The development of activity differences in isolated and aggregated mice

Essman, Walter B.

doi:10.1016/s0003-3472(66)80037-4

Cited by 34 publications

(20 citation statements)

References 11 publications

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“…Isolated mice maintained high activity during the 15 min test session. This hyperactivity corresponds with that noted by Fox (1986), Valzelli (1973) and Essman (1966). This indicates that group-reared mice habituate to other mice in an unfamilier environment more easily than isolated mice.…”

Section: Discussionsupporting

confidence: 87%

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Koyama¹

1993

J. Ethol.

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--In previous studies, isolated mice are found to be extremely more aggressive than group-reared mice. In most of those studies, however, the pairings of the groupreared mice were randomly determined, without attention to individuals' ranks in their home cages. In this study, the effect of isolation was analyzed by comparing isolated mice with dominants of group-reared mice. In experiment 1 the group-reared mice were randomly chosen as in previous studies. Isolated mice were significantly more aggressive, but the pairings of the group-reared mice were found to be all dominant vs. subordinate. In experiment 2, the group-reared dominants encountered unfamiliar dominants in an unfamiliar place. Dominant mice were found to be less aggressive than the isolated mice. This result was inconsistent with the "territorial dominant hypothesis" on the hyperaggressiveness of the isolated mice. Sequential analysis of behavior clarified that the isolated mice had a sequential pattern quite different from the group-reared mice, and provided an illustrative figure for the "escalation hypothesis". The lack of aggression in the group-reared mice, however, left a question about the sequence similarity of aggressive behavior in isolated and group-reared mice.

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Section: Discussionsupporting

confidence: 87%

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Koyama¹

1993

J. Ethol.

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“…Previous studies have reported conflicting results: Stern et al (1960), Thiessen et al (1962), Thiessen (1963), and Moyer & Korn (1965) all showed that group-housing leads to an increase in open field activity compared with isolation. The reverse was found by Essman (1966) and Weltman et al (1966). The present experiments vary two parameters which might be important in accounting for these conflicting results-the duration of housing and the sex of the animals-and in addition investigate the possible effects of different group numbers.…”

mentioning

confidence: 69%

“…Besides providing evidence concerning the possible role of social factors in population control (Chrlstian & Davis, 1964;Thiessen, 1964), this area of research has stimulated interest from workers more concerned with experimental psychology (e.g., Essman, 1966Essman, , 1968Moyer & Korn, 1965). The latter approach is characterized by investigations which sacrifice simulation of the natural environment for a greater degree of experimental control, and by theoretical discussions which consider the mechanisms involved in the response of the dependent variables to differences in the social environment (e.g., Welch, 1964).…”

mentioning

confidence: 99%

Contrasting effects of group housing and isolation on subsequent open field exploration in laboratory rats

Archer

1969

Psychon Sci

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“…Interestingly, our mice did show long-term social recognition of a familiar conspecific even after an acute isolation period. Previous studies have shown that after 24 hours of isolation, or chronic isolation, there is a significant long-term social memory impairment in rodents, not only in social recognition memory [19], [20], [60], [61] but also expanding to other social behaviors [66] and cognitive tasks [66], [67], [68]. Indeed, in many ways social interaction is a form of enrichment.…”

Section: Discussionmentioning

confidence: 99%

Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species

Jacobs

Tsien

2012

PLoS ONE

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The ability to learn and remember conspecifics is essential for the establishment and maintenance of social groups. Many animals, including humans, primates and rodents, depend on stable social relationships for survival. Social learning and social recognition have become emerging areas of interest for neuroscientists but are still not well understood. It has been established that several hormones play a role in the modulation of social recognition including estrogen, oxytocin and arginine vasopression. Relatively few studies have investigated how social recognition might be improved or enhanced. In this study, we investigate the role of the NMDA receptor in social recognition memory, specifically the consequences of altering the ratio of the NR2B∶NR2A subunits in the forebrain regions in social behavior. We produced transgenic mice in which the NR2B subunit of the NMDA receptor was overexpressed postnatally in the excitatory neurons of the forebrain areas including the cortex, amygdala and hippocampus. We investigated the ability of both our transgenic animals and their wild-type littermate to learn and remember juvenile conspecifics using both 1-hr and 24-hr memory tests. Our experiments show that the wild-type animals and NR2B transgenic mice preformed similarly in the 1-hr test. However, transgenic mice showed better performances in 24-hr tests of recognizing animals of a different strain or animals of a different species. We conclude that NR2B overexpression in the forebrain enhances social recognition memory for different strains and animal species.

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The development of activity differences in isolated and aggregated mice

Cited by 34 publications

References 11 publications

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Contrasting effects of group housing and isolation on subsequent open field exploration in laboratory rats

Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species

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