The development of adenylate kinase in rat liver

Hommes, F. A.; Richters, André; Beere, A.

doi:10.1016/0304-4165(71)90219-4

Cited by 5 publications

(1 citation statement)

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“…This behaviour is different to that of the liver enzymes. Hommes et al [30] have described the developmental patterns of these isoenzymes in liver and have found that both activities sharply rise from birth to 10 days after birth and later remain un changed. Mitochondrial adenylate kinase is four times higher in liver than in brain, whereas the brain cytoplasmic enzyme is double the liver level.…”

Section: Adenylate Kinasementioning

confidence: 99%

Development of Enzymes of Adenine Nucleotide Metabolism in Rat Brain and Liver

Andrés¹,

Machado²

1982

Neonatology

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The developmental changes in the activity of certain representative enzymes of adenine nucleotide metabolism, namely AMP deaminase, adenylate kinase and creatine kinase, have been studied in rat brain and liver. The principal points observed can be summarised as follows. (1) Fetal liver has a remarkably high AMP deaminase activity, which decreases immediately after birth. (2) The activities of both soluble and mitochondrial forms of brain creatine kinase are about 50-fold those of liver. The activities of these liver enzymes remain unchanged during the developmental period. In brain, however, these enzymes increase their activities about 3 and 5 times in the cytoplasmic and mitochondrial fractions, respectively. (3) The brain adenylate kinase activity from cytoplasmic fractions increased 4-fold during the 10- to 30-day period, whereas the enzyme from mitochondrial fractions remained unchanged.

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Section: Adenylate Kinasementioning

confidence: 99%