The Determinants of the Quality of Life of Gastroesophageal Reflux Disease Patients Attending King Saud University Medical City

Alabdulkareem, Abdulaziz M; Aloqeely, Khaled M; Alhumud, Muath I; Alghufaily, Saud A; Al-Dossare, Yazeed I; Alrashdan, Naser O

doi:10.7759/cureus.9505

Cited by 12 publications

(14 citation statements)

References 23 publications

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“…Belching and gastroesophageal reflux disease (GERD) negatively impact the quality of life. [1][2][3][4] Previous studies in referral centers showed that almost half of patients with GERD had excessive belching as their main disturbing symptom, and supragastric belching (SGB) was demonstrated as the primary mechanism of belching in these patients. [5][6][7][8] An association between GERD and SGB has been suggested.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching

Keeratichananont

Patcharatrakul

Gonlachanvit

2023

J Neurogastroenterol Motil

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Background/AimsA high prevalence of GERD has been reported in patients with supragastric belching. We aim to evaluate reflux characteristics and explore the temporal relationship between supragastric belches (SGBs) and reflux episodes in GERD patients with excessive belching. MethodsTwenty-four hour esophageal pH-impedance monitoring was analyzed. Reflux episodes were classified into: refluxes preceded by SGBs, followed by SGBs, and lone refluxes. Reflux characteristics were compared between patients with pH-positive (pH+) and pH-negative (pH-). ResultsForty-six patients (34 Female, age 47 ± 13 years) were included. Fifteen patients (32.6%) had pH+. Almost half (48.1 ± 21.0%) of refluxes were preceded by SGBs. The number of SGBs significantly correlated with the number of reflux episodes preceded by SGBs (r = 0.43, P < 0.05) and % time pH < 4 at the distal esophagus (r = 0.41, P < 0.05). Patients with pH+ had significantly more SGBs and reflux episodes preceded by SGBs/day than pH-patients (P < 0.05). The difference in the number of refluxes between pH+ and pH-patients was caused by reflux episodes preceded by SGBs, but not lone refluxes and refluxes followed by SGBs. The proportion of SGBs followed by reflux/total SGBs was similar between patients with pH+ and pH-(P > 0.05). Reflux episodes preceded by SGBs and followed by SGBs extended more proximal and had longer bolus and acid contact time than lone refluxes (P < 0.05). ConclusionsIn patients with GERD and SGB, the number of SGBs positively correlates with the number of reflux episodes preceded by SGBs. Identifying and managing SGB may be beneficial and more likely to improve GERD.

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Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching

Keeratichananont

Patcharatrakul

Gonlachanvit

2023

J Neurogastroenterol Motil

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“…GERD has unknown causes, it is mostly caused by multifactorial pathogenesis like esophagogastric junction dysfunction, hypersensitivity of the esophagus, impaired esophageal bolus transit, and high intragastric pressure [4]. There are risk factors that increase the chance of getting GERD like age, obesity, lifestyle, taking non-steroidal anti-inflammatory drugs (NSAIDs), and smoking [5]. GERD is usually treated by proton pump inhibitors (PPIs) and lifestyle modification [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Recent epidemiological studies showed there was increasing GERD prevalence worldwide [3]. The worldwide [1,5]. Western countries and the USA have GERD prevalence higher than Asia, it ranges from 10 to 30% and more [9].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on a recent systematic review for GERD management, one of the most important management is lifestyle modification like decreasing weight, smoking cessation, and avoid heavy meals at night [ 4 ]. If GERD is left without treatment, it will lead to dangerous complications like Barrett’s esophagus then esophagus cancer [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent epidemiological studies showed there was increasing GERD prevalence worldwide [ 3 ]. The worldwide estimated prevalence of GERD ranged from 15 to 25%, Saudi Arabia reported 15-45.4%, western Asia reported 10-20%, the Middle East reported 8.7-33.1%, and eastern Asia reported less than 10% [ 1 , 5 ]. Western countries and the USA have GERD prevalence higher than Asia, it ranges from 10 to 30% and more [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Gastroesophageal Reflux Disease and Associated Risk Factors in the Eastern Region, Saudi Arabia

Ghadeer¹,

Alabbad²,

AlShaikh³

et al. 2021

Cureus

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Background Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disorder characterized by heartburn and acid regurgitation. A higher incidence is found in Arab countries. Untreated GERD has a negative impact on individuals that interfere with daily activities and impaired quality of life. This study aims to estimate the prevalence of GERD and associated risk factors in the Eastern region, Saudi Arabia. Material & Methodology A descriptive cross-sectional study was carried out among 1517 healthy participants from the Eastern province of Saudi Arabia from May to August 2021. The sample was randomly collected through a structured self-administered questionnaire. The questionnaire was composed of questions related to sociodemographic and lifestyle characteristics as risk factors for GERD. The existence of GERD was assessed by using GERD Questionnaire (GerdQ) for diagnosing GERD, when the score is 8 or more. Results A total of 1517 participants were included in the study: 58.8% male, 41.2% female; 9% of whom were pregnant. The age of participants ranged from 18 to 58 with a mean age of 27.5 ± 11.4 years old. The existence of GERD was 20.6% among the total participants, in which their GerdQ scores were 3-7 (68.9%), 8-10 (22.1%), and 8-11 (8.5%). The higher risk groups of having GERD were pregnant women, smoker, being male, regular usage of analgesia, soft drinks, and having a family history of GERD. Conclusion This study showed the prevalence of GERD among the general population of the Eastern region, Saudi Arabia was 20.6%. Several sociodemographic and lifestyle characteristics were associated with the disease. Further studies are needed to explore the role of psychological factors in developing GERD.

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Quality of life and severity of symptoms among patients with various degrees of reflux esophagitis: a prospective study

Mari,

Na’amnih,

Ghantous

et al. 2023

Sci Rep

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Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD symptoms using the Reflux disease questionnaire (RDQ) and QoL using the GERD QoL questionnaire. The patients were interviewed in their native language (Arabic or Hebrew). Overall, 149 (66.4% males) patients were included; 50 had EE grades C/D and 99 had grades A/B. The mean age at baseline and follow-up was 44.6 years (SD = 15.1) and 46.2 years (SD = 14.9), respectively. Cronbach’s alpha was 0.928 and 0.855 for the RDQ and QoL questionnaires, respectively. Patients with EE C/D grades had more severe symptoms than patients with EE A/B grades (P = 0.05), especially in regurgitation scores (P = 0.03). Females had more severe symptoms (overall) than males (adjusted OR = 2.34; 95% CI 1.12–4.90). Patients with the more severe esophagitis EE C/D group (adjusted OR = 1.98; 95% CI 0.93–4.24) and those who used PPIs treatment (adjusted OR = 2.19; 95% CI 0.95–5.01) reported more severe GERD symptoms. The number of schooling years was significantly associated with better QoL score (beta coefficient 1.33, P = 0.005) but not EE grade or GERD symptoms. Follow-up endoscopy conducted among 22 patients with EE grades C/D showed that 13 (59.1%) of these patients had normal endoscopic findings, 6 patients (27.3%) had a grade A EE, 1 patient (4.5%) had grade B, and 2 (9.1%) remained with grade C EE. The Arabic and Hebrew versions of the RDQ and QoL questionnaires were highly reliable. GERD symptoms severity was more profound among patients with more severe esophagitis. No significant association between EE grade and QoL; this negative result might be due to the improvement in esophagitis endoscopic findings among patients with C/D grade.

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The Determinants of the Quality of Life of Gastroesophageal Reflux Disease Patients Attending King Saud University Medical City

Cited by 12 publications

References 23 publications

Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching

Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching

Prevalence of Gastroesophageal Reflux Disease and Associated Risk Factors in the Eastern Region, Saudi Arabia

Quality of life and severity of symptoms among patients with various degrees of reflux esophagitis: a prospective study

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