The Development, Characterization and Application of Water Soluble Chitosan

Ujang, Zanariah; Diah, Mazita Md; Rashid, Ahmad Hazri Abdul; Halim, Ahmad Sukari

doi:10.5772/16771

Cited by 15 publications

(11 citation statements)

References 44 publications

(18 reference statements)

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“…For the polymers used, all used polymers matched with published data [15,17,21,[23][24][25][26][27][28][29][30]. While it can be observed for that higher molecular weight chitosan (16 kDa) exhibited more spherical shape.…”

Section: Discussionsupporting

confidence: 63%

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

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Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release. Conclusion:The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

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Section: Discussionsupporting

confidence: 63%

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

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“…Other absorption bands observed at 3261, 2878 and 1153 cm −1 were attributed to O–H, C–H and C–O stretching vibrations, respectively, thereby confirming that the purified material was indeed chitin [14]. The infra-red spectrum of chitosan (Figure 2) exhibited a characteristic band at 3361 cm −1 attributed to the stretching vibration of the inter- and intra-molecular hydrogen bonds from the –NH 2 and –OH groups, being similar to the previously-reported results [15]. The weak absorption band at 2925 cm −1 was assigned to sp 3 C–H stretching vibrations.…”

Section: Resultssupporting

confidence: 87%

“…The higher intensity of this peak in chitosan compared to that observed in chitin and subsequent shortening of the peak intensity due to C=O stretch at 1651 cm −1 (Figure 2) indicates that deacetylation was successful [16,17]. The peak for the asymmetric stretch of C–O–C was observed at 1151 cm −1 [15,18,19]. The peaks at 1651 and 1372 cm −1 were attributed to C=O and C–N stretching vibration as amide I and amide III of chitosan, respectively [15].…”

Section: Resultsmentioning

confidence: 99%

“…The peak for the asymmetric stretch of C–O–C was observed at 1151 cm −1 [15,18,19]. The peaks at 1651 and 1372 cm −1 were attributed to C=O and C–N stretching vibration as amide I and amide III of chitosan, respectively [15]. …”

Section: Resultsmentioning

confidence: 99%

“…The STA/DTG curve of chitosan (Figure 6A) shows the first thermal event that occurred in the temperature range of 50 to 85 °C being associated with 27.6% weight loss assigned to dehydration [15,21,22,23,24,25,26]. The second event of thermal decomposition observed from 210 to 390 °C was associated with 50.1% weight loss due to degradation of the chitosan polymer.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Preparation, Characterization and in Vivo Antimycobacterial Studies of Panchovillin-Chitosan Nanocomposites

Rwegasila

Mubofu

Nyandoro

et al. 2016

IJMS

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Chitosan (CS, molecular weight 20.2 kDa, degree of deacylation (DD) 73.31%) was successfully obtained by deacetylation of chitin extracted from shrimp (Litopenaeus vannamei) shell wastes. The encapsulation of the bioactive natural product, panchovillin (PANV), isolated from Erythrina schliebenii, on a chitosan-tripolyphosphate (CS/TPP) nano-framework was achieved by ionotropic gelation. Characterization of pure CS, CS/TPP and PANV-CS/TPP nanocomposites was performed by FTIR, SEM and XRD. The molecular weight of chitosan and the thermal stability of the materials were determined by MALDI-TOF-MS and simultaneous thermal analyzer (STA)/DTG, respectively. The respective encapsulation efficiency and loading capacity of the PANV were found to be 70% and 0.36%. The in vitro release studies showed an initial burst of 42% of PANV in the first six hours. This was followed by a slow and sustained release up to 72 h. The in vivo antimycobacterial activities of both PANV and PANV-CS/TPP nanocomposite against Mycobacterium indicus pranii (MIP) using Galleria mellonella larvae as an in vivo infection model are reported in this paper.

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