The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection

Abstract

These findings prove the predictive sensitivity of GGT as an independent indicator of nonresponsiveness even at levels that are slightly above the normal range. This new predictive parameter may help to improve individualized therapy in HCV type-1 infection.

Efficacy of Treatment With Pegylated Interferon and Ribavirin in Patients With Chronic HCV Infection “Under Real Life“ Conditions

“…Several investigators reported that increased γGT activity strongly associates with primary antiviral treatment failure [21,64,[67][68][69]. Weak trend of inverse SVR correlation with γGT activity was found in our study by univariate analysis too [OR 2.242 (0.956-5.259), p-0,063], but it was not confirmed by multivariate analysis.…”

Predictors of treatment response in patients with hepatitis C 1b genotype

“…Absence of association of gender and BMI with treatment outcomes was also shown in several large prospective studies [11,12,24]. It is also worth noting, that although 61% of our patients were overweight (BMI > 25 kg/m with other studies [17,33], which rendered differences statistically non-significant. Therefore, we agree with Navaneethan et al [35] in that the use of the above pre-treatment factors cannot accurately predict SVR in all patients.…”

“…Moreover, previous studies have shown that younger age (< 40 years), normal GGT level, high ALT level, normal platelet count, absence of cirrhosis, low viral load, virus genotype and Caucasian race were more probably associated with better treatment outcomes [11][12][13][14]17,33]. Also, as suggested by Marcellin et al [34], referring to the PROPHESYS database, a simple scoring system including such factors as age, BMI, viral load, platelet count, ALT level and ALT/AST ratio can help identify HCV-1b patients who can benefit from therapy with pegylated interferon and ribavirin.…”

High Predictability of a Sustained Virological Response (87%) in Chronic Hepatitis C Virus Genotype 1 Infection Treatment by Combined IL28B Genotype Analysis and &#947;-Glutamyltransferase/Alanine Aminotransferase Ratio: A Retrospective Single-Center Study

“…Laboratory parameters such as the level of ALT and γ-GT are associated with treatment outcome after antiviral therapy irrespective of receiving either dual or triple therapy combinations [7,11,12,13,16]. None of these studies, however, reported a cutoff value for these two laboratory factors that define a successful treatment outcome.…”

“…In two prospective trials, serum ALT activity was not related to SVR. In contrast, in retrospective studies using multivariate multinomial logistic regression analysis, high ALT activity was associated with treatment outcome [7,11,12]. In addition, low pretreatment serum γ-glutamyltransferase (γ-GT) activity was found to be significantly and independently related to SVR in multivariate regression analyses [12,13].…”