The development of adenyl cyclase in rat liver, kidney, brain and skeletal muscle

Evidence for Delayed Development of the Glucagon Receptor of Adenylate Cyclase in the Fetal and Neonatal Rat Heart

“…Augmentation of fetal hepatic adenylate cyclase by epinephrine and glucagon has been observed previously by other investigators (17,18). Previously it has been suggested that epinephrine and glucagon activate a single myocardial adenylate cyclase enzyme by interacting with separate receptors (4-6).…”

“…These effects appear to be secondary to the stimulation of adenylate cyclase with the consequent increase in intracellular concentration of cyclic adenosine 3',5'-monophosphate (cyThis paper was presented in part before the Annual National Meeting of the American Federation for Clinical Research, Atlantic City, N. J. 30 April 1972. Received for publication 17 May 1972 and in revised form 1 August 1972. clic AMP). Evidence supporting the role of cyclic AMP in the action of these hormones has recently been reviewed (4).…”

Patterns of Development of Adenyl Cyclase Activity and Norepinephrine Responsiveness in the Rat

“…Some of these are: (1) microscopic appearance of the cerebral cortex, which very nearly achieves its adult form between the 12th and 15th postnatal day [4]; (2) total DNA content of the cerebrum, which rises rapidly between the 7th and the 15th days and peaks at about 21 days of age [18]; (3) total brain protein, which rises rapidly between 12 and 25 days of age [1]; and (4) rates of ganglioside production and sulfatide synthesis [6]. Hommes and Beere [8] have made some similar speculations concerning the relation of development of adenyl cyclase activity in the brain to changes in cerebral electrical activity.…”

Development of Intestinal Adenyl Cyclase and Its Response to Cholera Enterotoxin

“…Although studies of the development of adenyl cyclase activity in animal brain (21), liver (22,23), muscle, and kidney (23) are available, no data have been presented heretofore concerning either the developmental pattern of adenyl cyclase in the intestine or the effect of cholera enterotoxin on the intestine of the fetus or newborn.…”