The development of a physiologically-based pharmacokinetic model using the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica)

Wintermyer, M. L.; Skaidas, Anna; Roy, Amit; Yu, Yang; Georgapoulos, Panos; Burger, Joanna; Cooper, Keith

doi:10.1016/j.marenvres.2004.08.004

Cited by 11 publications

(4 citation statements)

References 42 publications

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“…These results support that mantle cells or sperm produced during spermatogenesis could be more sensitive to chemicals. A physiologically based pharmacokinetic research on eastern oyster ( Crassostrea virginica ) found tissue-specific bioaccumulation of dioxin after 28-days post exposure to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), suggesting the toxico-kinetics of chemicals are variant in tissues . Using fish as models for environmental carcinogenesis, it has been reported that different tissues respond differently to carcinogens generating different types of tumor .…”

Section: Discussionmentioning

confidence: 99%

Tissue-Specific Expression ofp53andrasGenes in Response to the Environmental Genotoxicant Benzo(α)pyrene in Marine Mussels

Schroeder

Highfield

et al. 2011

Environ. Sci. Technol.

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Marine mussels can develop hemeic and gonadal neoplasia in the natural environment. Associated with these diseases are the tumor suppressor (TS) p53 and the proto-oncogene ras coded proteins, both of which are highly conserved among molluscs and vertebrates. We report, for the first time, tissue-specific expression analysis of p53 and ras genes in Mytilus edulis by means of quantitative RT-PCR. A tissue-specific response was observed after 6 and 12 days exposure to a sublethal concentration of a model Polycyclic Aromatic Hydrocarbon (PAH), benzo(α)pyrene (B(α)P). This sublethal concentration (56 μg/L) was selected based on an integrated biomarker analysis carried out prior to gene expression analysis, which included a 'clearance rate' assay, histopathological analysis, and DNA strand break measurements. The results indicated that the selected concentration of B(α)P can lead to the induction of DNA strand breaks, tissue damage, and expression of tumor-regulating genes. Both p53 and ras are expressed in a tissue-specific manner, which collaborate with tissue-specific function in response to genotoxic stress. The integrated biological responses in Mytilus edulis strengthen the use of this organism to investigate the fundamental mechanism of development of malignancy in invertebrate which could be translated to other organisms including humans.

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Section: Discussionmentioning

confidence: 99%

Tissue-Specific Expression ofp53andrasGenes in Response to the Environmental Genotoxicant Benzo(α)pyrene in Marine Mussels

Schroeder

Highfield

et al. 2011

Environ. Sci. Technol.

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“…Preston et al (2000) In principle, however, there is a need to build a coherent picture of the reproductive endocrinology processes in a representative macroinvertebrate species from a given taxa, together with an understanding of the toxicological processes around xenobiotic absorption, distribution, metabolism and excretion (ADME). Le Curieux-Belfond et al (2005) and Wintermyer et al (2005) have both shown an impressive practical example of invertebrate ADME work using Pacific oysters and Eastern oysters, respectively. The principles of ADME are shown in Fig.…”

Section: Research Recommendation 2-prioritisation Of Selected Laboratmentioning

confidence: 99%

Small is useful in endocrine disrupter assessment—four key recommendations for aquatic invertebrate research

Hutchinson

2007

Ecotoxicology

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As we enter the 21st "biocentury", with issues such as biodiversity and biotechnology growing in public profile, it is important to reflect on the immense ecological, medical and economic importance of invertebrates. Efforts to understand the diverse biology of invertebrates come from many directions, including Nobel Prize winning developmental biology, research to control insects that threaten human health and food supplies, aquaculture opportunities and also within ecotoxicology. In the latter context, this special journal volume highlights the importance of addressing endocrine disruption in aquatic invertebrates, from molecular and cellular biomarkers to population-relevant adverse effects. The contributors to this special volume have provided an excellent assessment of both the fundamental endocrinology and applied ecotoxicology of many aquatic invertebrate groups. On the premise that reproductive success is ultimately the vital population parameter, this chapter gives a personal view of key gaps in knowledge in invertebrate reproductive and developmental endocrinology and ecotoxicology. Based on current knowledge, there are four key issues that need to be prioritised within aquatic ecotoxicology: (1) a wider assessment of the reproductive status of invertebrates in both freshwater and coastal ecosystems; (2) prioritisation of laboratory studies in OECD and other regulatory test organisms, including basic endocrinology and ADME (absorption, distribution, metabolism and excretion) research; (3) development and validation of mechanistic biomarkers that can be used as "signposts" to help prioritise species and chronic test endpoint selection, and help link data from laboratory and field studies; and (4) develop a comparative invertebrate toxicology database utilising the prioritised reference chemicals from the EDIETA workshop, encompassing the diverse modes-of-action pertinent to endocrine disrupter testing in both aquatic arthropod and non-arthropod invertebrates.

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“…As for the population targeted by the model, it was initially more applicable to normal people or adult patients, and now it is also applicable to special populations such as fetuses [ 18 ], newborns [ 19 ], and pregnant women [ 20 ]. Although most PBPK modeling-related applications involve rodents and humans, more species such as sheep [ 21 ], ponies [ 22 ], fish [ 23 ], and oysters [ 24 ], among others, are now also used in physiological modeling exercises.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics

Huang,

Zhao,

Qin

et al. 2024

Toxics

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Physiologically based pharmacokinetic/toxicokinetic (PBPK/PBTK) models are designed to elucidate the mechanism of chemical compound action in organisms based on the physiological, biochemical, anatomical, and thermodynamic properties of organisms. After nearly a century of research and practice, good results have been achieved in the fields of medicine, environmental science, and ecology. However, there is currently a lack of a more systematic review of progress in the main research directions of PBPK models, especially a more comprehensive understanding of the application in aquatic environmental research. In this review, a total of 3974 articles related to PBPK models from 1996 to 24 March 2024 were collected. Then, the main research areas of the PBPK model were categorized based on the keyword co-occurrence maps and cluster maps obtained by CiteSpace. The results showed that research related to medicine is the main application area of PBPK. Four major research directions included in the medical field were “drug assessment”, “cross-species prediction”, “drug–drug interactions”, and “pediatrics and pregnancy drug development”, in which “drug assessment” accounted for 55% of the total publication volume. In addition, bibliometric analyses indicated a rapid growth trend in the application in the field of environmental research, especially in predicting the residual levels in organisms and revealing the relationship between internal and external exposure. Despite facing the limitation of insufficient species-specific parameters, the PBPK model is still an effective tool for improving the understanding of chemical–biological effectiveness and will provide a theoretical basis for accurately assessing potential risks to ecosystems and human health. The combination with the quantitative structure–activity relationship model, Bayesian method, and machine learning technology are potential solutions to the previous research gaps.

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The development of a physiologically-based pharmacokinetic model using the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica)

Cited by 11 publications

References 42 publications

Tissue-Specific Expression ofp53andrasGenes in Response to the Environmental Genotoxicant Benzo(α)pyrene in Marine Mussels

Tissue-Specific Expression ofp53andrasGenes in Response to the Environmental Genotoxicant Benzo(α)pyrene in Marine Mussels

Small is useful in endocrine disrupter assessment—four key recommendations for aquatic invertebrate research

Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics

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