Abstract:e15050 Background: Complex tumor tissue is composed of malignant cells and diverse tumor microenvironment (TME) cellular populations. Depending on the cancer type, the percentage of malignant cells present in tumor tissue varies, with percentages sometimes below 10%. TME cellular transcripts may comprise the majority of the total transcripts in a tumor, potentially resulting in biases during biomarker development and for clinical decision-making. However, TME gene expression can be subtracted from total tumor… Show more
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