The detrimental effects of iron to the joint; aggravation by inflammation

Vulpen, Lize F D van; Bergen, Eline D P van; Pulles, Astrid E; Mastbergen, S.C.

doi:10.1111/hae.14696

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The ADDIE model was used as the guiding framework for instructional design. The ADDIE model is a process used by instructional designers to help provide a framework for creating effective learning activities (van Vulpen, 2022). ADDIE is an acronym for the five phases of the model: analysis, design, development, implementation, and evaluation.…”

Section: Strategymentioning

confidence: 99%

“Lounge & Learns”

Boespflug¹

2022

J Nurses Prof Dev

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What if you could increase learner engagement while providing data-driven education in a virtual format? Nursing professional development practitioners transitioned poorly attended, in-person continuing education opportunities to a virtual platform. Using technology, nursing professional development practitioners created a template to perform a needs assessment and designed targeted virtual education to address deficiencies using the ADDIE model. Increased attendance, continuing education credit claims, and postactivity confidence were realized. Lessons learned were examined.

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Section: Strategymentioning

confidence: 99%

“Lounge & Learns”

Boespflug¹

2022

J Nurses Prof Dev

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“…Iron has a pivotal role in the pathogenesis of HA [12][13][14]. Upon a joint bleed, hemederived iron accumulates as hemosiderin within the synovium, where it induces inflammation and cell proliferation, causing chronic synovitis and synovial hyperplasia [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Towards Personalized Treatment in Haemophilia: The Role of Genetic Factors in Iron and Heme Control to Identify Patients at Risk for Haemophilic Arthropathy

van Vulpen,

Mastbergen,

Foppen

et al. 2024

JPM

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The treatment landscape for haemophilia is changing rapidly, creating opportunities for personalized treatment. As major morbidity is still caused by haemophilic arthropathy, understanding the factors affecting joint damage and joint damage progression might lead to more individualized treatment regimens. We investigated the association of HFE mutations or HMOX1 polymorphisms affecting iron/heme handling with radiographic joint damage in 252 haemophilia patients (severe and moderate). Although iron levels and transferrin saturation were significantly increased in the 95 patients with an HFE mutation, neither carrying this mutation nor the HMOX1 polymorphism was associated with radiographic joint damage, and the same was true after adjustment for well-known factors associated with arthropathy. In conclusion, this study does not support the hypothesis that HFE mutations or HMOX1 polymorphisms can be used to predict the development of haemophilic arthropathy.

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A commentary on “maladaptive lymphangiogenesis” according to Newton’s third law: the law of action and reaction as it applies to joint bleeding

Valentino

2023

Journal of Thrombosis and Haemostasis

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The detrimental effects of iron to the joint; aggravation by inflammation

Cited by 3 publications

References 10 publications

“Lounge & Learns”

“Lounge & Learns”

Towards Personalized Treatment in Haemophilia: The Role of Genetic Factors in Iron and Heme Control to Identify Patients at Risk for Haemophilic Arthropathy

A commentary on “maladaptive lymphangiogenesis” according to Newton’s third law: the law of action and reaction as it applies to joint bleeding

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