The development and controversy of competitive endogenous RNA hypothesis in non-coding genes

Lin, Weimin; Liu, Hongcheng; Tang, Yonghang; Wei, Yuchen; Wei, Wei; Zhang, Lifan; Chen, Jie

doi:10.1007/s11010-020-03889-2

Cited by 40 publications

(34 citation statements)

References 141 publications

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“…An increasing number of studies have suggested that many circRNAs contain MREs, which play a role through the circRNA-miRNA-mRNA regulatory network [ 27 , 28 ]. In this regulatory network, circRNAs function as ceRNAs to regulate the gene expression of miRNA targets.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA expression profile in transgenic diabetic mouse kidneys

et al. 2021

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Background Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNAs (circRNAs) play crucial regulatory roles in numerous human diseases and normal physiology; however, to date, no study has focused on the comprehensive expression profile of circRNAs in the kidneys of diabetic mice. Therefore, we aimed to identify differentially expressed circRNAs in diabetic mouse kidneys to explore the possible roles of dysregulated circRNAs in diabetic nephropathy development. Results Diabetic BKS-Leprem2Cd479/Nju (BKS-DB/Nju) mice and their nondiabetic wild-type littermates of C57BL/KsJ wild-type (WT) mice were used as experimental animals. Among all circRNAs identified by high-throughput RNA sequencing, four circRNAs were upregulated and ten were downregulated in diabetic mouse kidneys compared to those in nondiabetic mouse kidneys. After verification using quantitative reverse transcriptase polymerase chain reaction assays, we found that circR_1084, circR_182, circR_4, circR_50, circR_596, circR_897, and circR_203 were downregulated, whereas circR_627, circR_628, circR_735, and circR_801 were upregulated in the renal tissues of 8- and 16-week-old BKS-DB/Nju mice compared to those in WT mice. Conclusion We studied the circRNA expression profile in the kidneys of diabetic mice. Differentially expressed circRNAs may be useful as candidate biomarkers for diabetic nephropathy. Collectively, our results provide a novel theoretical basis for further investigation of the regulatory roles of circRNA in the etiology and pathogenesis of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Circular RNA expression profile in transgenic diabetic mouse kidneys

et al. 2021

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“…Recently, ceRNA hypothesis has been demonstrated to represent a novel model of post-transcriptional regulation working through miRNA competition (25). In the ceRNA network, ceRNA can inhibit multiple miRNAs and regulate the network by changing the type and number of miRNA binding sites, involving various signaling pathways and biological phenomena (22,25). Further study on the mechanism of ceRNA will help to deepen the understanding of the pathogenesis of the disease, and has a good application prospect in disease treatment.…”

Section: Discussionmentioning

confidence: 99%

“…According to recent studies, lncRNAs form a competitive endogenous RNA (ceRNA) through sponge adsorption of miRNA to regulate mRNA expression (21). The ceRNA hypothesis believes that lncRNAs and other transcripts can competitively bind miRNAs to prevent them from binding to mRNA thereby regulate mRNA expression (22).…”

Section: Introductionmentioning

confidence: 99%

Exploring Long Non-coding RNA Potential Markers for Prognosis Risk based on Double Hormone Receptor Positive Breast Cancer CeRNA Network

Huang¹,

Yao²,

Wu³

et al. 2021

Preprint

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Purpose: The aim of this study is to search for key long non-coding RNA (lncRNAs) able to influence the prognosis of double hormone receptor positive (ER+PR+) breast cancer by constructing a competing endogenous RNA (ceRNA) topology network of RNA-seq data and miRNA-seq data. Materials and methods: Based on The Cancer Genome Atlas (TCGA), we downloaded RNA-seq data and miRNA-seq data of ER+PR+ breast cancer and obtained lncRNA-miRNA relationship pairs by comparing with the data in moRcode database. MiRDB, miRTarBase and TargetScan databases were used to predict target genes, and thereby gaining miRNA-mRNA relationship pairs. The ceRNA network was constructed using Cytoscape, then functional enrichment analysis was performed. Cox survival analysis was carried out to explore the potential prognostic lncRNAs.Results: A ceRNA topology network was constructed and six lncRNAs, PSORS1C3, AC010536.2, IQCF5-AS1, AL021707.1, FGD5-AS1, and PART1, were found to be mostly associated with the survival of ER+PR+ breast cancer. Conclusion: Six lncRNAs with prognostic significance were identified in ER+PR+ breast cancer, providing new ideas for the diagnose and treatment of this subtype.

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“…circRNAs act as miRNA Sponges miRNAs play the post-transcriptional regulation with target genes in which it is referred to as miRNA response elements (MREs). A single miRNA is able to target multiple genes with consistent MREs, thus describing the so-called competing endogenous RNA (ceRNA) network (Limb et al, 2020;Lin et al, 2020). Currently, the research of ceRNAs' effects covers a wide range of subjects, involving many ncRNAs, including lncRNA, circRNAs, pseudogenes, and viral transcripts (Lin et al, 2020).…”

Section: Synthesis and Biological Characteristics Of Circrnasmentioning

confidence: 99%

“…A single miRNA is able to target multiple genes with consistent MREs, thus describing the so-called competing endogenous RNA (ceRNA) network (Limb et al, 2020;Lin et al, 2020). Currently, the research of ceRNAs' effects covers a wide range of subjects, involving many ncRNAs, including lncRNA, circRNAs, pseudogenes, and viral transcripts (Lin et al, 2020). miRNA sponging is presently recognized as the main mechanism that circRNAs are involved in (Limb et al, 2020).…”

Section: Synthesis and Biological Characteristics Of Circrnasmentioning

confidence: 99%

Emerging Roles of Circular RNAs in Thyroid Cancer

Xia

Zhang

2021

Front. Cell Dev. Biol.

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Thyroid cancer (TC) has the highest incidence among endocrine malignancies. Thus, it is essential to achieve a deep understanding of various mechanisms of development and progression of TC. circRNAs are recognized by multiple studies as being dysregulated in TC. Accumulating evidences have revealed that circRNAs serve as regulatory molecules involved in various biological processes in TC, including cell proliferation, apoptosis, invasion/migration, metabolism, and chemoresistance. Furthermore, circRNA can also serve as an effective tool in TC researches of diagnosis, prognosis, and treatments. Thus, this review is to outline the characteristics of circRNAs, generalize their categories and functions, and highlight the expression of circRNAs in TC. Meanwhile, we are expecting to achieve a comprehensive understanding of new therapies based on circRNAs in treating or preventing TC.

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The development and controversy of competitive endogenous RNA hypothesis in non-coding genes

Cited by 40 publications

References 141 publications

Circular RNA expression profile in transgenic diabetic mouse kidneys

Circular RNA expression profile in transgenic diabetic mouse kidneys

Exploring Long Non-coding RNA Potential Markers for Prognosis Risk based on Double Hormone Receptor Positive Breast Cancer CeRNA Network

Emerging Roles of Circular RNAs in Thyroid Cancer

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