The determination of stability constants of N-acetyl-l-cysteine chrome, nickel, cobalt and iron complexes by potentiometric method

Güzeloğlu, Ş.; Yalçın, Güler; Pekin, Mürşit

doi:10.1016/s0022-328x(98)00719-0

Cited by 14 publications

(19 citation statements)

References 7 publications

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“…[22][23][24] As can be observed (Figure 4, curves b) the analytical signal increases by increasing HCl concentration in the carrier solution for NAC which was explained by Fe 3+ displacement from complex in higher acidic media. However, the same displacement effect was not confirmed for CPT since small signals variation was observed by increasing HCl concentration in the carrier solution as well as the signals have decreased for higher acidic concentration.…”

Section: Optimization Of Flow Parametersmentioning

confidence: 96%

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Chagas¹,

Santos²,

Santos³

et al. 2009

J. Braz. Chem. Soc.

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em meio ácido. A ordem de adição de reagentes foi avaliada e os parâmetros analíticos foram otimizados. As faixas lineares de concentração foram de 2,5-90 e de 5,0-50 mg L -1 para CPT e NAC, respectivamente. Os limites de detecção (3σ) foram calculados em 0,22 e 1,8 mg L -1 e desvios padrão relativos (N = 10) foram inferiores que 1,0 e 2,1% para CPT e NAC, respectivamente. O procedimento foi empregado para a determinação de CPT e NAC em diversas formulações farmacêuticas e os resultados concordaram com os obtidos pelos métodos de referência para 95% de confiabilidade aplicando teste-t pareado.A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L -1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L -1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.

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Section: Optimization Of Flow Parametersmentioning

confidence: 96%

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Chagas¹,

Santos²,

Santos³

et al. 2009

J. Braz. Chem. Soc.

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“…21,22) . 22,24,25) The mixed ligand combination of acetylcysteine and ligands C or D is expected to improve the stability of the chelate complex.…”

Section: )mentioning

confidence: 99%

“…21,22) . 22,24,25) The mixed ligand combination of acetylcysteine and ligands C or D is expected to improve the stability of the chelate complex.Recently, the complexation of ligands C and D with metal ion has gained attention of some researchers. [26][27][28][29][30] To the best of our knowledge, very few literatures are available for the complexation study of ligand D with essential divalent metal ions.…”

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confidence: 99%

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Solution Equilibrium Study of Divalent Metal Ions with Phenylpropanoid Derivatives and Acetylcysteine Ligands

Nguyen

Santoso

Nguyen

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Solution equilibrium of divalent metal ions (M Mn21) Redox-inert metals such as mercury (Hg), lead (Pb) and cadmium (Cd) are toxic agents, exposure to these and other essential metals may cause negative effects on health.2) Metals are known to be able to bind with proteins in human body which may lead to various detrimental effects on human health. For instance, high exposure of zinc results in respiratory and gastrointestinal toxicity, clinical changes and copper deficiency.3) Excess amount of copper can cause serious diseases including cancers, liver and kidney damage.4) Cobalt exposure leads to ailment such as vision problem, lung problem, heart problem and thyroid damage. Exposure to manganese can cause disorders such as Parkinson, schizophrenia and dullness. Although nickel appears to be essential for plants and bacteria, however for human this metal was found to be difficult to elucidate and may cause severe health problems such as cancer. 5)Chelation therapy is known as an effective treatment to reduce the harmful effects of metal ions by utilizing the metal binding ability of organic ligand.6-10) Therefore to prevent metal intoxication, the ligand used should have stronger binding ability than the proteins. Phenylpropanoid derivatives, currently considered as promising chelating agents, are classified as phenolic acids that are known to function as natural antioxidant, free radical scavenger, anti-carcinogenic, and chemoprevention agent. [11][12][13][14] In this work, caffeic acid and dihydrocaffeic acid were chosen as the phenylpropanoid derivatives. Caffeic acid (denoted as ligand C) is an important anti-oxidative compound which can be extracted from natural sources such as coffee bean, potatoes, grains and vegetables. 15)This compound has beneficial pharmacological effects such as inhibit cancer cell in human HT-1080 fibro sarcoma cell line. 16,17) Dihydrocaffeic acid (denoted as ligand D) is a degradation product of caffeic acid, this compound is one of the critical phenolic antioxidants commonly present in olives, 18) and in blood or urine as the result of secondary metabolism of various polyphenols.19) The ortho-dihydroxyl structure of ligand D is also known to act as an active radical-scavenger. 15)On the other hand, acetylcysteine is an organic compound which has been approved as one of the essential medicines for basic health system by World Health Organization (WHO). 20)Acetylcysteine is known as a precursor for glutathione, the antioxidant which prevents formation of oxidative species in tissue. 21,22) . 22,24,25) The mixed ligand combination of acetylcysteine and ligands C or D is expected to improve the stability of the chelate complex.Recently, the complexation of ligands C and D with metal ion has gained attention of some researchers. [26][27][28][29][30] To the best of our knowledge, very few literatures are available for the complexation study of ligand D with essential divalent metal ions. Therefore, in order to gain primary understanding on the complexation of ligands C and D, potenti...

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“…Therefore, PA removed Au 3+ from PDPMT-Cl leading the recovery of PDPMT-Cl fluorescence. The stability constants of PAAu 3+ and Au 3+ -PDPMT-Cl were determined by potentiometric titration technique [39][40][41][42]. The stability constants of PA-Au 3+ and Au 3+ -PDPMT-Cl were 10 17.62 and 10 7.21 , indicating that PA was a stronger chelator than PDPMT-Cl to form complexes with Au 3+ .…”

Section: Performance Evaluation On Pdpmt-cl Fluorescence "Off-on" Swimentioning

confidence: 99%

The development of a conjugated polyelectrolytes derivative based fluorescence switch and its application in penicillamine detection

Zhai

Zhuang

Pei

et al. 2015

Journal of Molecular Liquids

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The determination of stability constants of N-acetyl-l-cysteine chrome, nickel, cobalt and iron complexes by potentiometric method

Cited by 14 publications

References 7 publications

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Solution Equilibrium Study of Divalent Metal Ions with Phenylpropanoid Derivatives and Acetylcysteine Ligands

The development of a conjugated polyelectrolytes derivative based fluorescence switch and its application in penicillamine detection

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