The developing airway and gut microbiota in early life is influenced by age of older siblings

Christensen, Emil Dalgaard; Hjelmsø, Mathis Hjort; Thorsen, Jonathan; Shah, Shiraz; Redgwell, Tamsin; Poulsen, Christina Egeø; Trivedi, Urvish; Russel, Jakob; Gupta, Shashank; Chawes, Bo L.; Bønnelykke, Klaus; Sørensen, Søren Johannes; Rasmussen, Morten Arendt; Bisgaard, Hans; Stokholm, Jakob

doi:10.1186/s40168-022-01305-z

Cited by 28 publications

(20 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Having older siblings influences the development of the bacterial community in early life 49–51 and here we show that having older siblings is also associated with gut virome composition at one year of age. Importantly, from a translational angle, early-life exposures may affect the establishment of health phenotypes, such as the protective role of breastfeeding against eukaryotic-viral infections in the neonatal period 30 .…”

Section: Discussionsupporting

confidence: 56%

The influence of early life exposures on the infant gut virome

Zhang

Castro‐Mejía

Deng

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

SummaryLarge cohort studies have contributed significantly to our understanding of the factors that influence the development of the bacterial component of the gut microbiome (GM) during the first years of life. However, the factors that shape the colonization by other important GM members such as the viral fraction remain more elusive. Most gut viruses are bacteriophages (phages), i.e., viruses attacking bacteria in a host specific manner, and to a lesser extent, but also widely present, eukaryotic viruses, including viruses attacking human cells. Here, we utilize the deeply phenotyped COPSAC2010 birth cohort consisting of 700 infants to investigate how social, pre-, peri- and postnatal factors may influence the gut virome composition at one year of age, where fecal virome data was available from 645 infants.Among the different exposures studied, having older siblings and living in an urban vs. rural area had the strongest impact on gut virome composition. Differential abundance analysis from a total of 16,118 viral operational taxonomic units (vOTUs) (mainly phages, but also 6.1% eukaryotic viruses) identified 2,105 vOTUs varying with environmental exposures, of which 5.9% were eukaryotic viruses and the rest was phages. Bacterial hosts for these phages were mainly predicted to be within theBacteroidaceae, Prevotellaceae, andRuminococcaceaefamilies, as determined by CRISPR spacer matches. Spearman correlation coefficients indicated strong co-abundance trends of vOTUs and their targeted bacterial host, which underlined the predicted phage-host connections. Further, our findings show that some gut viruses encode important metabolic functions and how the abundance of genes encoding these functions is influenced by environmental exposures. Genes that were significantly associated with early life exposures were found in a total of 42 vOTUs. 18 of these vOTUs had their life styles predicted, with 17 of them having a temperate lifestyle. These 42 vOTUs carried genes coding for enzymes involved in alanine, aspartate and glutamate metabolism, glycolysis-gluconeogenesis, as well as fatty acid biosynthesis. The latter implies that these phages could be involved in the utilization and degradation of major dietary components and affect infant health by influencing the metabolic capacity of their bacterial host.Given the importance of the GM in early life for maturation of the immune system and maintenance of metabolic health, these findings provide a valuable source of information for understanding early life factors that predispose for autoimmune and metabolic disorders.

show abstract

Section: Discussionsupporting

confidence: 56%

The influence of early life exposures on the infant gut virome

Zhang

Castro‐Mejía

Deng

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Further studies are needed to address this question. Likewise, human studies have verified that the bacteria are vertically transferred from mother to infant by breast feeding ( Pannaraj et al, 2017 ; Wang S. et al, 2020 ), they can also be determined by older siblings in the home ( Christensen et al, 2022 ). Other perinatal conditions like type of feeding, lifestyle, and environmental exposure can also modulate the development and maturation of the infant gut microbiota in human children ( Derrien et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance via modulation of the microbiota-gut-brain axis

Zhou

Sun

2023

Front. Microbiol.

View full text Add to dashboard Cite

IntroductionPrenatal and early postnatal development are known to influence future health. We previously reported that prenatal high estradiol (HE) exposure induces insulin resistance in male mice by disrupting hypothalamus development. Because a foster dam can modify a pup’s gut microbiota and affect its health later in life, we explored whether surrogate fostering could also influence glucose metabolism in HE offspring and examined mechanisms that might be involved.MethodsWe performed a surrogate fostering experiment in mice and examined the relationship between the metabolic markers associated to insulin resistance and the composition of the gut microbiota.ResultsHE pups raised by HE foster dams (HE-HE) developed insulin resistance, but HE pups fostered by negative control dams (NC-HE) did not. The gut microbiota composition of HE-HE mice differed from that of NC mice raised by NC foster dams (NC-NC), whereas the composition in NC-HE mice was similar to that of NC-NC mice. Compared with NC-NC mice, HE-HE mice had decreased levels of fecal short-chain fatty acids and serum intestinal hormones, increased food intake, and increased hypothalamic neuropeptide Y expression. In contrast, none of these indices differed between NC-HE and NC-NC mice. Spearman correlation analysis revealed a significant correlation between the altered gut microbiota composition and the insulin resistance-related metabolic indicators, indicating involvement of the microbiota-gut-brain axis.DiscussionOur findings suggest that alterations in the early growth environment may prevent fetal-programmed glucose metabolic disorder via modulation of the microbiota-gut-brain axis. These findings offer direction for development of translational solutions for adult diseases associated with aberrant microbial communities in early life.

show abstract

“…siblings [39], or due to an effect on the airway microbiota [40], which may in turn influence infection susceptibility [41].…”

Section: Plos Onementioning

confidence: 99%

Middle ear effusion, ventilation tubes and neurological development in childhood

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Otitis media with middle ear effusion (MEE) can be treated with ventilation tubes (VT) insertion, and it has been speculated that prolonged MEE in childhood can affect neurological development, which in turn may be important for later academic achievements. Objective To investigate the association between middle ear effusion (MEE), treatment with ventilation tubes (VT) and childhood neurological development. Study design We examined 663 children from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) unselected mother-child cohort study. Children were followed by study pediatricians with regular visits from pregnancy until 3 years of age. MEE was diagnosed using tympanometry at age 1, 2 and 3 years. Information regarding VT from age 0–3 years was obtained from national registries. We assessed age at achievement of gross motor milestones from birth, language scores at 1 and 2 years, cognitive score at 2.5 years and general development score at age 3 years using standardized quantitative tests. Results Children with MEE had a lower 1-year word production vs. children with no disease: (median 2, IQR [0–6] vs. 4, IQR [1–7]; p = 0.017), and a lower 1-year word comprehension (median 36; IQR [21–63] vs. 47, IQR [27–84]; p = 0.03). Children with VT had a lower 2-5-year cognitive score vs. children with no disease; estimate -2.34; 95% CI [-4.56;-0.12]; p = 0.039. No differences were found between children with vs. without middle ear disease regarding age at achievement of gross motor milestones, word production at 2 years or the general developmental score at 3 years. Conclusion Our study supports the previous findings of an association between MEE and concurrent early language development, but not later neurological endpoints up to the age of 3. As VT can be a treatment of those with symptoms of delayed development, we cannot conclude whether treatment with VT had positive or negative effects on neurodevelopment.

show abstract

The developing airway and gut microbiota in early life is influenced by age of older siblings

Cited by 28 publications

References 52 publications

The influence of early life exposures on the infant gut virome

The influence of early life exposures on the infant gut virome

Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance via modulation of the microbiota-gut-brain axis

Middle ear effusion, ventilation tubes and neurological development in childhood

Contact Info

Product

Resources

About