The Determination of the Structure of Rotenone.

Forge, F. B. La; Haller, H. L.; Smith, L. E.

doi:10.1021/cr60042a001

Cited by 51 publications

(20 citation statements)

References 29 publications

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“…In 1902, Japanese chemist Nagai Nagayoshi isolated a pure crystalline compound from Derris elliptica and he called it rotenone. Nicouline and rotenone were recognized to be chemically the same by 1930 [39]. Since 1932, rotenone has been used extensively in fisheries management as a piscicide in North America.…”

Section: Historical Backgroundmentioning

confidence: 99%

Rotenone: from modelling to implication in Parkinson’s disease

Radad

Al‐Shraim

Al-Emam

et al. 2019

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Rotenone ([2R-(2α,6aα,12aα)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyran[3,4-b]furo [2,3-h][1]benzopyran-6(6aH)-one) is a naturally occurring compound derived from the roots and stems of Derris, Tephrosia, Lonchocarpus and Mundulea plant species. Since its discovery at the end of the 19 th century, rotenone has been widely used as a pesticide for controlling insects, ticks and lice, and as a piscicide for management of nuisance fish in lakes and reservoirs. In 2000, Betarbet et al. reproduced most of the behavioural, biochemical and pathological features of Parkinson's disease (PD) in rotenone-treated rats. Since that time, rotenone has received much attention as it would be one of the environmental neurotoxins implicated in etiopathogenesis of PD. Moreover, it represents a common experimental model to investigate the underlying mechanisms leading to PD and evaluate the new potential therapies for the disease. In the current general review, we aimed to address recent advances in the hazards of the environmental applications of rotenone and discuss the updates on the rotenone model of PD and whether it is implicated in the etiopathogenesis of the disease.

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Section: Historical Backgroundmentioning

confidence: 99%

Rotenone: from modelling to implication in Parkinson’s disease

Radad

Al‐Shraim

Al-Emam

et al. 2019

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“…Japanese word -roten‖. Because of the discoveries, the nicouline and rotenone were finally established to be useful in farming by 1930 (La Forge et al, 1933). The government agencies of the United States used already the tubli as a source of rotenone for many purposes in fishing and farming (Tanner et al, 2011;Schmidt, 2014;Daroff and aminoff, 2014).…”

Section: Rotenonementioning

confidence: 99%

A Review on Tubli Plant used as Organic Pesticide: Input toward Sustainable Agriculture

Biñas

2021

Int. j. res. appl. sci. biotechnol.

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The use of a botanical pesticide like tubli plant crude extracts is one of the practical methods for those farmers who are not capable to incur the expensive commercial pesticides. This contributes to the sustainability of agriculture because it has no adverse effects on the environment. This review article introduces the characteristics of tubli plant and assesses its efficacy as an organic pesticide. The most strong and effective pesticidal property of tubli plant is rotenone which controlled various pests. This had been cultivated and used as an organic pesticide all over the world. Some studies revealed that the application of tubli plants enhanced farmers’ productivity of farms and the profitability of their income. Tubli plant is adapted to be one of the inputs toward sustainable agriculture.

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“…In 1985, Emmanuel Geoffrey discovered a compound in Lonchocarpus nicou, Nicouline (see Ambrose and Haag, 1936). Later, Nagai Nagayoshi isolated ''rotenone'' from Derris elliptica (see Laforge et al, 1933). Although the two compounds are identical, the name given by the Japanese chemist prevailed.…”

Section: Influence Of Pesticides and Related Environmental Toxics In mentioning

confidence: 99%

Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease

Franco

Rivas‐Santisteban

Reyes‐Resina

et al. 2020

Front. Aging Neurosci.

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The exact cause of Parkinson's disease (PD), the second most prevalent neurodegenerative disease in modern societies, is still unknown. Many scientists point out that PD is caused by a complex interaction between different factors. Although the main risk factor is age, there are other influences, genetic and environmental, that individually or in combination may trigger neurodegenerative changes leading to PD. Nowadays, research remains focused on better understanding which environmental factors are related to the risk of developing PD and why. In line with the knowledge on evidence on exposures that prevent/delay PD onset or that impact on disease progression, the aims of this review were: (i) to comment on the non-genetic risk factors that mainly affect idiopathic PD; and (ii) to comment on seemingly reliable preventive interventions. We discuss both environmental factors that may affect the central nervous system (CNS) or the intestinal tract, and the likely mechanisms underlying noxious or protective actions. Knowledge on risk, protective factors, and mechanisms may help to envisage why nigral dopaminergic neurons are so vulnerable in PD and, eventually, to design new strategies for PD prevention and/or anti-PD therapy. This article reviews the variety of the known and suspected environmental factors, such as lifestyle, gut microbiota or pesticide exposition, and distinguishes between those that are harmful or beneficial for the PD acquisition or progression. In fact, the review covers one of the most novel players in the whole picture, and we address the role of microbiota on keeping a healthy CNS and/or on preventing the "side-effects" related to aging.

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The Determination of the Structure of Rotenone.

Cited by 51 publications

References 29 publications

Rotenone: from modelling to implication in Parkinson’s disease

Rotenone: from modelling to implication in Parkinson’s disease

A Review on Tubli Plant used as Organic Pesticide: Input toward Sustainable Agriculture

Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease

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