The determination of a potential impurity in Thalidomide drug substance and product by HPLC with indirect UV detection

Thalidomide enantiomers: Determination in biological samples by HPLC and vancomycin-CSP

“…Samples need to be promptly cooled, acidified and stored at −20 • in order to avoid hydrolytic degradation of thalidomide [5][6][7][8][9][10][11][12][13][14]. The method developed was simple, with good precision and accuracy.…”

“…Many methods have been developed to quantify thalidomide and its metabolites from a variety of biological matrices [7][8][9][10][11][12][13][14][15][16][17]. Most of these methods are achiral, being based on HPLC using reverse phase separation with UV, MS (mass spectrometry) or tandem MS detection.…”

Comparison of the predictive ability of several second-order multivariate methods in the simultaneous determination of two therapeutic drugs in human urine

“…Also, thalidomide is a synthetic derivative of glutamine and at physiologic pH can undergo hydrolysis to form this compound again. Li et al have been developed a HPLC method with indirect UV detection, for study the purity of thalidomide and determine glutamine in thalidomide drug substances and products [20].…”