The developing mouse dopaminergic system: Cortical-subcortical shift in D1/D2 receptor balance and increasing regional differentiation
Ingvild E. Bjerke,
Harry Carey,
Jan G. Bjaalie
et al.
Abstract:The dopaminergic system of the brain is involved in complex cognitive functioning and undergoes extensive reorganization during development. Yet, these changes are poorly characterized. We have quantified the density of dopamine 1- and 2-receptor (D1 and D2) positive cells across the forebrain of male and female mice at five developmental stages. Our findings show a cortico-subcortical shift in D1/D2 balance, with increasing D1 dominance in cortical regions as a maturational pattern that occurs earlier in fema… Show more
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