The Determinants of Quality of Life of Nursing Home Residents with Young-Onset Dementia and the Differences between Dementia Subtypes

Appelhof, Britt; Bakker, Christian; IJssel, Jeannette C L van Duinen-van den; Zwijsen, Sandra A.; Smalbrugge, Martin; Verhey, Frans R.J.; Vugt, Marjolein E. de; Zuidema, Sytse U.; Koopmans, Raymond T.C.M.

doi:10.1159/000477087

Cited by 1,694 publications

(28 citation statements)

References 40 publications

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“…However, Appelhof et al [42] concluded that the relationships between the determinants and QoL are similar across dementia subtypes. Our sample seems to be more homogeneous than that in the study by Logsdon et al [9] with respect to cognitive status.…”

Section: Discussionmentioning

confidence: 99%

Psychometric Validation of the Czech Version of the Quality of Life – Alzheimer’s Disease Scale in Patients with Early-Stage Dementia

Kisvetrová

Školoudík

Herzig

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aims: The aim of this study was to perform a psychometric validation of the Czech version of the Quality of Life – Alzheimer’s Disease scale (QoL-AD) for patients with early-stage dementia. Methods: The sample included 212 patient-proxy pairs. For convergent validity, the Czech version of the Bristol Activities of Daily Living Scale (BADLS-CZ), the Short Physical Performance Battery (SPPB), and the Geriatric Depression Scale (GDS) were used. Results: The reliability of the QoL-AD for patients and caregivers was good (Cronbach’s α = 0.85, ICC = 0.25–0.54). A positive correlation existed between the QoL-AD and the SPPB, and negative correlations existed between the QoL-AD and the BADLS-CZ as well as between the QoL-AD and the GDS. Factor analysis resulted in a three-factor solution (physical and mental health, family life, and social security). Conclusion: The Czech version of the QoL-AD has good psychometric properties in compliance with international recommendations.

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Section: Discussionmentioning

confidence: 99%

Psychometric Validation of the Czech Version of the Quality of Life – Alzheimer’s Disease Scale in Patients with Early-Stage Dementia

Kisvetrová

Školoudík

Herzig

et al. 2018

Dement Geriatr Cogn Disord

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“…A Dutch study found a generally low prevalence of NPS in young-onset AD compared to late-onset AD during a 2-year follow-up [41]. In nursing home residents, Appelhof et al [42] found a significant association between NPS and psychotropic drug use and QOL. These findings suggest that the major predictors of QOL in YOD may be shared with people with LOD.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Hvidsten

Engedal

Selbæk

et al. 2018

Dement Geriatr Cogn Disord

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Aims: The aims of this study were to compare quality of life (QOL) in people with young-onset Alzheimer’s (AD) and frontotemporal (FTD) dementia, explore variables associated with QOL, and compare QOL in young-onset dementia (YOD) and late-onset dementia (LOD). Methods: Cross-sectional data from a Nordic multicenter study of 50 community-dwelling participants with AD and 38 with FTD were included. A comparison group consisted of 100 people with LOD. QOL was measured using self-reported Euro-QOL 5-Dimension and the proxy version of Quality of Life in Alzheimer’s Disease (QOL-AD) questionnaire. Neuropsychiatric symptoms and needs were assessed using the Cornell Scale for Depression in Dementia (CSDD), Neuropsychiatric Inventory (NPI), and Camberwell Assessment of Needs in the Elderly. Multiple linear regression and multilevel modeling was used to determine variables associated with QOL. Results: We found no differences between the two YOD groups in QOL. The variables associated with QOL were scores on the CSDD, NPI, and unmet needs. The proxy QOL-AD score in YOD was significantly higher compared to LOD (median 36.0 [IQR 10.0] vs. 33.0 [IQR 9.0]). Conclusion: The QOL in Nordic people with YOD was better compared to people with LOD. Our results show depressive symptoms to be associated with QOL irrespective of age and diagnosis.

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“…Earlier findings in this cohort showed no negative effect of antipsychotic drug use on the course of memory loss or dementia severity but it is suggested that psychotropic drug use in young-onset nursing home residents, causes a decrease in the quality of life (Appelhof et al, 2017;Gerritsen et al, 2018). However, studies about the (negative) effects of psychotropic drug use in people with young-onset dementia are scarce.…”

Section: Discussionmentioning

confidence: 65%

Psychotropic drug use in community-dwelling people with young-onset dementia: two-year course and determinants

Gerritsen¹,

Bakker²,

Bruls³

et al. 2019

Aging & Mental Health

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Objectives: The aim of this study was to describe the course of psychotropic drug use in people with young-onset dementia and to explore possible associations with age, sex, dementia severity, dementia subtype and neuropsychiatric symptoms. Methods: Psychotropic drug use was studied in 198 community-dwelling persons participating in the Needs in Young-onset Dementia study. Data about psychotropic drug use were retrieved at baseline, as well as at 6, 12, 18 and 24 months and was classified into five groups (antiepileptics, antipsychotics, anxiolytics, hypnotics/sedatives and antidepressants) and quantified as 'present' or 'absent'. Generalized Estimating Equation modeling and chi-square tests were used to study associations between the determinants and psychotropic drug use. Results: There was a statistically significant increase in the prevalence of psychotropic drug use from 52.3% to 62.6% during the course of the study. Almost three-quarters (72.4%) of the participants were treated with any psychotropic drug during the study, and more than one-third (37.4%) received psychotropic drugs continuously. Antipsychotics were used continuously in more than 10% of the participants and antidepressants in more than 25%. Increasing age was positively associated (p ¼ .018) with psychotropic drug use at baseline, while apathy symptoms were negatively associated (p ¼ .018). Conclusions: Despite the recommendations of various guidelines, the prolonged use of psychotropic drugs in community-dwelling people with young-onset dementia is high. Therefore, more attention is needed to timely evaluate psychotropic drug use and the introduction of self-management programs for caregivers should be encouraged to support caregivers in dealing with the neuropsychiatric symptoms caused by the dementia.

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The Determinants of Quality of Life of Nursing Home Residents with Young-Onset Dementia and the Differences between Dementia Subtypes

Cited by 1,694 publications

References 40 publications

Psychometric Validation of the Czech Version of the Quality of Life – Alzheimer’s Disease Scale in Patients with Early-Stage Dementia

Psychometric Validation of the Czech Version of the Quality of Life – Alzheimer’s Disease Scale in Patients with Early-Stage Dementia

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Psychotropic drug use in community-dwelling people with young-onset dementia: two-year course and determinants

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