The Determination of Cardiac Output by a Continuous Recording System Utilizing Iodinated (I ¹³¹ ) Human Serum Albumin

Abstract

A method is outlined for the determination of cardiac output by the injection of iodinated ('131) human serum albumin and continuous recording of the dilution curve. The calibration of the flow system by means of the final dilution and blood volume is discussed along with the possible application to an external measuring method. The results of eight dilution curves obtained from dogs are presented and the calculated cardiac outputs compared with the values measured by the rotameter method.

Acute and Chronic Cardiovascular Effects of Pentolinium in Hypertensive Patients

“…Blood was shifted from the pulmonary to the peripheral circulation. Continued effective oral treatment with this agent over a period of 6 Two patients are described in whom cardiovascular manifestations accompanied metastasizing carcinoid. In 1, a 53-year-old man, diarrhea, "asthma," flushing attacks, and congestive heart failure accompanied biopsy-proven hepatic metastases whose origin was not identified.…”

Measurement of Hepatic Blood Flow by Indicator Dilution Techniques12

“…per second). The change in concentration of radioactivity as a function of time during the primary circulation was recorded on a semilogarithmic graphic ammeter 6 which received the count rate computer output (11) (Figure 1). The final 10 minute equilibrium of circulating isotope was measured in the direct recording system and then a 1 ml.…”

“…The probe was left exactly in the same place over the liver; final dilution of isotope was measured at 10 minutes in the same vascular pool sampled by the probe during dilution. Finally radioactivity was measured over the subapical retermined rates and can respond as often as every second (11). 6 Esterline Angus Co., Indianapolis, Ind., or Varian (G-11 Recorder), Palo Alto, Cal.…”

The Determination of Cardiac Output by the Dilution Method without Arterial Sampling

“…A LTHOUGH earlier determinations of 14A cardiac output in this laboratory [1][2][3] by the radioisotope dilution method were performed by isolating the flow from a specific artery, such sampling is not required by the general formulation of the method. Since the obviation of the arterial puncture would considerably simplify this measurement clinically, studies have been extended 4-to determine cardiac output by focusing a gamma ray detector externally over the region of the cardiac chambers or great vessels.…”