The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
Amanda K. Riley,
Michael Grant,
Aidan Snell
et al.
Abstract:SUMMARYRIT1is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be tightly regulated by nucleotide exchange or hydrolysis. Instead, there is a growing understanding that the protein abundance of RIT1 is important for its regulation and function. We previously identified the deubiquitinaseUSP9Xas a RIT1 dependency inRIT1-mutant cells. Here, we demonstrate that both wild-type and mutant forms of RIT… Show more
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