The development and efficacy of a mobile phone application to improve medication adherence for persons with epilepsy in limited resource settings: A preliminary study

Mirpuri, Pranav; Chandra, P Prarthana; Samala, Raghu; Agarwal, Mohit; Doddamani, Ramesh; Kaur, Taranjit; Ramanujan, Bhargavi; Chandra, P. Sarat; Tripathi, Manjari

doi:10.1016/j.yebeh.2021.107794

Cited by 15 publications

(13 citation statements)

References 37 publications

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“…However, in a meta-analysis review study by Xu et al, it was stated that while electronic-health based self-management had a significant effect on the fatigue and self-efficacy of cancer patients, it did not improve the quality of life significantly [ 45 ]. Similar to the result of present study, in the studies by Mirpuri et al [ 46 ], and Choi et al [ 23 ], the smartphone application increased the meanself-efficacy score of the patients with epilepsy. The smartphone application increased the participants' self-efficacy among patients with various conditions in all of the aforementioned investigations.…”

Section: Discussionsupporting

confidence: 92%

Comparing the effects of self- care education by lecture and smartphone application on self-efficacy of patients with thalassemia

Kharaman-nia

Rezaei

Roustaei

et al. 2023

BMC Med Inform Decis Mak

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Background Patients with the thalassemia have a basic requirement for self-efficacy regarding their treatment procedure. The present study aimed to compare the effect of self-care education via a smartphone application and lectures on the self-efficacy of patients with thalassemia. Methods In the present quasi-experimental study, 99 patients with thalassemia at Shahid Beheshti Hospital in Yasuj, Iran, in 2019 who were eligible to enter the study, were selected. The block randomization was done with the block sizes of 3, 6, and 9, and participants were randomly assigned to 3 groups: smartphone application (A), lecture intervention (B), and control (c). Smartphone application and lecture interventions were performed for intervention groups A and B, respectively, during 8 weeks. Scherer's self-efficacy measure was used to collect the data at baseline and eight weeks after the intervention. Data were analyzed by SPSS-version 25 software using Paired t-test, Wilcoxon and Kruskal–Wallis tests. Results Ninety-nine patients with thalassemia with a mean (SD) age of 25 (6) and 58 females (58.59%) participated in the present study. The results indicated a significant difference in self-efficacy among 3 groups after intervention (P = 0.001). However, self-care education with smartphone application revealed a significant increase in the mean (SD) of self-efficacy of the patients with thalassemia 68.36(8.45) compared to the lecture method 62.55 (7.3) (P = 0.003) and control 62.09 (6.7) (P = 0.001). There were no significant differences among the self-efficacy scores of the patients in lecture intervention and control groups. Conclusions The results revealed that smartphone application was a suitable educational software to promote self-efficacy in patients with thalassemia. It is recommended to use smartphone application methods to improve the self-efficacy levels of patients with thalassemia.

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Section: Discussionsupporting

confidence: 92%

Comparing the effects of self- care education by lecture and smartphone application on self-efficacy of patients with thalassemia

Kharaman-nia

Rezaei

Roustaei

et al. 2023

BMC Med Inform Decis Mak

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“…Another important factor was the adverse effects of the anti-epileptic drugs taken [ 28 , 36 , 37 ]. To minimize the risk of skipping a dose, it is recommended to use pill organizers, taking medication during meals and using reminder mobile applications [ 12 , 38 , 39 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Epilepsy’s Medical Recommendations

Jopowicz,

Piechal,

Bronisz

et al. 2024

Brain Sciences

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The primary problem in the treatment of epilepsy is poor seizure control. Several studies have shown that non-adherence to doctors’ recommendations regarding drug dosage, time of drug administration as well as lifestyle modifications are the most frequent causes of the persistence or reoccurrence of seizures, other than cases of misdiagnosis and poor drug selection. The aim of this study was to assess the prevalence of non-compliance with medical recommendations, both in relation to medicine dosage, regularity of administration and lifestyle, and also to determine the factors affecting patients with diagnosed epilepsy. This study was carried out on a total of 169 patients diagnosed with epilepsy who were under the care of an outpatient neurology clinic. The assessment of compliance was performed using the Patient Rating of Compliance Scale (PRCS), Clinician Rating Scale (CRS) and authors’ scale. Depending on the scale used, varying degrees of non-compliance were noted. They were as follows—65.3% on the authors’ scale, 10% on the PRCS and 9% on the CRS. The following factors influenced compliance with doctors’ recommendations: type of epilepsy, consumption of alcoholic beverages, frequency of follow-up visits to the neurology clinic, type of pharmacotherapy and number of medicines taken.

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“…studies where patients pointed out that personalization by navigating to the topics that interested them (e.g., news about their medications) or setting personal goals was important. 49,50 Furthermore, Koo et al point out that the users' satisfaction is critical to their motivation and continuous website usage. 49 In our study, several non-completers pointed out technical difficulties with accessing the app and a lack of reminders to access and use the app.…”

Section: T a B L Ementioning

confidence: 99%

A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy

Michaelis,

Knake,

Rosenow

et al. 2024

Epilepsia Open

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ObjectiveSelf‐management interventions may enhance health‐related quality of life (HRQoL) in epilepsy. However, several barriers often impair their implementation in the real world. Digital interventions may help to overcome some of these barriers. Considering this, the Helpilepsy Plus Prototype was developed as a prototype smartphone‐delivered self‐care treatment program for adults with epilepsy.MethodsThe 12‐week Helpilepsy Plus Prototype was evaluated through a randomized controlled feasibility trial with a waiting‐list control (WLC) group. Outcome measurement at baseline and at 12 weeks assessed adherence to the prototype intervention and changes in epilepsy‐related outcomes. The primary endpoint was patient autonomy measured with EASE, and secondary endpoints included HRQoL measured with QOLIE‐31, health literacy measured with HLQ, anxiety, and depression symptoms measured with HADS. Semi‐structured interviews were conducted with a heterogeneous sample of participants to assess user‐friendliness and usefulness. The prototype program was delivered through the Neuroventis Platform (Neuroventis, BV, Overijse, Belgium), a certified medical device (under EU/MDD Class I, and EU/MDR grace period).ResultsNinety‐two patients were included (46 in the intervention group, 46 in WLC). Most participants (63%, 58/92 women, median age 30 years) had pharmacoresistant epilepsy (61%, 56/92). Only 22% of participants (10/46) in the intervention group completed at least half of all intervention sessions. No significant differences between the intervention group and WLC were observed. Although there was a larger proportion of patients in the intervention group with meaningful improvements in HRQoL compared to WLC (19/46 versus 11/46), the difference was not significant (p = 0.119). Qualitative feedback showed that participants would appreciate more personalization, such as adaptation of the content to their current epilepsy knowledge level, a more interactive interface, shorter text sections, and interaction through reminders and notifications.SignificanceDigital interventions should allow sufficient scope for personalization and interaction to increase patient engagement and enable benefits from self‐care apps. Feedback loops allow the participatory development of tailored interventions.Plain Language SummaryIn this study, we investigated the effectiveness of an app‐based self‐help intervention. Study participants were either randomly assigned to a group that had access to the app or a group that received access to the app after the end of the study. Although a larger proportion of participants in the intervention group showed a relevant improvement in quality of life, the difference between the two groups was not statistically significant. Less than one‐fifth of participants in the intervention group attended at least half of all intervention sessions; patient feedback showed that patients required more personalization and interactive options.

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The development and efficacy of a mobile phone application to improve medication adherence for persons with epilepsy in limited resource settings: A preliminary study

Cited by 15 publications

References 37 publications

Comparing the effects of self- care education by lecture and smartphone application on self-efficacy of patients with thalassemia

Comparing the effects of self- care education by lecture and smartphone application on self-efficacy of patients with thalassemia

Adherence to Epilepsy’s Medical Recommendations

A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy

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