The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials

Nune, K. C.; Montes, Ivan; Injeti, V.S.Y.; Somani, Mahesh C.; Misra, R.D.K.

doi:10.1016/j.jmbbm.2018.08.033

Cited by 10 publications

(10 citation statements)

References 59 publications

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“…However, the present ultrafine‐grained (UFG) steels differ from other UFG alloys processed by severe plastic deformation by remarkable plasticity with total elongation above 15%. Sufficient ductility has been considered as an important property of the biomedical devices (Nune et al, ). The beneficial strength–ductility combination in the present UFG steels resulted from elevated temperature of ECAP that enhanced recovery of the work‐hardened dislocation substructures during processing and retained the ability of the steels to mechanical twinning as seen in Figure .…”

Section: Discussionmentioning

confidence: 99%

“…The work (Misra et al, ; Misra et al, ) confirms that cell attachment, proliferation, viability, morphology, and spread on a substrate made of 316L steel with a UFG structure obtained by cold rolling and subsequent annealing are favorably modulated and significantly vary from the cell behavior on steel substrates in a coarse‐grained condition. The difference in the behavior of cells is explained in the work (Misra et al, ; Misra et al, ; Nune, Montes, Injeti, Somani, & Misra, ) by the grain size and the degree of hydrophilicity of the steels. The research of 316L stainless steel (Muley, Vidvans, Chaudhari, & Udainiya, ) with ultrafine grained structure obtained by multiaxial forging with an average grain size of 0.86 μm after nine strain steps revealed improved sliding wear resistance and enhanced pitting resistance of forged steel.…”

Section: Introductionmentioning

confidence: 99%

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The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

et al. 2019

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In this study, equal‐channel angular pressing (ECAP) of austenitic 316L and Cr–Ni–Ti stainless steels was carried out. Effect of ECAP at 400°C on the evolution of the microstructure, mechanical properties, and biocompatibility of these steels was investigated. The biocompatibility of samples with the ultrafine grain structure obtained in the ECAP process did not deteriorate in comparison with an austenitic 316L stainless steel in coarse‐grained state. However, this treatment enhances the multipotent mesenchymal stromal/stem cell proliferation by 26% for 316L steel and by 17% for Cr–Ni–Ti stainless steel in comparison with coarse‐grained counterparts. At the same time, ECAP contributes to a significant improvement in performance and weight reduction of medical devices, which is especially important for the creation of implanted prostheses for replacement of skeletal defects, due to significant increase in specific strength of steels. The strength properties of austenitic stainless steels were remarkably improved due to the grain refinement and deformation twinning resulted from ECAP at 400°C. After ECAP, the yield strength of 316L and Cr–Ni–Ti stainless steels increased by 4.2 and 2.9 times up to 950 and 900 MPa, and the fatigue limit by 2 and 1.7 times up to 500 and 475 MPa, respectively, comparing to coarse‐grained counterparts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

et al. 2019

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“…Metallic materials have been used as artificial substitutes, fixture apparatus or therapeutic appliance in numerous biomedical applications, such as hip replacements in orthopedics, stents in cardiovascular surgery, or archwires in orthodontics [1][2][3]. Austenitic stainless steel has been one of the most widely used alloys among metallic biomaterials because of its good corrosion resistance, biocompatibility, availability and ease of formability [1][2][3]. Moreover, it has good mechanical strength and ductility, owing to distinctive hardening response ascribed to activation of deformation twinning, which stems from low stacking fault energy (SFE) [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Activation of either of these mechanisms depends strongly on grain size [6,8]. Interestingly, martensite is induced primarily on the samples having coarse grains and deformation twinning becomes the governing mechanism as the grains get finer [3]. Furthermore, martensite transformation can depend on SFE, such that SFE lower than 18 mJm −2 favors direct transformation of γ-austenite (fcc) → ε-martensite (hcp) → α'-martensite (bcc) [11].…”

Section: Introductionmentioning

confidence: 99%

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In vitro contact guidance of glioblastoma cells on metallic biomaterials

Uzer-Yilmaz

2021

J Mater Sci: Mater Med

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Cancer cells’ ability to sense their microenvironment and interpret these signals for the regulation of directional adhesion plays crucial role in cancer invasion. Furthermore, given the established influence of mechanical properties of the substrate on cell behavior, the present study aims to elucidate the relationship between the contact guidance of glioblastoma cell (GBM) and evolution of microstructural and mechanical properties of the implants. SEM analyses of the specimens subjected to 5 and 25% of plastic strains revealed directional groove-like structures in micro and submicro-sizes, respectively. Microscale cytoplasmic protrusions of GBMs showed elongation favored along the grooves created via deformation markings on 5% deformed sample. Whereas filopodia, submicro-sized protrusions facilitating cancer invasion, elongated in the direction perpendicular to the deformation markings on the 25% deformed sample, which might lead to easy and rapid retraction. Furthermore, number of cell attachment was 1.7-fold greater on 25% deformed sample, where these cells showed the greatest cellular aspect ratio. The directional attachment and contact guidance of GBMs was reported for the first time on metallic implants and these findings propose the idea that GBM response could be regulated by controlling the spacing of the deformation markings, namely the degree of plastic deformation. These findings can be applied in the design of cell-instructive implants for therapeutic purposes to suppress cancer dissemination.

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Mechanical performance of metallic biomaterials

Uzer-Yilmaz

2024

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

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The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials

Cited by 10 publications

References 59 publications

The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

The influence of ultrafine‐grained structure on the mechanical properties and biocompatibility of austenitic stainless steels

In vitro contact guidance of glioblastoma cells on metallic biomaterials

Mechanical performance of metallic biomaterials

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