The development and phylogeny of the corpuscle of stannius in ganoid and teleostean fishes

Garrett, Frederic D.

doi:10.1002/jmor.1050700104

Cited by 59 publications

(21 citation statements)

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“…The proximal tubules, loops of Henle, maculae densae and distal convoluted tubules have a different origin, however, being derived instead from the metanephrogenic blastema (Ekblom 1992, Clapp & Abrahamson 1994. Because fish STC cells also arise from the pronephric/mesonephric duct (Garrett 1942, Wendelaar Bonga & Pang 1986, Kaneko et al 1992, this implies that the STC cells in fish and those in mammalian kidney share a common embryological origin, the only difference being that the mammalian cells remain at their site of ontogeny instead of coalescing into discrete glands. It is interesting to note that the CS glands in the most primitive bony fishes also remain closely associated with the nephrons like those in mammalian kidney (Youson & Butler 1976), but it remains to be seen if these differences in anatomy translate into differences in function.…”

Section: Discussionmentioning

confidence: 99%

“…CS are derived from the pronephric/mesonephric ducts (Garrett 1942, Wendelaar Bonga & Pang 1986, Kaneko et al 1992 and are located on the surface of the kidneys in most fish species. Elevated plasma calcium levels stimulate the secretion of STC, which is released into the circulation to inhibit gill and intestinal calcium transport (So & Fenwick 1977, 1979, Wagner et al 1986, 1988, Sundell et al 1992) and the renal excretion of inorganic phosphate (Pi) in order to restore normocalcemia (Lu et al 1994).…”

Section: Introductionmentioning

confidence: 99%

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The co-localization of stanniocalcin protein, mRNA and kidney cell markers in the rat kidney

Wong¹,

Ho²,

Wagner³

1998

Journal of Endocrinology

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Stanniocalcin (STC) is a glycoprotein hormone that was first discovered in fish and recently identified in mammals. STC immunoreactive (STCir) cells have been identified in rat kidney and there is also evidence that the hormone functions as a regulator of renal phosphate homeostasis. In the present study we have identified STCir cells and tubules in the rat kidney by correlative immunocytochemistry using antibodies to STC and specific antigenic markers (Tamm-Horsfall protein and anion exchanger-1). The cellular sites of STC gene expression were also identified by in situ hybridization. Correlative immunocytochemistry revealed that STCir was present in all proximal straight tubule cells, all cortical thick ascending limb cells, all distal convoluted tubule cells, and both principal and -intercalated cells of the collecting duct system. On the other hand, in situ hybridization revealed that the STC gene was expressed only in cortical and medullary collecting duct cells. This suggests either that STC is being sequestered by segments that do not express the gene (making them putative targets of the hormone), or that STC mRNA levels were simply too low in these other segments to be detected by in situ hybridization.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The co-localization of stanniocalcin protein, mRNA and kidney cell markers in the rat kidney

Wong¹,

Ho²,

Wagner³

1998

Journal of Endocrinology

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“…In the bowfin, however, several hundred CS were scattered throughout the opisthonephros in hemopoietic-rich re gions and in areas with abundant nephric tissue, still maintaining a close association with the distal renal tubules from which they are assumed to emanate (You son et al 1976: Marra et al 1992. The number and distri bution of bowfin CS perhaps reflect the ancestral organi zation of the corpuscles of Stannius (Garrett 1942;de Smet 1962;. Both garpike and bowfin CS are closely associated with an adrenocortical ho molog Bhattacharyya et al 1982).…”

Section: Discussionmentioning

confidence: 99%

Immunoreactivity of the corpuscles of Stannius of the garpike, Lepisosteus osseus , to antisera against salmon and trout stanniocalcins

Marra¹,

Youson²,

Bonga³

et al. 1994

Cell and Tissue Research

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Abstract. Stanniocalcin-immunoreactive cells were local ized in the corpuscles of Stannius of a holostean fish, the garpike (Lepisosteus osseus), using antisera against salmon and trout stanniocalcins and the peroxidase-antiperoxidase and protein A-gold immunohistochemical methods. The stanniocalcin-immunoreactive cells were periodic acid-Schiff-positive, and antibody staining was abolished if the antiserum was preabsorbed with corpus cle homogenate. Immunocytochemistry revealed two re active cell types in the glandular parenchyma, and im munoreactivity was confined to the secretory granules. Staining of the granules was also abolished when the antisera were blocked with crude corpuscle homogenate. When corpuscle extracts from garpike were subjected to sodium dodecyl sulphate-polyacrylamide gel elec trophoresis and Western blot analysis, a single dense band was evident with a molecular weight of ^68 kDa under non-reducing conditions, whereas three bands were observed (^29, -31, and ^3 4 kDa) under reduc ing conditions. Staining of all bands disappeared follow ing preabsorption of the antiserum with salmon stanniocalcin, trout stanniocalcin, or garpike corpuscle extract. The results are compared with stanniocalcins from an other extant holostean, the bowfin (Amia calva), and from more modern bony fishes, the teleosts.

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“…Previous researches into the CS of fish suggested that they are embryologically derived from the pronephric and/or mesonephric ducts (Garrett, 1942;Kaneko et al, 1992). The bowfin (Amia cal6a) is the most ancient extinct species know to possess these glands and it has several hundred CS many of which have an intimate association with distal renal tubules (Youson et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Stanniocalcin from an ancient teleost: a monomeric form of the hormone and a possible extracorpuscular distribution

Amemiya

Marra

Reyhani

et al. 2002

Molecular and Cellular Endocrinology

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Stanniocalcin (STC) is a homodimeric glycoprotein hormone implicated in calcium and phosphate regulation in both teleost fish and mammals. In the present study, immunostaining with salmon STC antiserum demonstrated that STC cells were localized in both the corpuscles of Stannius (CS) and in specific cells of the distal renal tubules of the silver arawana, Osteoglossum bicirrhosum, an ancient ray-finned fish (actinoptergian) and basal teleost (Order Osteoglossiforme). The morphology of these STC-immunoreactive kidney cells was similar to renal 'chloride' (mitochondrial-rich) cells. The immunoreactive renal cells were present in two of three other osteoglossiformes and absent in the gar, a nonteleost actinopterygian and the eel, another basal teleost. The arawana STC cDNA encodes a prehormone of 249 amino acids (aa) with a signal peptide of 31 aa and a mature protein of 218 aa. The deduced aa sequence of arawana STC shows 54 -66% identity with other teleost STCs and 51 -52% identity with mammalian STC-1. The deduced aa sequence of arawana STC contains ten cysteines, compared with 11 in teleost STC and in mammalian STC-1. The cysteine substitution occurs at the site of inter-monomeric disulfide linkage. Western blot analysis revealed a single 21 kDa band under non-reducing conditions, and a single band of 25 kDa under reducing conditions. These data indicate that arawana STC exists as a monomeric peptide. Northern blot analysis detected a 3.3 kb STC mRNA confined to the CS, with no hybridization signal in either the remaining kidney or in gut, muscle, brain and heart. The significance of the STC signal in cells of the renal tubules of arawana and two other Osteoglossiforme species requires further investigation. This is the first report of a monomeric form of STC in any vertebrate and the first evidence of STC in renal tubules of adult fish.

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The development and phylogeny of the corpuscle of stannius in ganoid and teleostean fishes

Cited by 59 publications

References 2 publications

The co-localization of stanniocalcin protein, mRNA and kidney cell markers in the rat kidney

The co-localization of stanniocalcin protein, mRNA and kidney cell markers in the rat kidney

Immunoreactivity of the corpuscles of Stannius of the garpike, Lepisosteus osseus , to antisera against salmon and trout stanniocalcins

Stanniocalcin from an ancient teleost: a monomeric form of the hormone and a possible extracorpuscular distribution

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