes" adjacent to their surfaces [49,57,60,61]. Vesicles have been implicated in various aspects of bone and cartilage mineralization [ 14,[62][63][64].…”

Section: Discussionmentioning

confidence: 99%

Blood:Bone disequilibrium. VI. Studies of the solubility characteristics of brushite: Apatite mixtures and their stabilization by noncollagenous proteins of bone

Neuman

Diamond

et al. 1982

Calcif Tissue Int

View full text Add to dashboard Cite

Recent evidence of the occurrence of brushite in newly formed bone mineral prompted a study of the solubility properties of brushite:apatite mixtures under physiological conditions and the influence on them of pH, lactate, pyruvate, and, particularly, noncollagenous bone proteins (NCBPs). Brushite alone was surprisingly stable in solution at pH 7.4, 37 degrees C. In the presence of increasing amounts of apatite, hydrolysis of brushite to an insoluble phase occurred. A decrease of 0.1 pH unit or the addition of 1.5 mM pyruvate or 10 mM lactate increased the ion activity product (Ca2+ x HPO4(2-) 3 or more times. However, within the loose envelope of bone such conditions so different from those in the circulation might be only local or temporary. NCBPs, on the other hand, stabilized brushite in solution alone as well as in the presence of apatite for days. They probably act by adsorbing strongly to the crystal surface and preventing nucleation by apatite. This brushite-apatite-bone protein system exhibits solubility characteristics that can resolve the old problems presented by the participation of the skeleton in extracellular calcium homeostasis on the one hand, and by the apparent insolubility of the apatite mineral of bone on the other.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood:Bone disequilibrium. VI. Studies of the solubility characteristics of brushite: Apatite mixtures and their stabilization by noncollagenous proteins of bone

Neuman

Diamond

et al. 1982

Calcif Tissue Int

View full text Add to dashboard Cite

show abstract

“…Enchondral ossification is similarly described by most writers, and the course is the same in the diaphyses and epiphyses of the long bones as in the short bones. ))The ossification of the epiphyses of the long bones develops in all respects as though i t were an independent bone, and the process is exactly similar to that found in the short, irregular bones such as the tarsals and carpals)) (WATT 1928). Ossification is preceded by typical structural changes in the centre of the cartilaginous epiphysis.…”

Section: Vascularimtion and Ossification Of The Epiphysesmentioning

confidence: 60%

The Reaction to Mechanical Trauma in Growing Articular Cartilage: An Experimental Study on Rabbits and a Comparison of the Results with the Pathological Anatomy of Osteochondritis Dissecans

Tallqvist¹

1962

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

Bone growth studies—a miniature bone fracture observed microscopically in a transparent chamber introduced into the rabbit's ear

Kirby‐Smith

1933

Am. J. Anat.

View full text Add to dashboard Cite

There has been much work done on the subject of the growth and absorption of bone but there are still many problems connected with this field which remain unsettled. As most of the information has been obtained from the study of sections from dead material which has been fixed, cut, and stained, it was thought that observations on living bone might add to our knowledge of the processes connected with bone growth and absorption.With this end in view, studies were begun in the spring of 1927 upon the developing limbs of living amphibian larvae.Considerable progress was made with this object, but it was abandoned for a more promising method. Sandison ( '28 b), using the method of inserting transparent chambers in rabbits' ears, developed in this laboratory under the direction of Dr. E. R. Clark (Sandison, '28 a ; Clark, Kirby-Smith, Rex, and Williams, '30), demonstrated that bone transplanted at the time of installation of such chambers could be grown and observed microscopically in the living mammal. It was then decided to continue the study of bone growth in the living animal by means of various modifications of the transparent chamber method.The work in this laboratory on the development of the method for studying cells and tissues in transparent chambers inserted in the rabbit's ear is being aided by a 5-year grant from the Rockefeller Foundation. 377

show abstract

The Development of Bone

Cited by 29 publications

References 29 publications

Blood:Bone disequilibrium. VI. Studies of the solubility characteristics of brushite: Apatite mixtures and their stabilization by noncollagenous proteins of bone

Blood:Bone disequilibrium. VI. Studies of the solubility characteristics of brushite: Apatite mixtures and their stabilization by noncollagenous proteins of bone

The Reaction to Mechanical Trauma in Growing Articular Cartilage: An Experimental Study on Rabbits and a Comparison of the Results with the Pathological Anatomy of Osteochondritis Dissecans

Bone growth studies—a miniature bone fracture observed microscopically in a transparent chamber introduced into the rabbit's ear

Contact Info

Product

Resources

About