The Developing World Urgently Needs Phages to Combat Pathogenic Bacteria

Nagel, Tobi E.; Chan, Benjamin K; Vos, Daniël De; El‐Shibiny, Ayman; Kang’ethe, Erastus K.; Makumi, Angela; Pirnay, Jean‐Paul

doi:10.3389/fmicb.2016.00882

Cited by 66 publications

(57 citation statements)

References 17 publications

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“…phage as a biocontrol treatment) must be developed to decrease the rate of infection from agricultural animals. Additionally, the development of phage therapies may be attractive alternatives for treating Campylobacter infection in patients in the developing world since they are relatively cheap to produce, spare the commensal microbiota (particularly important for malnourished and immunocompromised patients), and can be dry powder formulated so that no refrigeration is necessary (36). The ability to eliminate Campylobacter in a specific manner is particularly important in developing nations since the gastrointestinal dysbiosis caused by traditional antibiotics puts patients at a further disadvantage for digestion and nutrient acquisition (3,37).…”

Section: Resultsmentioning

confidence: 99%

Moderate-Throughput Identification and Comparison of Campylobacter-Infecting Bacteriophages

Tj¹,

Jm²,

Patel³

et al. 2017

Preprint

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Word Count: 198 Text Word Count: 4875Abstract Campylobacter jejuni is a leading cause of foodborne infection due to its ability to asymptomatically colonize agricultural animals. In addition to its prevalence, Campylobacter is becoming increasingly resistant to the clinical antibiotics, azithromycin and ciprofloxacin. As a result, public health agencies have identified drug resistantCampylobacter as a serious threat to public health and have suggested combating the pathogen at the farm-level by reducing its burden within agricultural animal reservoirs.isolating bacteriophage that infect C. jejuni from various environmental sources. In previous studies, bacteriophage that kill C. jejuni have been isolated from sewage and pig manure; however, the majority have been isolated from chickens, and have been relatively few in number. We postulate this study increases the likelihood of isolating bacteriophage efficacious at combating C. jejuni colonization of agricultural animal hosts at the farm-level or treating infected humans.

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Section: Resultsmentioning

confidence: 99%

Moderate-Throughput Identification and Comparison of Campylobacter-Infecting Bacteriophages

Tj¹,

Jm²,

Patel³

et al. 2017

Preprint

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“…In addition, high levels of the nuclease Cas9 relative to sgRNA helps reduce the incidence of off-target effects [72]. The Cas9 nuclease can be further engineered into a nickase, which only cleaves a single strand of DNA and the same strategy on the other strand enhances the specificity of site recognition and consistently minimizes off-target effects [67,[70][71][72][73].…”

Section: Cons Of Crisprs For Genome Editingmentioning

confidence: 99%

“…The prospect of novel, efficient AMPs is a crucial starting point to combat antibiotic-resistant microbial pathogens. The emergence of MDR bacteria is a tremendous global health problem that has been predicted to lead to the death of 10 million humans per year by 2050 [73]. Microbes, plants, and animals are natural sources of therapeutic drugs and could also be a source of novel, biologically inspired, previously unknown antibiotics for human applications.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts

Cunha

Cobacho

Viana

et al. 2017

Drug Discovery Today

148

101

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Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis.

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“…Their benefit could be larger if phage products are accessible in developing countries, For instance, given the shortage of dependable refrigeration in many lower income countries like Ethiopia, meat products are preferably sold within twenty four hours of butcher. Thus, any antibacterial agent that could augment the shelf life even by one day possibly will have significant impacts not only on the health of community, but also on profitability for meat seller 84 .…”

Section: A New Insight In Ethiopiamentioning

confidence: 99%

“…Studies have verified that Campylobacter is inhabitant in the gastrointestinal tracts of up to 75% of poultry in many countries 85 . Thus, bacteriophages could be utilized to reduce bacterial loads in animals before they arrive at butcher houses 84 . Agriculture is among the vital economic sectors in Ethiopia and bacterial infections that were more difficult to control secondary to bactericide resistance are the main intimidation to agricultural production of food.…”

Section: A New Insight In Ethiopiamentioning

confidence: 99%

Bacteriophages and their applications: general aspects and a new insight in Ethiopia

Nureye

Assefa

Mohammed

2018

J. Drug Delivery Ther.

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Bacteriophages, having a variety of function in different disciplines, are viruses that invade bacterial cells. Phages are enormously essential to the ecology and evolution of bacteria, and have huge impacts on global weather patterns. Due to their easiness to manipulate, they have been used in dissimilar types of genetic analysis and also implemented in hydrological tracing. Modified filamentous bacteriophages can be used in the production of nanodevices and as an agent in extraction of triacylglycerols. While their invention over a decade, they have been subjugated mainly to treat infections caused by bacteria. Phage therapy could become a welcome option in this era with a paucity of new antibiotic to battle against multi-drug resistant pathogens. This enemy of bacteria can also be used to combat antimicrobial resistance. This annotation is tried to touch the current progress in bacteriophage research and applications including biocontrols, diagnostic purposes, drug innovation and new drug delivery systems. Regarding efforts made in Ethiopia, there is limited study on isolation of phage and their therapeutic potential. Antibiotic resistance is of major community health concern in Ethiopia. Hence, the idea of using bacteriophage should be taken into consideration and health professionals should have to show inclination towards phage therapy. Moreover, substantial academic efforts have to be made before approval of phage utilization in Ethiopia.

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The Developing World Urgently Needs Phages to Combat Pathogenic Bacteria

Cited by 66 publications

References 17 publications

Moderate-Throughput Identification and Comparison of Campylobacter-Infecting Bacteriophages

Moderate-Throughput Identification and Comparison of Campylobacter-Infecting Bacteriophages

The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts

Bacteriophages and their applications: general aspects and a new insight in Ethiopia

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