The determination of benzalkonium chloride in eye-drops by difference spectrophotometry

Kovacs-Hadady, K.; Fábián, István

doi:10.1016/s0731-7085(97)00085-x

Cited by 20 publications

(9 citation statements)

References 8 publications

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“…Some analytical procedures have been reported for the assay of benzalkonium chloride, such as the potassium iodate titration method [1], the spectrophotometric method [2][3][4][5], the flow injection analytical method [6], the capillary zone electrophoresis method [7,8], the gas chromatographic method [9,10], and the high performance liquid chromatographic method [11][12][13][14]. In contrast, spectrophotometric methods utilise inexpensive instruments and simple operational procedures and allow rapid determination.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, spectrophotometric methods utilise inexpensive instruments and simple operational procedures and allow rapid determination. Thus, spectrophotometric methods are widely used for the determination of benzalkonium chloride [2][3][4][5]. Potassium iodate titration [1] needs the use of toxic chloroform, Masahiro Tsubouchi [2] reported the solvent extraction spectrophotometric determination of benzalkonium chloride based on solvent extraction of an ion-pair formed between benzalkonium chloride and anionic dye tetrabromophenolphthalein ethyl ester.…”

Section: Introductionmentioning

confidence: 99%

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Two Spectrophotometric Methods for the Assay of Benzalkonium Chloride in Bandage Samples

Wei-xing

Sha

et al. 2013

J Surfact & Detergents

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Two rapid, direct, extraction-free spectrophotometric procedures were developed for the determination of benzalkonium chloride. The procedures were based on the formation of mixed dye-surfactant aggregates between eosine Y and benzalkonium chloride (Method A), or between eosine B and benzalkonium chloride (Method B) in Clark-Lubs medium by measuring the increase in absorbance at 556 and 550 nm, respectively. Beer's law was obeyed in the concentration range of 0.5-12 and 0.5-12 lg mL -1 for benzalkonium chloride with good precision and accuracy, whose limits of detection were 0.1 lg mL -1 at 556 nm for Method A and 0.2 lg mL -1 at 550 nm for Method B, respectively. The proposed procedures were successfully applied to the assay of benzalkonium chloride in bandages. The analytical results of the real samples were in good agreement with those by HPLC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two Spectrophotometric Methods for the Assay of Benzalkonium Chloride in Bandage Samples

Wei-xing

Sha

et al. 2013

J Surfact & Detergents

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“…Additionally, incomplete extraction of the analyte may lead to erratic results. In an attempt to overcome these shortcomings associated with extractive spectrophotometric methods, several workers in recent years have devised extraction-free spectrophotometric methods for several pharmaceutical substances [38][39][40][41][42][43][44][45] based on ion-pair reaction and employing some sulfonphthalein dyes. These new procedures are free from critical pH adjustment and laborious liquid-liquid extraction step and involve simple mixing the drug and dye solutions in organic solvent and measuring the absorbance of the resulting ion-pair complex at wavelength of maximum absorption.…”

Section: Introductionmentioning

confidence: 99%

Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Swamy

Basavaiah

2013

ISRN Analytical Chemistry

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Albendazole (ALB) is a potent benzimidazole anthelmintic used in the treatment of human intestinal helmintiasis as well as of hytatid cysts and neurocysticercosis. Two rapid, simple, sensitive, and selective spectrophotometric methods are presented for the determination of ALB in pharmaceuticals. The methods are based on the formation of dichloromethane soluble 1 : 1 ion-pair complexes (ALB : dye) formed between ALB and sulfonphthalein dyes, bromophenol blue BPB, (method A) and bromothymol blue BTB, (method B). The complexes formed were measured directly (without extraction) at 445 nm (method A) and 460 nm (method B). The experimental conditions were optimized and the systems obey Beer’s law for 1.5–21.0 and 2.0–32.0 μg mL−1 ALB for method A and method B respectively. The molar absorptivity and Sandell's sensitivity were calculated to be L mol−1 cm−1 and 0.0209 ng cm−2, and L mol−1 cm−1 and 0.0350 ng cm−2 using BPB and BTB, respectively. The limits of detection and quantification were calculated to be 0.01 and 0.03, and 0.16, and 0.49 μg mL−1 using BPB and BTB, respectively. The relative standard values for intra-day and inter-day precision were less than 3%, and the accuracy was better than 3% for both methods.

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“…A variety of methods including liquid chromatography (LC) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], immunoassays [19][20][21][22][23][24], microbiological assays [25], spectrophotometry [26,27] and capillary zone electrophoresis (CE) [28,29] have been introduced for the measurement of TOB in pharmaceutical preparations and biological matrices. Among these methods, LC and immunoassays are preferred.…”

Section: Introductionmentioning

confidence: 99%

Adsorptive stripping voltammetric technique for the rapid determination of tobramycin on the hanging mercury electrode

Sun

Shen

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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The determination of benzalkonium chloride in eye-drops by difference spectrophotometry

Cited by 20 publications

References 8 publications

Two Spectrophotometric Methods for the Assay of Benzalkonium Chloride in Bandage Samples

Two Spectrophotometric Methods for the Assay of Benzalkonium Chloride in Bandage Samples

Use of Two Sulfonphthalein Dyes for the Sensitive and Selective Extraction-Free Spectrophotometric Assay of Albendazole in Bulk Drug and in Tablets

Adsorptive stripping voltammetric technique for the rapid determination of tobramycin on the hanging mercury electrode

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