The determination of radiobiologically optimized half-lives for radionuclides used in permanent brachytherapy implants

Armpilia, Christina; Dale, Roger G.; Coles, Ian; Jones, Bleddyn; Antipas, V.P.

doi:10.1016/s0360-3016(02)04208-6

Cited by 73 publications

(62 citation statements)

References 24 publications

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“…The dosimetric characteristics of 131 Cs seeds are similar to those of 125 I and 103 Pd seeds, with the exception that 131 Cs seeds have a short half-life of 9.7 days (4,5). Many studies have suggested that shorter-halflife radioactive seeds offer better tumor control than longerhalf-life radioactive seeds (6,7).…”

Section: Introductionmentioning

confidence: 84%

“…Treatment delivery times with these implants are theoretically infinite, and sublethal damage repair and tumor cell repopulation occur simultaneously. Therefore, during dose delivery, the survival fraction (SF) of the tumor cells (6,7,9,(21)(22)(23) can be given by…”

Section: Biological Modelmentioning

confidence: 99%

“…Published reports of 125 I and 103 Pd prostate implants are based on an evaluation of preimplant volumes or postimplant volumes of the prostate obtained after 1 month of implantation (2,(6)(7)(8). The effect of prostatic edema on dosimetric quantities has been studied by many investigators (9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Kehwar

Jones

Huq

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 84%

Section: Biological Modelmentioning

confidence: 99%

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Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Kehwar

Jones

Huq

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…Armpilia et al (29) have used a linear-quadratic model suitable for the analysis of permanent brachytherapy implants to investigate the radionuclide half-lives that will maximize the BED delivered to tumors. Their conclusion is that ''for a wide range of tumor types, shorter-lived radionuclides are more versatile for achieving reasonable clinical results.''…”

Section: Discussionmentioning

confidence: 99%

Moving Toward Focal Therapy in Prostate Cancer: Dual-Isotope Permanent Seed Implants as a Possible Solution

Todor

Barani

Lin

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…A potential doubling time (T pot ) of 42 days was used in this analysis resulting in a repopulation factor K of 0.11 Gy × day-1 [12, 14]. …”

Section: Methodsmentioning

confidence: 99%

Clinical Investigations Radiobiologically based treatment plan evaluation for prostate seed implants

Knaup

Mavroidis

Esquivel

et al. 2011

jcb

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PurposeAccurate prostate low dose-rate brachytherapy treatment plan evaluation is important for future care decisions. Presently, an evaluation is based on dosimetric quantifiers for the tumor and organs at risk. However, these do not account for effects of varying dose-rate, tumor repopulation and other biological effects. In this work, incorporation of the biological response is used to obtain more clinically relevant treatment plan evaluation.Material and methodsEleven patients were evaluated. Each patient received a 145 Gy implant. Iodine-125 seeds were used and the treatment plans were created on the Prowess system. Based on CT images the post-implant plan was created. In the post-plan, the tumor, urethra, bladder and rectum were contoured. The biologically effective dose was used to determine the tumor control probability and the normal tissue complication probabilities for the urethra, bladder, rectum and surrounding tissue.ResultsThe average tumor control probability and complication probabilities for the urethra, bladder, rectum and surrounding tissue were 99%, 29%, 0%, 12% and 6%, respectively. These measures provide a simpler means for evaluation and since they include radiobiological factors, they provide more reliable estimation of the treatment outcome. ConclusionsThe goal of this work was to create more clinically relevant prostate seed-implant evaluation by incorporating radiobiological measures. This resulted in a simpler descriptor of treatment plan quality and was consistent with patient outcomes.

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The determination of radiobiologically optimized half-lives for radionuclides used in permanent brachytherapy implants

Cited by 73 publications

References 24 publications

Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Moving Toward Focal Therapy in Prostate Cancer: Dual-Isotope Permanent Seed Implants as a Possible Solution

Clinical Investigations Radiobiologically based treatment plan evaluation for prostate seed implants

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