The Determination of Blood Viscosity in Man by a Method Based on Poiseuille's Law

Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis

“…The sparse sampling design, limited number of blood samples in the absorption phase, and relatively low number of patients may have affected the estimations of the inter-individual variabilities of the parameters. In the current study, the RBC value was excluded from the final model, although its influence on the distribution of iloperidone may not be negligible because the number of RBCs can affect the hematocrit value (ie, the primary determinant of the blood viscosity) and hence the drug plasma protein-binding rate [24] .…”

“…We set CYP2D6*10 C/C (ie, the wild-type homozygote), C/T (ie, the heterozygote), and T/T (ie, the mutant homozygote) as 1, 2, and 3, respectively. TV (K 24 ) is the typical K 24 value in patients with the CYP2D6*10 C/C genotype; K 24 in patients with the CYP2D6*10 C/T genotype was θ 1 *TV(K 24 ), and this value in patients with the CYP2D6*10 T/T genotype was θ 2 *TV(K 24 ).…”

“…In the forward model building step, the CYP2D6*10 and RBC parameters decreased the OFV by more than 3.84 or 5.99 (P<0.05) at each addition. The CYP2D6*10 mutation significantly affected the K 23 and K 24 . The RBC influenced the volume of iloperidone.…”

The influence of acidity on hematocrit and hemoglobin values in newborn infants immediately after delivery

“…Hemoconcentration, caused by enlarged capillary leakage and enhanced passage of blood fluid into the exträväsculär space, results in a diminution of the blood volume which in turn may negatively affect pressure and blood flow in the circulatory System. In addition, hemoconcentration is inevitably ässociated* with an elevation of blood viscosity; an increase in hematocrit from 50 to 60 per cetit, for instance, is equivalent to a rise in blood viscosity of approximately l centipoise [4]. Logically, both maüifestations, namely reduction of the circulating blood volume and rise in blood viscosity, will .certainly not improve the surviväl chances of an acidotic infant born in a depressed condition.…”

Rheology of Human Blood. Studies on the Flow of Fresh Venous Blood and of Citrated Blood Through Tubing of Diameters Between 0.09 and 0.20 Cm

“…Investigative work on blood is complicated by the finding that the very removal of blood from the vascular system is associated with changes in Theological properties (1,(15)(16)(17). These changes may be related to factors, including the nature of the boundary surface (18)-modification of plasma-cellular interactions that result from addition of anticoagulants (1,12,19), differences in oxygen-carbon dioxide content (16,20,21), defibrination (15), differences in temperature (9), or surface denaturation of cellular or plasma proteins-or they may be related to structural damage of the cells and other processes that result from the storage of blood (9,12,19).…”