The Development of Analytical Method for the Determination of Azelaic Acid Content in Cosmetic Cream Products

Lusianti, Erita; Wibowo, Rahmat; Hudiyono, Sumi

doi:10.1088/1757-899x/299/1/012011

Cited by 4 publications

(7 citation statements)

References 4 publications

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“…Considering that there are two carboxyl groups of azelaic acid, the ester derivative is more stable and easier to detect. 27 It is thus feasible to use an esterification reagent or an acylation reagent to convert carboxyl group to ester. Because of the presence of a water phase in cosmetics, boron trifluoride-ethyl ether complex was not suitable as an acylation reagent.…”

Section: Resultsmentioning

confidence: 99%

“… 26 Some studies demonstrated that the methyl derivatives were more popular because of its well-established literature procedures, inexpensiveness, and lower toxicity than others. 27 GC with the derivatization of fatty acids to methyl esters was used to determine the amount of azelaic acid in the oil paintings of old Flemish master painters, 28 the composition of Medieval and Renaissance Florentine paintings that originally contained azelaic acid, 29 and the content of azelaic acid in air 30 , 31 and in tobacco leaves. 32 Lusianti et al developed a method to analyze azelaic acid in self-made cosmetics derivatized through 4 mL of BF 3 -methanol 10% at 60 °C for 10 min.…”

Section: Introductionmentioning

confidence: 99%

“… 32 Lusianti et al developed a method to analyze azelaic acid in self-made cosmetics derivatized through 4 mL of BF 3 -methanol 10% at 60 °C for 10 min. 27 Garelnabi et al determined azelaic acids in a biological sample by GC, LCMS, and GCMS. Additionally, in GC analysis, 1 mL of 14% BF 3 -methanol was used for the methylesterfication.…”

Section: Introductionmentioning

confidence: 99%

“…Pusvaskiene et al evaluated the content of azelaic acid in the natural aquatic environment by GC method using the ethylchloroformate as a reagent for derivatization . Some studies demonstrated that the methyl derivatives were more popular because of its well-established literature procedures, inexpensiveness, and lower toxicity than others . GC with the derivatization of fatty acids to methyl esters was used to determine the amount of azelaic acid in the oil paintings of old Flemish master painters, the composition of Medieval and Renaissance Florentine paintings that originally contained azelaic acid, and the content of azelaic acid in air , and in tobacco leaves .…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Experimental Procedure for Determining Azelaic Acid in Cosmetics by Gas Chromatography Derivatized through Ethanol

et al. 2022

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The quantitative evaluation of azelaic acid is becoming critical in the development of new medicinal products and in environment. A feasible method for the determination of azelaic acid in cosmetics by gas chromatographic-mass spectrometer detector (GC-MS) with derivation was developed and optimized. The derivative effect was good, when azelaic acid was derivatized through ethanol at room temperature for 10 min with 800 μL of sulfuric acid as a catalyst. A good linear relationship of azelaic acid derivative was present from 10 to 1000 mg L –1 ( R 2 = 0.9997). Detection limit and quantitative limit of GC was 15 and 50 mg kg –1 , respectively. The recovery rate was in the range from 87.7% to 101% with all relative standard deviation (RSD) values less than 4%, denoting the method meeting the requirement of the analysis. Therefore, this method has the advantages of strong anti-interference ability and accurate results. Among the eight samples nominally azelaic acid, only three were detected. The respective content was 78 133, 16 710, and 2431 mg kg –1 . The results showed that the actual addition of the azelaic acid in the market was quite different with label identification, being worthy of further attention. Further, it also provided a favorable experience for the monitoring of azelaic acid in the environment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of Experimental Procedure for Determining Azelaic Acid in Cosmetics by Gas Chromatography Derivatized through Ethanol

et al. 2022

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“…Dimethyl azelate may results an esterification reaction between azelaic acid (1,7‐heptane‐dicarboxylic acid) saturated dicarboxylic acid, which is naturally present in rice grains, milk and castor oil, 38 with methanol (alcohol).…”

Section: Resultsmentioning

confidence: 99%

Potent odorants and sensory characteristics of the soft white cheese “Jben”: Effect of salt content

Sarhir

Amanpour

Bouseta

et al. 2022

Flavour & Fragrance J

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Jben is a highly popular soft white cheese consumed in Morocco for its nutritional and health benefits. The aroma and aroma‐active compounds of salted and unsalted Jben were investigated in this study. Aroma compounds were isolated by the purge and trap extraction (PTE) method and analysed by aroma extract dilution analysis (AEDA) and gas chromatography–mass spectrometry‐olfactometry (GC–MS‐O). A total of 36 aroma compounds were characterized Jben samples, among them 30 and 32 compounds were detected in the salted Jben (260.88 mg/kg) and unsalted Jben (230.04 mg/kg) samples respectively. The alcohols, followed by acids and esters, were the most dominant aroma compounds in both samples. A total of 22 (salted Jben) and 25 (unsalted Jben) aroma‐active compounds were detected in the samples using GC–MS‐O. Based on the flavour dilution (FD) factor, the most potent aroma‐active compounds were ethyl caproate (FD = 2048, OAV = 2306, overripe fruit and pineapple odours), isoamyl acetate (FD = 2048, OAV = 2491, apple odour), hexyl acetate (FD = 1024, OAV = 1355, green odour), and isoamyl butyrate (FD = 1024, OAV = 932, green‐fruity odour) for the salted Jben sample and ethyl caproate (FD = 2048, OAV = 2388) and isoamyl acetate (FD = 1024, OAV = 880) for the unsalted Jben sample. The odour activity values (OAVs) ranged from 1 to 2491. The lowest OAVs represent the low aromatic active compounds (FD ≤ 32). The GC–MS‐O results were also consistent with the results of sensory analysis of the Jben samples.

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An innovative spectrofluorimetric approach for determination of azelaic acid in bulk and pharmaceutical formulation through derivatization with 9-chloromethylanthracene

Hamid

Mabrouk

Hammad

et al. 2022

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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The Development of Analytical Method for the Determination of Azelaic Acid Content in Cosmetic Cream Products

Cited by 4 publications

References 4 publications

Optimization of Experimental Procedure for Determining Azelaic Acid in Cosmetics by Gas Chromatography Derivatized through Ethanol

Optimization of Experimental Procedure for Determining Azelaic Acid in Cosmetics by Gas Chromatography Derivatized through Ethanol

Potent odorants and sensory characteristics of the soft white cheese “Jben”: Effect of salt content

An innovative spectrofluorimetric approach for determination of azelaic acid in bulk and pharmaceutical formulation through derivatization with 9-chloromethylanthracene

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