The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H
N. Z. Mehjardi,
J. Kessler,
A. Y. Sanin
et al.
Abstract:The application of patient-derived (PD) in vitro tumor models represents the classical strategy for clinical translational oncology research. Using these cellular heterogeneous cultures for the isolation of cancer stem cells (CSCs), suggested to be the main driver for disease malignancy, relies on the use of surrogate biomarkers or is based on CSC-enriching culture conditions. However, the ability of those strategies to exclusively and efficiently enrich for CSC pool has been questioned. Here we present an alt… Show more
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